Rastvorni nosač

Rastvorni nosači (SLC) su grupa membranskih transportnih proteina koja uključuje preko 400 članova, organiziranih u 66 porodica.^[1][2] Većina članova SLC grupe nalazi se u ćelijskoj membrani. Sistem genske nomenklature SLC izvorno je predložio HUGO-ov Odbor za gensku nomenklaturu (HGNC) i osnova je za službena HGNC imena gena koji kodiraju ove transportere. Općenitija klasifikacija transmembranskih transportera može se naći u TCDB bazi podataka.

Otopljene tvari koje transportiraju različiti članovi SLC grupe izuzetno su raznolike i uključuju napunjene i nenabijene organske molekule, kao i anorganske ione i transporter plina amonijaka.

Kao što je uobučajeno za integralni membranski protein, SLC sadrže niz hidrofobnih [transmembranskih alfa-heliksa međusobno povezanih hidrofilnim unutar- i vanćelijskim petljama. Ovisno o SLC, ovi transporteri su funkcionalni ili kao monomeri ili kao obvezni homo- ili heterooligomeri. Mnoge porodice SLC-a članovi su glavne natporodice olakšivača.

Opseg

Prema odgovarajućoj konvenciji sistema nomenklature, članovi unutar pojedine porodice SLC imaju međusobno više od 20-25% identitičnih sekvenci. Suprotno tome, homologija između porodica SLC je vrlo niska ili nikakva.^[3] Dakle, kriterij za uključivanje porodice u SLC grupu nije evolucijska povezanost s drugim porodicama SLC, već je funkcionalni (tj. Integralni membranski protein koji prenosi rastvorenu supstancu).

SLC grupa uključuje primjere transportnih proteina, kao štp su:

• Olakšani transporteri (omogućavaju otopljenim supstancama da teku nizvodno sa svojim elektrohemijskim gradijentima)
• sekundarni aktivni transporteri (dopuštaju rastvorima da teku uzvodno prema njihovom elektrokemijskom gradijentu, spajanjem za transport druge otopljene supstance koje teku nizvodno svojim gradijentom tako da je ukupna promjena slobodne energije i dalje povoljna)

Serija SLC ne uključuje članove porodica transportnih proteina koji su prethodno klasificirani u drugim široko prihvaćenim sistemima nomenklature, uključujući:

• primarni aktivni transporteri (omogućavaju protok uzbrdo prema elektrohemijskim gradijentima) kao što su ABC (ATP-vezna kaseta) transporteri spajanjem transporta do oslobađanja energije kao što je kao hidroliza ATP;
• ionski kanali
• akvaporini (vodeni kanali)

Subćelijska distribucija

Većina članova grupe SLC nalazi se u ćelijskoj membrani, ali neki nalaze se u mitohondrijama (najznačajnija je porodica SLC 25) ili u drugim unutarćelijskim organelama.

Sistem nomenklature

Imena pojedinačnih članova SLC-a imaju sljedeći format:

• SLCnXm

gdje je:

• SLC korijen od (SoLute Carrier);
• n = cijeli broj koji predstavlja porodicu (npr., 1-52);
• X = jedno slovo (A, B, C, ...) koje označava podporodicu;
• m = cijeli broj koji predstavlja pojedinačnog člana porodice (izoforma).

Naprimjer, SLC1A1 je prva izoforma potporodice A SLC-porodice 1.

Izuzetak je kod porodice SLC 21 (transporteri organskih aniona koji transportuju polipeptide), koji iz povijesnih razloga imaju imena u formatu SLCOnXm gdje je n = broj porodice, X = slovo potporodice i m = broj člana.

Iako HGNC samo dodjeljuje nomenklaturu ljudskim genima, ortolozi kičmenjaka tih gena usvajaju istu nomenklaturu (npr. ortolozi dodijeljeni VGNC-assigned orthologs of SLC10A1). Za glodare se simboli razlikuju od ostalih kičmenjaka, upotrebom naslova, tj. Slc1a1 koji označava glodarskog orthologa ljudskog gena SLC1A1.

Porodice

U SLC imenovane su sljedeće porodice:^[4]

1. Glutamat sa visokim afinitetom i neutralni aminokiselinski transporteri;^[5]
   • (SLC1A1, SLC1A2, SLC1A3, SLC1A4, SLC1A5, SLC1A6, SLC1A7)
2. olakšavajući GLUT transporter^[6]
   • (SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6, SLC2A7, SLC2A8, SLC2A9, SLC2A10, SLC2A11, SLC2A12, SLC2A13, SLC2A14)
3. teške podjedinice heterodimernih transportera aminokiselina^[7]
   • (SLC3A1, SLC3A2)
4. bikarbonatni transporter^[8]
   • (SLC4A1, SLC4A2, SLC4A3, SLC4A4, SLC4A5, SLC4A6, SLC4A7, SLC4A8, SLC4A9, SLC4A10, SLC4A11)
5. kotransporter natrij-glukoze^[9]
   • (SLC5A1, SLC5A2, SLC5A3, SLC5A4, SLC5A5, SLC5A6, SLC5A7, SLC5A8, SLC5A9, SLC5A10, SLC5A11, SLC5A12)
6. natrij- i hlorid-zavisni natrij: neurotransmiterski simporteri^[10]
   • (SLC6A1, SLC6A2, SLC6A3, SLC6A4, SLC6A5, SLC6A6, SLC6A7, SLC6A8, SLC6A9, SLC6A10, SLC6A11, SLC6A12, SLC6A13, SLC6A14, SLC6A15, SLC6A16, SLC6A17, SLC6A18, SLC6A19, SLC6A20)
7. kationski aminokiselinski transporter/povezan sa glikoproteinom^[11]
   • cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4)
   • glikoprotein-vezani/lahka ili katalitska podjedinica transporteri heterodimernih aminokiselina (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A10, SLC7A11, SLC7A13, SLC7A14)
8. izmjenjivači Na+/Ca2+^[12]
   • (SLC8A1, SLC8A2, SLC8A3)
9. izmjenjivač Na+/H+^[13]
   • (SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9A8, SLC9A9, SLC9A10, SLC9A11, SLC9B1, SLC9B2)
10. kotransporter natrijeve žučne soli^[14]
    • (SLC10A1, SLC10A2, SLC10A3, SLC10A4, SLC10A5, SLC10A6, SLC10A7)
11. protonski spregnuti metalni ionski transporter^[15]
    • (SLC11A1, SLC11A2)
12. kotransporter elektroneutralnog kationa-Cl^[16]
    • (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9)
13. Kotransporter Na+-sulfat/karboksilata^[17]
    • (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5)
14. urea transporter^[18]
    • (SLC14A1, SLC14A2)
15. protonski oligopeptidni kotransporter^[19]
    • (SLC15A1, SLC15A2, SLC15A3, SLC15A4)
16. monokarboksilatni transporter^[20]
    • (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14)
17. vezikulski glutamatni transporter^[21]
    • (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9)
18. vezikulski aminski transporter^[22]
    • (SLC18A1, SLC18A2, SLC18A3)
19. folate/thiamine transporter^[23]
    • (SLC19A1, SLC19A2, SLC19A3)
20. kotransporter tipa III Na+-fosfata^[24]
    • (SLC20A1, SLC20A2)
21. organsko anionsko transportiranje^[25]
    • potporodica 1 (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1)
    • potporodica 2 (SLCO2A1, SLCO2B1)
    • potporodica 3 (SLCO3A1)
    • potporodica 4 (SLCO4A1, SLCO4C1)
    • potporodica 5 (SLCO5A1)
    • potporodica 6 (SLCO6A1)
22. organski kation / anion /blizni transporter^[26]
    • (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A18AS, SLC22A19, SLC22A20, SLC22A23, SLC22A24, SLC22A25, SLC22A31)
23. transporter Na+-zavisne askorbinske kiseline^[27]
    • (SLC23A1, SLC23A2, SLC23A3, SLC23A4)
24. izmjenjivač Na+/(Ca2+-K+)^[28]
    • (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6)
25. mitohondrijski nosač^[29]
    • (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, UCP1(SLC25A7), UCP2(SLC25A8), UCP3(SLC25A9), SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46), SLC25A47, SLC25A48, MTCH1(SLC25A49), MTCH2(SLC25A50), SLC25A51, SLC25A52, SLC25A53
26. višenamjenski izmjenjivač aniona^[30]
    • (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11)
27. proteini transporta masnih kiselina^[31]
    • (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6)
28. Na+-spregnuti nukleozidni transport^[32]
    • (SLC28A1, SLC28A2, SLC28A3)
29. olakšavajući nukleozidni transporter^[33]
    • (SLC29A1, SLC29A2, SLC29A3, SLC29A4)
30. transporter cinka^[34]
    • (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)
31. transporter bakra^[35]
    • (SLC31A1, SLC31A2)
32. vezikulski inhibitorni transporter aminokiseline^[36]
    • (SLC32A1)
33. transporter Acetil-CoA^[37]
    • (SLC33A1)
34. kotransportere tipa II Na+-fosfata^[38]
    • (SLC34A1, SLC34A2, SLC34A3)
35. nukleotidno-šečerni transporter^[39]
    • potporodica A (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5)
    • potporodica B (SLC35B1, SLC35B2, SLC35B3, SLC35B4)
    • potporodica C (SLC35C1, SLC35C2)
    • potporodica D (SLC35D1, SLC35D2, SLC35D3)
    • potporodica E (SLC35E1, SLC35E2A, SLC35E2B, SLC35E3, SLC35E4)
    • potporodica F (SLC35F1, SLC35F2, SLC35F3, SLC35F4, SLC35F5)
    • potporodica G (SLC35G1, SLC35G3, SLC35G4, SLC35G5, SLC35G6)
36. transporter proton-spregnute aminokiseline^[40]
    • (SLC36A1, SLC36A2, SLC36A3, SLC36A4)
37. izmjenjivač šećer-fosfat/fosfat^[41]
    • (SLC37A1, SLC37A2, SLC37A3, SLC37A4)
38. transporterski sistem A & N, natrij-spregnute aminokiseline^[42]
    • (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A7, SLC38A8, SLC38A9, SLC38A10, SLC38A11)
39. transporter metalnih iona^[43]
    • (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14)
40. transporter bazolateralnog gvožđa^[44]
    • (SLC40A1)
41. MgtE-liiki transporter magnezija
    • (SLC41A1, SLC41A2, SLC41A3)
42. transporter smonijaka^[45][46]
    • (RHAG(SLC42A1), RHBG(SLC42A2), RHCG(SLC42A3))
43. Na+-nezavisni, sistem-L sličan transporteru aminokiseline
    • (SLC43A1, SLC43A2, SLC43A3)
44. holinoliki transporter
    • (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5)
45. pretpostavljeni šećerni transporter
    • (SLC45A1, SLC45A2, SLC45A3, SLC45A4)
46. Folatni transporter
    • (SLC46A1, SLC46A2, SLC46A3)
47. multidrug and toxin extrusion
    • (SLC47A1, SLC47A2)
48. porodica hemskog transportera
    • (SLC48A1)
49. Hemski transporter
    • (FLVCR1(SLC49A1), FLVCR2(SLC49A2), SLC49A3, SLC49A4)
50. transporteri izlaza šećera porodice SWEET
    • (SLC50A1)
51. Transporteri steroid-izvedenih molekula
    • (SLC51A, SLC51B)
52. Riboflavinska transporterska porodica RFVT/SLC52
    • (SLC52A1, SLC52A2, SLC52A3)
53. fosfatni nosači
    • (XPR1(SLC53A1)
54. Mitohondrijski piruvatni nosači
    • (MPC1(SLC54A1), MPC2(SLC54A2), MPC1L(SLC54A3))
55. Mitochondrijski kation/proton izmjenjivači
    • (LETM1(SLC54A1), LETM2(SLC54A2), LETMD1(SLC54A3))
56. Siderofleksini
    • (SFXN1(SLC56A1), SFXN2(SLC56A2), SFXN3(SLC56A3), SFXN4(SLC56A4), SFXN5(SLC56A5))
57. porodica NiPA-likih transportera magnezija
    • (NIPA1(SLC57A1), NIPA2(SLC57A2), NIPAL1(SLC57A3), NIPAL2(SLC57A4), NIPAL3(SLC57A5), NIPAL4(SLC57A6))
58. porodica MagT-likikih transportera magnezija
    • (MAGT1(SLC58A1), TUSC3(SLC58A2))
59. porodica simportera natrij-zavisnog lizofosfatidilholina
    • (MFSD2A(SLC59A1), MFSD2B(SLC59A2))
60. transporteri glucoze
    • (MFSD4A(SLC60A1), MFSD4B(SLC60A2))
61. porodica molibdatnih transportea
    • (MFSD5(SLC61A1))
62. Pirofosfatni transporteri
    • (ANKH(SLC62A1))
63. Sfingozin-fosfatni transporteri
    • (SPNS1(SLC63A1), SPNS2(SLC63A2), SPNS3(SLC63A3))
64. Golgijevi Ca2+/H+ izmjenjivači
    • (TMEM165(SLC64A1))
65. NPC-tip holesterolskih transportera
    • (NPC1(SLC65A1), NPC1L1(SLC65A2))
66. Kationaki aminokiselinski eksporteri
    • (SLC66A1, SLC66A2, SLC66A3, CTNS(SLC66A4), MPDU(SLC66A5))

Pretpostavljeni SLC

Pretpostavljeni SLC, koji se nazivaju i atipski SLC, novi su, vjerovatno vjerodostojni sekundarno aktivni ili olakšavajući proteini-transporteri koji dijele porijeklo predaka sa poznatim SLC-ima.^[2][47] Ovi SLC-ovi tipa MFS mogu se, međutim, podijeliti na 15 porodica olakšavajućih MFS iransportera (AMTF).^[47]

Svi pretpostavljeni SLC su prihvatljivi SLC-transporteri. Neki su samo "netipski" kada je u pitanju njihova nomenklatura; geni imaju SLC oznaku, ali kao zamjensko ime, i zadržali su svoj ranije dodijeljeni simbol gena "ne-SLC" kao odobreni simbol.

Evo nekoliko navedenih pretpostavljenih SLC-a: OCA2, CLN3, TMEM104, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1,^[48] MFSD2A, MFSD2B, MFSD3,^[48] MFSD4A,^[49] MFSD4B, MFSD5,^[50] MFSD6, MFSD6L, MFSD8, MFSD9,^[49] MFSD10, MFSD11,^[50] MFSD12, MFSD13A, MFSD14A,^[51] MFSD14B,^[51] UNC93A^[52][53] and UNC93B1.

Reference

1. Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA (februar 2004). "The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction". Pflügers Archiv. 447 (5): 465–8. doi:10.1007/s00424-003-1192-y. PMID 14624363.
2. Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
3. Höglund PJ, Nordström KJ, Schiöth HB, Fredriksson R (april 2011). "The solute carrier families have a remarkably long evolutionary history with the majority of the human families present before divergence of Bilaterian species". Molecular Biology and Evolution. 28 (4): 1531–41. doi:10.1093/molbev/msq350. PMC 3058773. PMID 21186191.
4. "SLCtables". slc.bioparadigms.org. Pristupljeno 7. 3. 2018.
5. Kanai Y, Hediger MA (februar 2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflügers Archiv. 447 (5): 469–79. doi:10.1007/s00424-003-1146-4. PMID 14530974.
6. Uldry M, Thorens B (februar 2004). "The SLC2 family of facilitated hexose and polyol transporters" (PDF). Pflügers Archiv. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891.
7. Palacín M, Kanai Y (februar 2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflügers Archiv. 447 (5): 490–4. doi:10.1007/s00424-003-1062-7. PMID 14770309.
8. Romero MF, Fulton CM, Boron WF (februar 2004). "The SLC4 family of HCO 3 - transporters". Pflügers Archiv. 447 (5): 495–509. doi:10.1007/s00424-003-1180-2. PMID 14722772.
9. Wright EM, Turk E (februar 2004). "The sodium/glucose cotransport family SLC5". Pflügers Archiv. 447 (5): 510–8. doi:10.1007/s00424-003-1063-6. PMID 12748858.
10. Chen NH, Reith ME, Quick MW (februar 2004). "Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6". Pflügers Archiv. 447 (5): 519–31. doi:10.1007/s00424-003-1064-5. PMID 12719981.
11. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (februar 2004). "CATs and HATs: the SLC7 family of amino acid transporters" (PDF). Pflügers Archiv. 447 (5): 532–42. doi:10.1007/s00424-003-1086-z. PMID 14770310.
12. Quednau BD, Nicoll DA, Philipson KD (februar 2004). "The sodium/calcium exchanger family-SLC8". Pflügers Archiv. 447 (5): 543–8. doi:10.1007/s00424-003-1065-4. PMID 12734757.
13. Orlowski J, Grinstein S (februar 2004). "Diversity of the mammalian sodium/proton exchanger SLC9 gene family". Pflügers Archiv. 447 (5): 549–65. doi:10.1007/s00424-003-1110-3. PMID 12845533.
14. Hagenbuch B, Dawson P (februar 2004). "The sodium bile salt cotransport family SLC10" (PDF). Pflügers Archiv. 447 (5): 566–70. doi:10.1007/s00424-003-1130-z. PMID 12851823.
15. Mackenzie B, Hediger MA (februar 2004). "SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1". Pflügers Archiv. 447 (5): 571–9. doi:10.1007/s00424-003-1141-9. PMID 14530973.
16. Hebert SC, Mount DB, Gamba G (februar 2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family". Pflügers Archiv. 447 (5): 580–93. doi:10.1007/s00424-003-1066-3. PMID 12739168.
17. Markovich D, Murer H (februar 2004). "The SLC13 gene family of sodium sulphate/carboxylate cotransporters". Pflügers Archiv. 447 (5): 594–602. doi:10.1007/s00424-003-1128-6. PMID 12915942.
18. Shayakul C, Hediger MA (februar 2004). "The SLC14 gene family of urea transporters". Pflügers Archiv. 447 (5): 603–9. doi:10.1007/s00424-003-1124-x. PMID 12856182.
19. Daniel H, Kottra G (februar 2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflügers Archiv. 447 (5): 610–8. doi:10.1007/s00424-003-1101-4. PMID 12905028.
20. Halestrap AP, Meredith D (februar 2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Archiv. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.
21. Reimer RJ, Edwards RH (februar 2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflügers Archiv. 447 (5): 629–35. doi:10.1007/s00424-003-1087-y. PMID 12811560.
22. Eiden LE, Schäfer MK, Weihe E, Schütz B (februar 2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflügers Archiv. 447 (5): 636–40. doi:10.1007/s00424-003-1100-5. PMID 12827358.
23. Ganapathy V, Smith SB, Prasad PD (februar 2004). "SLC19: the folate/thiamine transporter family". Pflügers Archiv. 447 (5): 641–6. doi:10.1007/s00424-003-1068-1. PMID 14770311.
24. Collins JF, Bai L, Ghishan FK (februar 2004). "The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors". Pflügers Archiv. 447 (5): 647–52. doi:10.1007/s00424-003-1088-x. PMID 12759754.
25. Hagenbuch B, Meier PJ (februar 2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties" (PDF). Pflügers Archiv. 447 (5): 653–65. doi:10.1007/s00424-003-1168-y. PMID 14579113.
26. Koepsell H, Endou H (februar 2004). "The SLC22 drug transporter family". Pflügers Archiv. 447 (5): 666–76. doi:10.1007/s00424-003-1089-9. PMID 12883891.
27. Takanaga H, Mackenzie B, Hediger MA (februar 2004). "Sodium-dependent ascorbic acid transporter family SLC23". Pflügers Archiv. 447 (5): 677–82. doi:10.1007/s00424-003-1104-1. PMID 12845532.
28. Schnetkamp PP (februar 2004). "The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond". Pflügers Archiv. 447 (5): 683–8. doi:10.1007/s00424-003-1069-0. PMID 14770312.
29. Palmieri F (februar 2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflügers Archiv. 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
30. Mount DB, Romero MF (februar 2004). "The SLC26 gene family of multifunctional anion exchangers". Pflügers Archiv. 447 (5): 710–21. doi:10.1007/s00424-003-1090-3. PMID 12759755.
31. Stahl A (februar 2004). "A current review of fatty acid transport proteins (SLC27)". Pflügers Archiv. 447 (5): 722–7. doi:10.1007/s00424-003-1106-z. PMID 12856180.
32. Gray JH, Owen RP, Giacomini KM (februar 2004). "The concentrative nucleoside transporter family, SLC28". Pflügers Archiv. 447 (5): 728–34. doi:10.1007/s00424-003-1107-y. PMID 12856181.
33. Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (februar 2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Archiv. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422.
34. Palmiter RD, Huang L (februar 2004). "Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers". Pflügers Archiv. 447 (5): 744–51. doi:10.1007/s00424-003-1070-7. PMID 12748859.
35. Petris MJ (februar 2004). "The SLC31 (Ctr) copper transporter family". Pflügers Archiv. 447 (5): 752–5. doi:10.1007/s00424-003-1092-1. PMID 12827356.
36. Gasnier B (februar 2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflügers Archiv. 447 (5): 756–9. doi:10.1007/s00424-003-1091-2. PMID 12750892.
37. Hirabayashi Y, Kanamori A, Nomura KH, Nomura K (februar 2004). "The acetyl-CoA transporter family SLC33". Pflügers Archiv. 447 (5): 760–2. doi:10.1007/s00424-003-1071-6. PMID 12739170.
38. Murer H, Forster I, Biber J (februar 2004). "The sodium phosphate cotransporter family SLC34" (PDF). Pflügers Archiv. 447 (5): 763–7. doi:10.1007/s00424-003-1072-5. PMID 12750889.
39. Ishida N, Kawakita M (februar 2004). "Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)". Pflügers Archiv. 447 (5): 768–75. doi:10.1007/s00424-003-1093-0. PMID 12759756.
40. Boll M, Daniel H, Gasnier B (februar 2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis". Pflügers Archiv. 447 (5): 776–9. doi:10.1007/s00424-003-1073-4. PMID 12748860.
41. Bartoloni L, Antonarakis SE (februar 2004). "The human sugar-phosphate/phosphate exchanger family SLC37". Pflügers Archiv. 447 (5): 780–3. doi:10.1007/s00424-003-1105-0. PMID 12811562.
42. Mackenzie B, Erickson JD (februar 2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflügers Archiv. 447 (5): 784–95. doi:10.1007/s00424-003-1117-9. PMID 12845534.
43. Eide DJ (februar 2004). "The SLC39 family of metal ion transporters". Pflügers Archiv. 447 (5): 796–800. doi:10.1007/s00424-003-1074-3. PMID 12748861.
44. McKie AT, Barlow DJ (februar 2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflügers Archiv. 447 (5): 801–6. doi:10.1007/s00424-003-1102-3. PMID 12836025.
45. Nakhoul NL, Hamm LL (februar 2004). "Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters". Pflügers Archiv. 447 (5): 807–12. doi:10.1007/s00424-003-1142-8. PMID 12920597.
46. Boron WF (decembar 2010). "Sharpey-Schafer lecture: gas channels". Experimental Physiology. 95 (12): 1107–30. doi:10.1113/expphysiol.2010.055244. PMC 3003898. PMID 20851859.
47. Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel putative solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
48. Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (februar 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
49. Perland E, Hellsten SV, Schweizer N, Arapi V, Rezayee F, Bushra M, Fredriksson R (2017). "Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice". PLOS ONE. 12 (10): e0186325. Bibcode:2017PLoSO..1286325P. doi:10.1371/journal.pone.0186325. PMC 5648162. PMID 29049335.
50. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
51. Lekholm E, Perland E, Eriksson MM, Hellsten SV, Lindberg FA, Rostami J, Fredriksson R (2017). "Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability". Frontiers in Molecular Neuroscience. 10: 11. doi:10.3389/fnmol.2017.00011. PMC 5263138. PMID 28179877.
52. Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)
53. Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology (jezik: English). 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.CS1 održavanje: nepoznati jezik (link)

SLC Tables. SLCtables

Vanjski linkovi

• Outline of families
• Datasets and Reagents on the Solute Carrier Family
• List of proteins at HGNC website