SLC9B2

Član 2 potporodice B porodice rastvornih nosača 9 (NHA2, katioski protonski antiporter 2), jest protein koji je kod ljudi kodiran genom SLC9B2 sa hromosoma 4.^[5]

SLC9B2
Identifikatori
Aliasi	SLC9B2
Vanjski ID-jevi	OMIM: 611789 MGI: 2140077 HomoloGene: 45381 GeneCards: SLC9B2
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4q24 Početak 103,019,868 bp[1] Kraj 103,085,829 bp[1]
Lokacija gena (miš) Hrom. Hromosom 3 (miš)[2] Bend 3|3 G3 Početak 135,013,461 bp[2] Kraj 135,051,148 bp[2]
Ontologija gena Molekularna funkcija • solute:proton antiporter activity • antiporter activity • monovalent cation:proton antiporter activity • lithium:proton antiporter activity • sodium:proton antiporter activity • vezivanje identičnih proteina Ćelijska komponenta • integral component of membrane • membrana • mitohondrija • mitochondrial inner membrane • endosome membrane • basolateral plasma membrane • synaptic vesicle membrane • sperm principal piece • ćelijska membrana • mitochondrial membranes • intracellular vesicle • endozom • apical plasma membrane • međućelijske veze • GO:0016023 citoplazmatska vezikula • projekcija ćelije • sinapsa • Treplja • motile cilium Biološki proces • proton transmembrane transport • ion transmembrane transport • cation transport • ion transport • positive regulation of osteoclast development • transmembrane transport • flagellated sperm motility • sodium ion transmembrane transport • regulation of insulin secretion involved in cellular response to glucose stimulus • clathrin-dependent endocytosis • sodium ion transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	133308	97086
Ensembl	ENSG00000164038	ENSMUSG00000037994
UniProt	Q86UD5	Q5BKR2
RefSeq (mRNK)	NM_001300754 NM_001300756 NM_178833	NM_178877
RefSeq (bjelančevina)	NP_001287683 NP_001287685 NP_849155 NP_001357128 NP_001357129 NP_001357130 NP_001357131 NP_001357132 NP_001357133 NP_001357134 NP_001357135 NP_001357136	NP_849208
Lokacija (UCSC)	Chr 4: 103.02 – 103.09 Mb	Chr 3: 135.01 – 135.05 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 537 aminokiselina, а molekulska težina 57.564 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MGDEDKRITY		EDSEPSTGMN		YTPSMHQEAQ		EETVMKLKGI		DANEPTEGSI
LLKSSEKKLQ		ETPTEANHVQ		RLRQMLACPP		HGLLDRVITN		VTIIVLLWAV
VWSITGSECL		PGGNLFGIII		LFYCAIIGGK		LLGLIKLPTL		PPLPSLLGML
LAGFLIRNIP		VINDNVQIKH		KWSSSLRSIA		LSIILVRAGL		GLDSKALKKL
KGVCVRLSMG		PCIVEACTSA		LLAHYLLGLP		WQWGFILGFV		LGAVSPAVVV
PSMLLLQGGG		YGVEKGVPTL		LMAAGSFDDI		LAITGFNTCL		GIAFSTGSTV
FNVLRGVLEV		VIGVATGSVL		GFFIQYFPSR		DQDKLVCKRT		FLVLGLSVLA
VFSSVHFGFP		GSGGLCTLVM		AFLAGMGWTS		EKAEVEKIIA		VAWDIFQPLL
FGLIGAEVSI		ASLRPETVGL		CVATVGIAVL		IRILTTFLMV		CFAGFNLKEK
IFISFAWLPK		ATVQAAIGSV		ALDTARSHGE		KQLEDYGMDV		LTVAFLSILI
TAPIGSLLIG		LLGPRLLQKV		EHQNKDEEVQ		GETSVQV

Funkcija

Natrij-vodikovi antiporteri, kao što je NHEDC2, pretvaraju protonsku pokretačku silu koju uspostavlja respiratorni lanac ili mitohondrijska F1F0 ATPaza u gradijente natrija koji pokreću druge procese. Oni zahtijevaju energiju, pretvaraju signale okoline u ćelijske odgovore ili funkciju u efluksu lijeka.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000164038 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037994 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2".
6. "UniProt, Q86UD5" (jezik: engleski). Pristupljeno 30. 10. 2017.
7. Xiang M, Feng M, Muend S, Rao R (novembar 2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. Bibcode:2007PNAS..10418677X. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.

Dopunska literatura

• Kondapalli KC, Kallay LM, Muszelik M, Rao R (oktobar 2012). "Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient". The Journal of Biological Chemistry. 287 (43): 36239–50. doi:10.1074/jbc.M112.403550. PMC 3476291. PMID 22948142.
• Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK (juli 2008). "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics. 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791. S2CID 5494045.
• Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA (decembar 2010). "Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - General Subjects. 1800 (12): 1241–7. doi:10.1016/j.bbagen.2010.08.001. PMC 2967667. PMID 20713131.
• Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW (august 2008). "Characterization of the sodium/hydrogen exchanger NHA2". Journal of the American Society of Nephrology. 19 (8): 1547–56. doi:10.1681/ASN.2007111245. PMC 2488271. PMID 18508966.
• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (juni 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P (januar 2008). "NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts". Bone. 42 (1): 180–92. doi:10.1016/j.bone.2007.09.046. PMC 3593247. PMID 17988971.
• Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N (mart 2010). "Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension". Journal of Molecular Biology. 396 (5): 1181–96. doi:10.1016/j.jmb.2009.12.055. PMC 2824056. PMID 20053353.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.