Klomipramin

ime
	3-(3-hloro-10,11-dihidro-5-dibenzo[]azepin-5-il)--dimetilpropan-1-amin
Klinički podaci
Prodajno ime	Anafranil
	Monografija
Kategorija trudnoće	C (U.S.);
Način primene	Oralno, IM, IV
Pravni status
Pravni status	℞ (Prescription only);
Farmakokinetički podaci
Bioraspoloživost	Oralno ~50%
Metabolizam	Hepatički
Poluvreme eliminacije	Klomipramin ~35 sata ; Desmetilklomipramin (glavni aktivni metabolit) ~50 sata
Izlučivanje	Renalno
Identifikatori
	303-49-1
kod	()
	2801
	2699
	:47780
	415
Hemijski podaci
Formula	19232
Molarna masa	314,9
	; ;
	; ;

Klomipramin (Anafranil) je triciklični antidepresiv (TCA). On je razvijen tokom 1960-tih i od tog vremena je u kliničkoj upotrebi širom sveta.^[2]^[3]^[4]^[5]

Кратке чињенице ime, Klinički podaci ...

Затвори

Klomipramin je blokator sledećih transportera:^[6]

Serotoninski transporter (SERT) ()
Norepinefrinski transporter (NET) ()
Dopaminski transporter (DAT) ()
Glicinski transporter ()

On je antagonist/inverzni agonist sledećih receptora:^[6]^[7]^[8]^[9]

Aktivni metabolit klomipramina, desmetilklomipramin ispoljava sledeći afinitet:

Norepinefrinski transporter (NET) ()^[10]

Triciklični antidepresivi

[1]
[2]
[3]
-{Healy, D. (2004). Let them eat Prozac: The unhealthy relationship between the pharmaceutical industry and depression. New York: New York University Press, p. 23.
[4]
Beaumont, G., & Healy, D. (1993). The place of clomipramine in the development of psychopharmacology. Journal of Psychopharmacology, 7, 383–393.}-
[5]
[6]
Millan, M. J.; Gobert, A.; F, Lejeune; . (2001). „S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine”. The Journal of Pharmacology and Experimental Therapeutics. 298 (2): 565—80. PMID 11454918.
[7]
Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993). „Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs”. Molecular Pharmacology. 43 (3): 320—7. PMID 7680751.
[8]
Ruat, M.; E, Traiffort; Leurs, R.; . (1993). „Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation”. Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8547—51. PMC 47394 . PMID 8397408. doi:10.1073/pnas.90.18.8547.
[9]
Toll, L.; Berzetei-Gurske IP; Polgar, W. E.; . (1998). „Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications”. NIDA Research Monograph. 178: 440—66. PMID 9686407.
[10]
P K Gillman (2007). „Tricyclic antidepressant pharmacology and therapeutic drug interactions updated”. Br J Pharmacol. 151 (6): 737—748. PMC 2014120 . PMID 17471183. doi:10.1038/sj.bjp.0707253.

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] [1]

[2] [2]

[3] [3]
-{Healy, D. (2004). Let them eat Prozac: The unhealthy relationship between the pharmaceutical industry and depression. New York: New York University Press, p. 23.

[4] [4]
Beaumont, G., & Healy, D. (1993). The place of clomipramine in the development of psychopharmacology. Journal of Psychopharmacology, 7, 383–393.}-

[5] [5]

[pmid11454918-6] [6]
Millan, M. J.; Gobert, A.; F, Lejeune; . (2001). „S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine”. The Journal of Pharmacology and Experimental Therapeutics. 298 (2): 565—80. PMID 11454918.

[pmid7680751-7] [7]
Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (1993). „Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs”. Molecular Pharmacology. 43 (3): 320—7. PMID 7680751.

[pmid8397408-8] [8]
Ruat, M.; E, Traiffort; Leurs, R.; . (1993). „Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation”. Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8547—51. PMC 47394 . PMID 8397408. doi:10.1073/pnas.90.18.8547.

[pmid9686407-9] [9]
Toll, L.; Berzetei-Gurske IP; Polgar, W. E.; . (1998). „Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications”. NIDA Research Monograph. 178: 440—66. PMID 9686407.

[pmid17471183-10] [10]
P K Gillman (2007). „Tricyclic antidepressant pharmacology and therapeutic drug interactions updated”. Br J Pharmacol. 151 (6): 737—748. PMC 2014120 . PMID 17471183. doi:10.1038/sj.bjp.0707253.

[2]

[3]

[4]

[5]

[1]

[6]

[7]

[8]

[9]

[10]

Klomipramin

Farmakologija

Vidi još

Reference