H1 receptor je histaminski receptor iz familije rodopsinu sličnih G protein spregnutih receptora. Ovaj receptor, koji aktivira biogeni amin histamin, je izražen širom tela, u glatkim mišićima, vaskularnim endotelnim ćelijama, u srcu, i u centralnom nervnom sistemu. H1 receptor je spregnut sa intracelularnim G proteinom () koji aktivira signalni put fosfolipaze C i fosfatidilinozitola (PIP2). Antihistamini koji deluju na ovaj receptor se koriste kao lekovi protiv alergije. Kristalna struktura receptora je određena.[1]
Кратке чињенице Histamine receptor H1, Dostupne strukture ...
Затвори
Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata (2011). „Structure of the human histamine H1 receptor complex with doxepin”. Nature. 475 (7354): 65—70. PMID 21697825. doi:10.1038/nature10236.
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