UNC93A

Homolog A Unc-93 (C. elegans) jest protein koji je kod ljudi kodiran genom UNC93A.^[5]

UNC93A
Identifikatori
Aliasi	UNC93A
Vanjski ID-jevi	OMIM: 607995 MGI: 1933250 HomoloGene: 10356 GeneCards: UNC93A
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek)[1] Bend 6q27 Početak 167,271,169 bp[1] Kraj 167,316,014 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17 A1|17 8.78 cM Početak 13,327,504 bp[2] Kraj 13,350,697 bp[2]
Ontologija gena Molekularna funkcija • molekularna funkcija Ćelijska komponenta • membrana • integral component of membrane • ćelijska membrana Biološki proces • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	54346	381058
Ensembl	ENSG00000112494	ENSMUSG00000067049
UniProt	Q86WB7	Q710D3
RefSeq (mRNK)	NM_001143947 NM_018974	NM_199252
RefSeq (bjelančevina)	NP_001137419 NP_061847	NP_954860
Lokacija (UCSC)	Chr 6: 167.27 – 167.32 Mb	Chr 17: 13.33 – 13.35 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 457 aminokiselina, а molekulska težina 50.270 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDRSLRNVLV		VSFGFLLLFT		AYGGLQSLQS		SLYSEEGLGV		TALSTLYGGM
LLSSMFLPPL		LIERLGCKGT		IILSMCGYVA		FSVGNFFASW		YTLIPTSILL
GLGAAPLWSA		QCTYLTITGN		THAEKAGKRG		KDMVNQYFGI		FFLIFQSSGV
WGNLISSLVF		GQTPSQETLP		EEQLTSCGAS		DCLMATTTTN		STQRPSQQLV
YTLLGIYTGS		GVLAVLMIAA		FLQPIRDVQR		ESEGEKKSVP		FWSTLLSTFK
LYRDKRLCLL		ILLPLYSGLQ		QGFLSSEYTR		SYVTCTLGIQ		FVGYVMICFS
ATDALCSVLY		GKVSQYTGRA		VLYVLGAVTH		VSCMIALLLW		RPRADHLAVF
FVFSGLWGVA		DAVWQTQNNA		LYGVLFEKSK		EAAFANYRLW		EALGFVIAFG
YSMFLCVHVK		LYILLGVLSL		TMVAYGLVEC		VESKNPIRPH		APGQVNQAED
EEIQTKM

Funkcija

Kod ljudi, Unc93A je glavna poroduca facilitatora (MFS) i navodna porodica rastvornih nosača.^[7][8] Pripada atipskim SL-ovima koji su nedavno opisani.^[7] Stoga se pretpostavlja da je UNC93A proteinski transporter.

Blisko je srodan sa UNC93B1 i MFSD11.^[9][10]

Na UNC93A utiče nedostatak aminokiselina u kulturama korteknih ćelija^[8][9] i u izgladnjivanju u uvjetima in vivo.^[9]

Eksprimira se u neuronima, sa bojenjem blizu plazmamembrane.^[9]

Reference

1. GRCh38: Ensembl release 89: ENSG00000112494 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067049 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Unc-93 homolog A (C. elegans)".
6. "UniProt, Q86WB7" (jezik: engleski). Pristupljeno 11. 10. 2021.
7. Perland E, Fredriksson R (mart 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
8. Perland E, Bagchi S, Klaesson A, Fredriksson R (septembar 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
9. Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience (jezik: English). 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.CS1 održavanje: nepoznati jezik (link)
10. Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

Dopunska literatura

• ^[1][2] for functional studies in C.elegans.*^[3]
• Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (oktobar 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.

1. Levin JZ, Horvitz HR (april 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
2. de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (oktobar 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
3. Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology (jezik: English). 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.CS1 održavanje: nepoznati jezik (link)