STT3B

Podjedinica STT3B dolihil-difosfooligosaharid-protein glikoziltransferaze jest enzim koji je kod ljudi kodiran genom STT3B sa hromosoma 3.^[5][6][7]

STT3B
Identifikatori
Aliasi	STT3B
Vanjski ID-jevi	OMIM: 608605 MGI: 1915542 HomoloGene: 7387 GeneCards: STT3B
Lokacija gena (čovjek) Hrom. Hromosom 3 (čovjek)[1] Bend 3p23 Početak 31,532,638 bp[1] Kraj 31,637,616 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 F3 Početak 115,071,649 bp[2] Kraj 115,139,489 bp[2]
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • oligosaccharyl transferase activity • dolichyl-diphosphooligosaccharide-protein glycotransferase activity • glycosyltransferase activity • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • integral component of membrane • oligosaccharyltransferase complex • Endoplazmatski retikulum • membrana • endoplasmic reticulum membrane • GO:0009327 makromolekulani kompleks • oligosaccharyltransferase I complex Biološki proces • Posttranslacione modifikacije • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • co-translational protein modification • response to unfolded protein • protein N-linked glycosylation via asparagine • ubiquitin-dependent ERAD pathway • glycoprotein catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	201595	68292
Ensembl	ENSG00000163527	ENSMUSG00000032437
UniProt	Q8TCJ2	Q3TDQ1
RefSeq (mRNK)	NM_178862	NM_024222
RefSeq (bjelančevina)	NP_849193	NP_077184
Lokacija (UCSC)	Chr 3: 31.53 – 31.64 Mb	Chr 9: 115.07 – 115.14 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 826 aminokiselina, а molekulska težina 93.674 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAEPSAPESK		HKSSLNSSPW		SGLMALGNSR		HGHHGPGAQC		AHKAAGGAAP
PKPAPAGLSG		GLSQPAGWQS		LLSFTILFLA		WLAGFSSRLF		AVIRFESIIH
EFDPWFNYRS		THHLASHGFY		EFLNWFDERA		WYPLGRIVGG		TVYPGLMITA
GLIHWILNTL		NITVHIRDVC		VFLAPTFSGL		TSISTFLLTR		ELWNQGAGLL
AACFIAIVPG		YISRSVAGSF		DNEGIAIFAL		QFTYYLWVKS		VKTGSVFWTM
CCCLSYFYMV		SAWGGYVFII		NLIPLHVFVL		LLMQRYSKRV		YIAYSTFYIV
GLILSMQIPF		VGFQPIRTSE		HMAAAGVFAL		LQAYAFLQYL		RDRLTKQEFQ
TLFFLGVSLA		AGAVFLSVIY		LTYTGYIAPW		SGRFYSLWDT		GYAKIHIPII
ASVSEHQPTT		WVSFFFDLHI		LVCTFPAGLW		FCIKNINDER		VFVALYAISA
VYFAGVMVRL		MLTLTPVVCM		LSAIAFSNVF		EHYLGDDMKR		ENPPVEDSSD
EDDKRNQGNL		YDKAGKVRKH		ATEQEKTEEG		LGPNIKSIVT		MLMLMLLMMF
AVHCTWVTSN		AYSSPSVVLA		SYNHDGTRNI		LDDFREAYFW		LRQNTDEHAR
VMSWWDYGYQ		IAGMANRTTL		VDNNTWNNSH		IALVGKAMSS		NETAAYKIMR
TLDVDYVLVI		FGGVIGYSGD		DINKFLWMVR		IAEGEHPKDI		RESDYFTPQG
EFRVDKAGSP		TLLNCLMYKM		SYYRFGEMQL		DFRTPPGFDR		TRNAEIGNKD
IKFKHLEEAF		TSEHWLVRIY		KVKAPDNRET		LDHKPRVTNI		FPKQKYLSKK
TTKRKRGYIK		NKLVFKKGKK		ISKKTV

Funkcija

STT3B protein sadrži visoko imunogeni epitop manjeg histokompatibilnog antigena od devet aminokiselina, B6(dom1). Poput ITM1 (MIM 601134), STT3B je homologan sa STT3 kvasca, oligosahariltransferaza neophodna za proliferaciju ćelija.^[7][9]

Također pogledajte

• Oligosaharid
• Transferaza

Reference

1. GRCh38: Ensembl release 89: ENSG00000163527 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032437 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (juli 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
6. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
7. "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
8. "UniProt, Q8TCJ2" (jezik: engleski). Pristupljeno 5. 11. 2021.
9. McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (novembar 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. Springer Science and Business Media LLC. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.

Dopunska literatura

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Shibatani T, David LL, McCormack AL, Frueh K, Skach WR (april 2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.

Vanjski linkovi