Perifilin-1 je protein koji je kod ljudi kodiran genom PPHLN1.[5]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Protein kodiran ovim genom jedan je od nekoliko proteina koji se sekventno ugrađuju u stvrdnutu čelijsku ovojnicu tokom terminalne diferencijacije keratinocita u vanjskim slojevima epiderme.
Ovaj protein stupa u interakciju sa periplakinom, koji je poznat kao prekursor omotača rožnatih ćelija. Obrazac ćelijske lokalizacije i nerastvorljivost ovog proteina sugeriraju da on može imati ulogu u diferencijaciji epitela i pridonijeti njegovom integritetu i formiranju barijere. Uočeno je više alternativno prerađenih varijanti transkripta koje kodiraju različite izoforme.[5]
Dužina polipeptidnog lanca je 458 aminokiselina, a molekulska težina 52.737 Da.[6]
10 | | 20 | | 30 | | 40 | | 50 |
MWSEGRYEYE | | RIPRERAPPR | | SHPSDGYNRL | | VNIVPKKPPL | | LDRPGEGSYN |
RYYSHVDYRD | | YDEGRSFSHD | | RRSGPPHRGD | | ESGYRWTRDD | | HSASRQPEYR |
DMRDGFRRKS | | FYSSHYARER | | SPYKRDNTFF | | RESPVGRKDS | | PHSRSGSSVS |
SRSYSPERSK | | SYSFHQSQHR | | KSVRPGASYK | | RQNEGNPERD | | KERPVQSLKT |
SRDTSPSSGS | | AVSSSKVLDK | | PSRLTEKELA | | EAASKWAAEK | | LEKSDESNLP |
EISEYEAGST | | APLFTDQPEE | | PESNTTHGIE | | LFEDSQLTTR | | SKAIASKTKE |
IEQVYRQDCE | | TFGMVVKMLI | | EKDPSLEKSI | | QFALRQNLHE | | IESAGQTWQQ |
VPPVRNTEMD | | HDGTPENEGE | | ETAQSAPQPP | | QAPQPLQPRK | | KRVRRTTQLR |
RTTGAPDITW | | GMLKKTTQEA | | ERILLRTQTP | | FTPENLFLAM | | LSVVHCNSRK |
DVKPENKQ |
- Simboli
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
- Kazerounian S, Uitto J, Aho S (2003). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. 11 (5): 428–38. doi:10.1034/j.1600-0625.2002.110506.x. PMID 12366696. S2CID 25735126.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kazerounian S, Aho S (2003). "Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope". J. Biol. Chem. 278 (38): 36707–17. doi:10.1074/jbc.M303896200. PMID 12853457.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Kurita M, Suzuki H, Masai H, et al. (2004). "Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest". Biochem. Biophys. Res. Commun. 324 (2): 554–61. doi:10.1016/j.bbrc.2004.09.083. PMID 15474462.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mizrachi-Koren M, Geiger D, Indelman M, et al. (2005). "Identification of a novel locus associated with congenital recessive ichthyosis on 12p11.2-q13". J. Invest. Dermatol. 125 (3): 456–62. doi:10.1111/j.0022-202X.2005.23777.x. PMID 16117785.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.