Homeoboksni protein NANOG je transkripcijski faktor koji pomaže embrionskim matičnim ćelijama (ESC) održavanje pluripotencije putem supresije faktora ćelijke determinacije.[5] Several types of cancer are associated with NANOG.
Kratke činjenice NANOG, Dostupne strukture ...
NANOG |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/0d/NANOG.png/250px-NANOG.png) |
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Identifikatori |
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Aliasi | NANOG |
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Vanjski ID-jevi | OMIM: 607937 MGI: 1919200 HomoloGene: 78027 GeneCards: NANOG |
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Ontologija gena |
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Molekularna funkcija | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Ćelijska komponenta | • Jedarce • Jedro • Nukleoplazma
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Biološki proces | • Regulacija ekspresije gena • regulation of cell differentiation • multicellular organism development • Ćelijska diferencijacija • Ćelijska proliferacija • GO:0009373 regulation of transcription, DNA-templated • somatic stem cell population maintenance • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • endodermal cell fate specification • negative regulation of nucleic acid-templated transcription • stem cell population maintenance • transcription by RNA polymerase II • cytokine-mediated signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of stem cell proliferation
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 12: 7.79 – 7.8 Mb | Chr 6: 122.68 – 122.69 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori