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CYP51A1
位於7號人類染色體的基因 / 维基百科,自由的 encyclopedia
细胞色素 P450 51A1(英语:Cytochrome P450 27A1,缩写CYP51A1)也被称为羊毛甾醇-14α-脱甲基酶(Lanosterol 14α-demethylase,EC 1.14.14.154),是细胞色素P450超家族的一员,在人类基因组中由CYP51A1基因编码,可催化带有14α甲基的甾醇(如羊毛甾醇)去甲基化并D环上的C14-C15脱氢生成对应的甾醇(如4,4-二甲基胆甾-8(9),14,24-三烯-3β-醇)[6]。在后鞭毛生物(包括动物和真菌)的胆固醇合成中,CYP51A1催化2,3-环氧鲨烯成环后的第一步反应,是参与甾体生成的第一个CYP酶[7]。
![](http://upload.wikimedia.org/wikipedia/commons/thumb/6/6a/Lanosterol_Demethylation_Pathway.png/640px-Lanosterol_Demethylation_Pathway.png)
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主条目:CYP51
Quick Facts CYP51A1, 已知的结构 ...
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Quick Facts Cytochrome P450, Family 51, Subfamily A, Polypeptide 1, 识别 ...
Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 | |
---|---|
识别 | |
符号 | CYP51A1 |
替换符号 | CYP51, P45014DM |
Entrez | 1595 |
HUGO | 2649 |
OMIM | 601637 |
RefSeq | NM_000786 |
UniProt | Q16850 |
其他数据 | |
EC编号 | 1.14.14.154 |
基因座 | 7 q21.2-21.3 |
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/16/Lanosterol_skeletal.svg/640px-Lanosterol_skeletal.svg.png)
CYP51A1所属的CYP51家族是进化上较保守的家族[8],在功能上都催化对应甾醇的14α脱甲基化[9],在真核域和细菌域中都广泛存在,但不同生物界之间CYP51的相似性只有22-30%[10]。
参考文献
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023). Human Metabolome Database. February 2014 [2020-04-18]. (原始内容存档于2017-12-26).
- Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochimica et Biophysica Acta. March 2007, 1770 (3): 467–77. PMC 2324071
. PMID 16963187. doi:10.1016/j.bbagen.2006.07.018.
- Lepesheva GI, Waterman MR. CYP51--the omnipotent P450. Molecular and Cellular Endocrinology. February 2004, 215 (1–2): 165–70. PMID 15026190. doi:10.1016/j.mce.2003.11.016.
- Becher R, Wirsel SG. Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens. Applied Microbiology and Biotechnology. August 2012, 95 (4): 825–40. PMID 22684327. doi:10.1007/s00253-012-4195-9.
- Lepesheva GI, Waterman MR. Structural basis for conservation in the CYP51 family. Biochimica et Biophysica Acta. January 2011, 1814 (1): 88–93. PMC 2962772
. PMID 20547249. doi:10.1016/j.bbapap.2010.06.006.