约在公元前155年之后，月氏再次被乌孙和匈奴联盟所击败，被迫再向南移动，而又再次驱散斯基泰人，后者向南迁移至巴克特里亚和今日的阿富汗，并向西南方向的帕提亚接近。公元前145年左右，塞迦人似乎已进入希腊-巴克特里亚王国的领土，他们在那里把希腊城市埃康农（英语：Alexandria on the Oxus）焚为为平地。（请参阅希腊-巴克特里亚王国#灭亡）月氏留在阿姆河北岸的粟特，但正如中国汉朝使者张骞在公元前126年访问该地区时所描述，他们成为巴克特里亚地区塞迦人的宗主国。[29]
印度-斯基泰人在印度被称为“Shaka”，是波斯人的Saka的扩展名。从《摩诃婆罗多》战争时期（大约在公元前3100年，在斗争时(印度教中四个宇迦循环中的最后一个)开始之前)[56]）发生时，Shakas在文本中被提及无数次，如往世书、摩奴法论、罗摩衍那、摩诃婆罗多、大疏（Mahabhasiya of Patanjali）、伐罗诃密希罗的Brhat Samhita、Kavyamimamsa、Brihat-Katha-Manjari、故事海，和其他一些古文本。它们被描述为西北部好战部落中的一支。
入侵印度并建立多个王国的斯基泰人部族，除塞迦人以外，还包括其他同盟部落，例如米底人、大益、和马萨革泰人。这些部族的人后来全部被印度主流社会的刹帝利社群所吸收。[63]
Shakas从前是居住在跨赫莫多斯（英语：Hemodos）地区的人们，即往世书中提到的Shakadvipa，或是古典著作中提到的Scythia。查拉克斯的伊西多（英语：Isidor of Charax）（公元1世纪初）中、证明这些人居住在Sakastana（现代锡斯坦）。爱利脱利亚海周航记（约公元70-80年）也证明居住在印度河下游的明纳加拉是斯基泰人。托勒密（约公元140年）还证明居住在印度西南部，包括帕塔林（英语：Patalene）和索拉什特拉地区的是印度-斯基泰人。
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