PPP4C

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.^[5][6]

PPP4C
Identifiers
Aliases	PPP4C, PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 catalytic subunit
External IDs	OMIM: 602035; MGI: 1891763; HomoloGene: 2038; GeneCards: PPP4C; OMA:PPP4C - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,075,978 bp[1] End 30,085,376 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,385,038 bp[2] End 126,391,668 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte stromal cell of endometrium mucosa of transverse colon right testis left testis skin of abdomen skin of leg ganglionic eminence left adrenal gland Top expressed in mandibular prominence maxillary prominence granulocyte epiblast somite abdominal wall primitive streak thymus ventricular zone medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding NF-kappaB-inducing kinase activity protein binding hydrolase activity protein serine/threonine phosphatase activity Cellular component plasma membrane nucleoplasm microtubule organizing center cytoskeleton nucleus protein phosphatase 4 complex cytoplasm cytosol Biological process regulation of double-strand break repair via homologous recombination NIK/NF-kappaB signaling protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5531 56420 Ensembl ENSG00000149923 ENSMUSG00000030697 UniProt P60510 P97470 RefSeq (mRNA) NM_001303503 NM_001303504 NM_001303506 NM_001303507 NM_002720 NM_019674 NM_001360464 RefSeq (protein) NP_001290432 NP_001290433 NP_001290435 NP_001290436 NP_002711 NP_062648 NP_001347393 Location (UCSC) Chr 16: 30.08 – 30.09 Mb Chr 7: 126.39 – 126.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP4C has been shown to interact with:

• CCDC6,^[7][8]
• CCT2,^[7][9]
• CCT3,^[7][9]
• CCT4,^[7][9]
• CCT5,^[7][9]
• CCT6A,^[7][9]
• CCT7,^[7][9]
• IGBP1,^[7][9][10]
• PPP2R1A,^[7][8]
• PPP4R1,^[7][8][9]
• REL,^[11]
• SMEK2,^[7][8][9]
• T-complex 1,^[7][9] and
• TRAF6.^[12]

References

1. GRCh38: Ensembl release 89: ENSG00000149923 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030697 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
6. "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
9. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
10. Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
11. Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
12. Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. S2CID 27700566.

Further reading

• Brewis ND, Cohen PT (Dec 1992). "Protein phosphatase X has been highly conserved during mammalian evolution". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171 (2): 231–3. doi:10.1016/0167-4781(92)90129-n. PMID 1336397.
• Brewis ND, Street AJ, Prescott AR, Cohen PT (Mar 1993). "PPX, a novel protein serine/threonine phosphatase localized to centrosomes". The EMBO Journal. 12 (3): 987–96. doi:10.1002/j.1460-2075.1993.tb05739.x. PMC 413299. PMID 8384557.
• Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE (Oct 1997). "Carboxymethylation of nuclear protein serine/threonine phosphatase X". The Biochemical Journal. 327 ( Pt 2) (Pt 2): 481–6. doi:10.1042/bj3270481. PMC 1218819. PMID 9359419.
• Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
• Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry. 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
• Hastie CJ, Carnegie GK, Morrice N, Cohen PT (May 2000). "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres". The Biochemical Journal. 347 Pt 3 (Pt 3): 845–55. doi:10.1042/0264-6021:3470845. PMC 1221024. PMID 10769191.
• Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL (Jun 2004). "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation". The Journal of Biological Chemistry. 279 (25): 26143–8. doi:10.1074/jbc.M402362200. PMID 15073167.
• Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (Nov 2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". The Journal of Biological Chemistry. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
• Zhou G, Boomer JS, Tan TH (Nov 2004). "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1". The Journal of Biological Chemistry. 279 (47): 49551–61. doi:10.1074/jbc.M410317200. PMID 15364934.
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.