PPP2R1A

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene.^[5] In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).^[6]

PPP2R1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W
Identifiers
Aliases	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
External IDs	OMIM: 605983; MGI: 1926334; HomoloGene: 68559; GeneCards: PPP2R1A; OMA:PPP2R1A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 52,190,048 bp[1] End 52,229,518 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.2 Start 21,165,573 bp[2] End 21,186,178 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart ganglionic eminence right frontal lobe right hemisphere of cerebellum ventricular zone right adrenal cortex prefrontal cortex cingulate gyrus right auricle left adrenal cortex Top expressed in vestibular membrane of cochlear duct motor neuron facial motor nucleus primitive streak endothelial cell of lymphatic vessel anterior horn of spinal cord vas deferens ciliary body medial ganglionic eminence hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding protein heterodimerization activity protein phosphatase regulator activity protein antigen binding Cellular component cytoplasm cytosol microtubule cytoskeleton protein phosphatase type 2A complex chromosome mitochondrion chromosome, centromeric region extracellular exosome nucleus plasma membrane membrane lateral plasma membrane dendrite cell projection synapse glutamatergic synapse Biological process apoptotic process regulation of meiotic cell cycle process involved in oocyte maturation meiotic sister chromatid cohesion, centromeric regulation of transcription, DNA-templated ceramide metabolic process regulation of DNA replication chromosome segregation protein dephosphorylation meiotic spindle elongation female meiotic nuclear division response to organic substance positive regulation of extrinsic apoptotic signaling pathway in absence of ligand peptidyl-serine dephosphorylation regulation of Wnt signaling pathway regulation of cell adhesion G2/M transition of mitotic cell cycle negative regulation of cell growth RNA splicing regulation of cell differentiation regulation of growth mitotic nuclear membrane reassembly mitotic sister chromatid separation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay second-messenger-mediated signaling ciliary basal body-plasma membrane docking negative regulation of tyrosine phosphorylation of STAT protein regulation of G2/M transition of mitotic cell cycle regulation of phosphoprotein phosphatase activity protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.^[7]

Interactions

PPP2R1A has been shown to interact with:

• CTTNBP2NL,^[8]
• FAM40A,^[8]
• PPP2CB,^[8][9] PPP2CA,^[8][9] PPP4C,^[10]
• PPP2R2A,^[8][9]
• PPP2R3B,^[8][9]
• PPP2R5A.^[8][9]
• STK24,^[8][11]
• STRN,^[8] and
• STRN3.^[8]

Arabidopsis RCN1

RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.