IGBP1

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.^[5][6]

IGBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IYP
Identifiers
Aliases	IGBP1, ALPHA-4, IBP1, immunoglobulin (CD79A) binding protein 1, immunoglobulin binding protein 1, alpha4, MRXS28
External IDs	OMIM: 300139; MGI: 1346500; HomoloGene: 44067; GeneCards: IGBP1; OMA:IGBP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,133,447 bp[1] End 70,166,324 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 99,537,897 bp[2] End 99,559,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left ovary tendon of biceps brachii ganglionic eminence gastrocnemius muscle glutes Achilles tendon parotid gland right ovary monocyte Top expressed in vas deferens left lung lobe seminal vesicula efferent ductule migratory enteric neural crest cell skin of external ear conjunctival fornix fossa lacrimal gland external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase 2A binding Cellular component cytoplasm cytosol Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to interleukin-1 regulation of microtubule-based movement negative regulation of transcription by RNA polymerase II response to tumor necrosis factor B cell activation regulation of signal transduction negative regulation of stress-activated MAPK cascade signal transduction regulation of dephosphorylation regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3476 18518 Ensembl ENSG00000089289 ENSMUSG00000031221 UniProt P78318 Q61249 RefSeq (mRNA) NM_001551 NM_001370192 NM_001370193 NM_001370194 NM_008784 RefSeq (protein) NP_001542 NP_001357121 NP_001357122 NP_001357123 NP_032810 Location (UCSC) Chr X: 70.13 – 70.17 Mb Chr X: 99.54 – 99.56 Mb PubMed search [3] [4]
Wikidata
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Function

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.^[6]

Interactions

IGBP1 has been shown to interact with PPP4C,^[7][8][9] PPP6C^[8][9] and PPP2CA.^{[8][9][10][11]}