IGBP1

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.^[5][6]

IGBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IYP
Identifiers
Aliases	IGBP1, ALPHA-4, IBP1, immunoglobulin (CD79A) binding protein 1, immunoglobulin binding protein 1, alpha4, MRXS28
External IDs	OMIM: 300139; MGI: 1346500; HomoloGene: 44067; GeneCards: IGBP1; OMA:IGBP1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 70,133,447 bp[1] End 70,166,324 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 99,537,897 bp[2] End 99,559,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left ovary tendon of biceps brachii ganglionic eminence gastrocnemius muscle glutes Achilles tendon parotid gland right ovary monocyte Top expressed in vas deferens left lung lobe seminal vesicula efferent ductule migratory enteric neural crest cell skin of external ear conjunctival fornix fossa lacrimal gland external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein phosphatase regulator activity protein phosphatase 2A binding Cellular component cytoplasm cytosol Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to interleukin-1 regulation of microtubule-based movement negative regulation of transcription by RNA polymerase II response to tumor necrosis factor B cell activation regulation of signal transduction negative regulation of stress-activated MAPK cascade signal transduction regulation of dephosphorylation regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3476 18518 Ensembl ENSG00000089289 ENSMUSG00000031221 UniProt P78318 Q61249 RefSeq (mRNA) NM_001551 NM_001370192 NM_001370193 NM_001370194 NM_008784 RefSeq (protein) NP_001542 NP_001357121 NP_001357122 NP_001357123 NP_032810 Location (UCSC) Chr X: 70.13 – 70.17 Mb Chr X: 99.54 – 99.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.^[6]

Interactions

IGBP1 has been shown to interact with PPP4C,^[7][8][9] PPP6C^[8][9] and PPP2CA.^{[8][9][10][11]}

References

1. GRCh38: Ensembl release 89: ENSG00000089289 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031221 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N (Dec 1997). "Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway". Genomics. 46 (3): 373–8. doi:10.1006/geno.1997.5048. PMID 9441740.
6. "Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1".
7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
8. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. S2CID 7531012.
9. Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
10. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
11. Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry. 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.

Further reading

• Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Chung H, Nairn AC, Murata K, Brautigan DL (Aug 1999). "Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2". Biochemistry. 38 (32): 10371–6. doi:10.1021/bi990902g. PMID 10441131.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL (Jun 2001). "Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4". Proceedings of the National Academy of Sciences of the United States of America. 98 (12): 6650–5. Bibcode:2001PNAS...98.6650L. doi:10.1073/pnas.111154698. PMC 34408. PMID 11371618.
• Short KM, Hopwood B, Yi Z, Cox TC (2002). "MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders". BMC Cell Biology. 3: 1. doi:10.1186/1471-2121-3-1. PMC 64779. PMID 11806752.
• Graham JM, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC (Nov 2003). "A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13". American Journal of Medical Genetics Part A. 123A (1): 37–44. doi:10.1002/ajmg.a.20504. PMID 14556245. S2CID 26545089.
• Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI (Apr 2006). "Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1764 (4): 724–34. doi:10.1016/j.bbapap.2006.01.018. PMID 16517231.