T-complex 1

In humans, the gene T-complex 1, a.k.a. TCP1, encodes the protein TCP-1^[a], a.k.a. T-complex protein 1 subunit alpha.^[5][6][7]

TCP1
Identifiers
Aliases	TCP1, CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha, T-complex 1
External IDs	OMIM: 186980; MGI: 98535; HomoloGene: 5656; GeneCards: TCP1; OMA:TCP1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 159,778,498 bp[1] End 159,789,703 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.72 cM Start 13,134,588 bp[2] End 13,143,954 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence left testis right testis ventricular zone left ovary gastric mucosa right ovary body of pancreas skin of abdomen Top expressed in spermatid spermatocyte testicle lens genital tubercle epiblast tail of embryo neural tube Mesencephalon ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding ubiquitin protein ligase binding protein folding chaperone activity unfolded protein binding RNA binding Cellular component cytoplasm cell body cytosol centrosome Golgi apparatus pericentriolar material myelin sheath microtubule organizing center zona pellucida receptor complex heterochromatin acrosomal vesicle chaperonin-containing T-complex microtubule extracellular exosome cytoskeleton Biological process tubulin complex assembly positive regulation of protein localization to Cajal body positive regulation of establishment of protein localization to telomere scaRNA localization to Cajal body regulation of macrophage apoptotic process protein stabilization positive regulation of telomere maintenance via telomerase toxin transport protein folding positive regulation of telomerase activity translocation of peptides or proteins into host cell cytoplasm positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida 'de novo' protein folding chaperone-mediated protein folding interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6950 21454 Ensembl ENSG00000120438 ENSMUSG00000068039 UniProt P17987 P11983 RefSeq (mRNA) NM_030752 NM_001008897 NM_001290712 NM_013686 RefSeq (protein) NP_001008897 NP_110379 NP_001277641 NP_038714 Location (UCSC) Chr 6: 159.78 – 159.79 Mb Chr 17: 13.13 – 13.14 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[7]

Interactions

T-complex 1 has been shown to interact with PPP4C^[8][9] and HDAC3.^[10] CCT also directly interacts with lectin type oxidized LDL receptor-1 (LOX-1) while its ligand oxidized low density lipoprotein (OxLDL) disassociates CCT from LOX-1.^[11]

Notes

1. The term "TCP-1" is variously expanded as "T-complex protein 1" and "tailless complex polypeptide 1". The "T-complex" is the same as tailless complex, a CCT locus associated with tail length in mice.