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From Wikipedia, the free encyclopedia
A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin.[3] The C-type designation is from their requirement for calcium for binding.[4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis.[5][6]
Drickamer et al. classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein.[7] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV).[8] Most recently, three further subgroups were added (XV to XVII).[3]
Group | Name | Associated domains |
---|---|---|
I | Lecticans | EGF, Sushi, Ig and Link domains |
II | Asialoglycoprotein and DC receptors | None |
III | Collectins | None |
IV | Selectins | Sushi and EGF domains |
V | NK - cell receptors | None |
VI | Multi-CTLD endocytic receptors | FnII and Ricin domains |
VII | Reg group | None |
VIII | Chondrolectin, Layilin | None |
IX | Tetranectin | None |
X | Polycystin | WSC, REJ, PKD domains |
XI | Attractin (ATRN) | PSI, EGF and CUB domains |
XII | Eosinophil major basic protein (EMBP) | None |
XIII | DGCR2 | None |
XIV | Thrombomodulin, CD93, CD248, CLEC14A | EGF domains [9] |
XV | Bimlec | None |
XVI | SEEC | SCP and EGF domains |
XVII | CBCP/Frem1/QBRICK | CSPG repeats and CalX-beta domains |
CLECs include:
The "NK Cell lectin-like receptors" are a very closely related group:[10]
Additional proteins containing this domain include:
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