CLEC9A

C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene.^[5]

CLEC9A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VPP
Identifiers
Aliases	CLEC9A, DNGR1, UNQ9341, CD370, DNGR-1, C-type lectin domain family 9 member A, C-type lectin domain containing 9A
External IDs	OMIM: 612252; MGI: 2444608; HomoloGene: 52106; GeneCards: CLEC9A; OMA:CLEC9A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,030,678 bp[1] End 10,066,031 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 129,385,825 bp[2] End 129,401,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad lymph node C1 segment substantia nigra monocyte smooth muscle tissue appendix thymus gallbladder Top expressed in spleen lung granulocyte liver ovary embryo bone marrow thymus ileum jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding Cellular component integral component of membrane membrane cell surface Biological process endocytosis receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283420 232414 Ensembl ENSG00000197992 ENSMUSG00000046080 UniProt Q6UXN8 Q8BRU4 RefSeq (mRNA) NM_207345 NM_001205363 NM_001205364 NM_001205365 NM_172732 RefSeq (protein) NP_997228 NP_001192292 NP_001192293 NP_001192294 NP_766320 Location (UCSC) Chr 12: 10.03 – 10.07 Mb Chr 6: 129.39 – 129.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000197992 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046080 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: C-type lectin domain family 9 member A". Retrieved 2016-06-02.
6. Zanders, Edward D. (2015-11-09). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. ISBN 978-1-118-84985-9.

Further reading

• Huysamen C, Willment JA, Dennehy KM, Brown GD (2008). "CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes". J. Biol. Chem. 283 (24): 16693–701. doi:10.1074/jbc.M709923200. PMC 2562446. PMID 18408006.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human C-type lectin domain family 9 member A (CLEC9A)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.