ZNF664

Protein cinkovog prsta 664 je protein koji je kod ljudi kodiran genom ZNF664.^[5][6] Određeno je da gen ZNF664 ima sedam egzon i raspon od 42,3 kb. Analizom somatskih hibrida i FISH-a, gen ZNF664 mapiran je na hromosomu 12, sekvenca q24.3.

ZNF664
Identifikatori
Aliasi	ZNF664
Vanjski ID-jevi	OMIM: 617890 MGI: 2442505 HomoloGene: 65046 GeneCards: ZNF664
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12q24.31 Početak 123,971,845 bp[1] Kraj 124,015,439 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 G1.1 Početak 124,939,755 bp[2] Kraj 124,979,757 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • molekularna funkcija • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • jedro Biološki proces • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:0022610 biološki proces • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	144348	269704
Ensembl	ENSG00000179195	ENSMUSG00000079215
UniProt	Q8N3J9	Q4VA44
RefSeq (mRNK)	NM_152437 NM_001204298	NM_001081750
RefSeq (bjelančevina)	NP_001191227 NP_689650	NP_001075219
Lokacija (UCSC)	Chr 12: 123.97 – 124.02 Mb	Chr 5: 124.94 – 124.98 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 261 aminokiselina, a molekulska težina 30.284 Da.^[7].

10		20		30		40		50
MIYKCPMCRE		FFSERADLFM		HQKIHTAEKP		HKCDKCDKGF		FHISELHIHW
RDHTGEKVYK		CDDCGKDFST		TTKLNRHKKI		HTVEKPYKCY		ECGKAFNWSS
HLQIHMRVHT		GEKPYVCSEC		GRGFSNSSNL		CMHQRVHTGE		KPFKCEECGK
AFRHTSSLCM		HQRVHTGEKP		YKCYECGKAF		SQSSSLCIHQ		RVHTGEKPYR
CCGCGKAFSQ		SSSLCIHQRV		HTGEKPFKCD		ECGKAFSQST		SLCIHQRVHT
KERNHLKISV		I

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1. GRCh38: Ensembl release 89: ENSG00000179195 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079215 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
6. "Entrez Gene: ZNF664 zinc finger protein 664".
7. "UniProt, Q8N3J9". Pristupljeno 8. 8. 2021.

Dopunska literatura

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Rivolta MN, Negrini C, Wilcox ER (1996). "A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3". Biochim. Biophys. Acta. 1306 (2–3): 127–32. doi:10.1016/0167-4781(96)00022-x. PMID 8634327.