RERG

RAS-oliki, estrogen-regulirani inhibitor rasta je protein koji je kod ljudi kodiran genom RERG.^[5]

RERG
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2ATV
Identifikatori
Aliasi	RERG
Vanjski ID-jevi	OMIM: 612664 MGI: 2665139 HomoloGene: 50026 GeneCards: RERG
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12p12.3 Početak 15,107,783 bp[1] Kraj 15,348,675 bp[1]
Lokacija gena (miš) Hrom. Hromosom 6 (miš)[2] Bend 6|6 G1 Početak 137,031,823 bp[2] Kraj 137,147,495 bp[2]
Ontologija gena Molekularna funkcija • nucleotide binding • GTP binding • GDP binding • estrogen receptor binding • GO:0006184 GTPase activity Ćelijska komponenta • citosol • jedro • membrana • citoplazma • ćelijska membrana Biološki proces • negative regulation of cell population proliferation • response to hormone • negative regulation of cell growth • GO:0072468 Transdukcija signala • small GTPase mediated signal transduction • Ras protein signal transduction Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	85004	232441
Ensembl	ENSG00000134533	ENSMUSG00000030222
UniProt	Q96A58	Q8R367
RefSeq (mRNK)	NM_001190726 NM_032918	NM_001164212 NM_001164214 NM_181988
RefSeq (bjelančevina)	NP_001177655 NP_116307	NP_001157684 NP_001157686 NP_871788
Lokacija (UCSC)	Chr 12: 15.11 – 15.35 Mb	Chr 6: 137.03 – 137.15 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

RERG, član superporodice RAS GTPaza, inhibira ćelijsku proliferaciju i formiranje tumora (Finlin et al., 2001 PubMed 11533059]).(prema OMIM, mart 2009).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 199 aminokiselina, a molekulska težina 22.608 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin

P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAKSAEVKLA		IFGRAGVGKS		ALVVRFLTKR		FIWEYDPTLE		STYRHQATID
DEVVSMEILD		TAGQEDTIQR		EGHMRWGEGF		VLVYDITDRG		SFEEVLPLKN
ILDEIKKPKN		VTLILVGNKA		DLDHSRQVST		EEGEKLATEL		ACAFYECSAC
TGEGNITEIF		YELCREVRRR		RMVQGKTRRR		SSTTHVKQAI		NKMLTKISS

Reference

1. GRCh38: Ensembl release 89: ENSG00000134533 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030222 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAS-like, estrogen-regulated, growth inhibitor". Pristupljeno 9. 11. 2012.
6. "UniProt, Q96A58". Pristupljeno 14. 8. 2021.

Vanjski linkovi

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ras-related and estrogen-regulated growth inhibitor (RERG)