PRB3

Bazni pljuvačni prolinom bogati protein 3 je protein koji je kod ljudi kodiran genom PRB3.^[3][4]

PRB3
Identifikatori
Aliasi	PRB3
Vanjski ID-jevi	OMIM: 168840 HomoloGene: 133260 GeneCards: PRB3
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12p13.2 Početak 11,265,914 bp[1] Kraj 11,269,707 bp[1]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ortolozi
Vrste	Čovjek	Miš
Entrez	5544	n/a
Ensembl	ENSG00000197870 ENSG00000275624	n/a
UniProt	Q04118	n/a
RefSeq (mRNK)	NM_006249 NM_001394862	n/a
RefSeq (bjelančevina)	n/a	n/a
Lokacija (UCSC)	Chr 12: 11.27 – 11.27 Mb	n/a
PubMed pretraga	[2]	n/a
Wikipodaci
Pogledaj/uredi – čovjek

Protein kodiran ovim genom je pljuvačni protein bogat prolin om. Glavni je sastojak parotidne pljuvačke. Predloženo je da ovaj protein djeluje kao bakterijski receptor. Ovaj i pet drugih gena koji također kodiraju pljuvačne proteine bogate prolinom (PRP), kao i gen koji kodira suznu žlijezdu PRP, čine klaster gena PRP u regiji 12p13 hromosoma 12.^[4]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 309 aminokiselina, a molekulska težina 30.980 Da.^[5].

10		20		30		40		50
MLLILLSVAL		LALSSAQSLN		EDVSQEESPS		VISGKPEGRR		PQGGNQPQRT
PPPPGKPEGR		PPQGGNQSQG		PPPRPGKPEG		PPPQGGNQSQ		GPPPRPGKPE
GQPPQGGNQS		QGPPPRPGKP		EGPPPQGGNQ		SQGPPPRPGK		PEGPPPQGGN
QSQGPPPHPG		KPEGPPPQGG		NQSQGPPPRP		GKPEGPPPQG		GNQSQGPPPR
PGKPEGPPPQ		GGNQSQGPPP		RPGKPEGSPS		QGGNKPQGPP		PHPGKPQGPP
PQEGNKPQRP		PPPGRPQGPP		PPGGNPQQPL		PPPAGKPQGP		PPPPQGGRPH
RPPQGQPPQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1. ENSG00000275624 GRCh38: Ensembl release 89: ENSG00000197870, ENSG00000275624 - Ensembl, maj 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ (Oct 1991). "Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein". J Biol Chem. 266 (26): 17358–68. PMID 1894623.
4. "Entrez Gene: PRB3 proline-rich protein BstNI subfamily 3".
5. "UniProt, Q04118". Pristupljeno 13. 8. 2021.

Dopunska literatura

• Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their polymorphisms". Adv. Hum. Genet. 17: 141–99. doi:10.1007/978-1-4613-0987-1_5. ISBN 978-1-4612-8279-2. PMID 3055850.
• Azen EA, Minaguchi K, Latreille P, Kim HS (1990). "Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew". Am. J. Hum. Genet. 47 (4): 686–97. PMC 1683781. PMID 2171329.
• Lyons KM, Stein JH, Smithies O (1989). "Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over". Genetics. 120 (1): 267–78. PMC 1203497. PMID 2851479.
• Maeda N, Kim HS, Azen EA, Smithies O (1985). "Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system". J. Biol. Chem. 260 (20): 11123–30. PMID 2993301.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Azen E, Prakobphol A, Fisher SJ (1993). "PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro". Infect. Immun. 61 (10): 4434–9. doi:10.1128/IAI.61.10.4434-4439.1993. PMC 281176. PMID 8406834.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.