APOF

Apolipoprotein F
Apolipoprotein F
Identifikatori
Simbol	APOF

APOF
Identifikatori
Aliasi	APOF
Vanjski ID-jevi	OMIM: 107760 MGI: 104539 HomoloGene: 48030 GeneCards: APOF
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	56,362,857 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	128,106,022 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cholesterol binding; • signaling receptor binding; • lipid transporter activity;
Ćelijska komponenta	• low-density lipoprotein particle; • high-density lipoprotein particle; • extracellular region; • Vanćelijsko;
Biološki proces	• steroid metabolic process; • lipid transport; • cholesterol metabolic process; • lipid metabolism;
	Izvori:Amigo / QuickGO
Ortolozi
	319
	103161
	ENSG00000175336
	ENSMUSG00000047631
	Q13790
	Q91V80
	NM_001638
	NM_133997
	NP_001629
	NP_598758
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Apolipoprotein F je protein koji je kod ljudi kodiran genom APOF.^[5]^[6]

Kratke činjenice Identifikatori, Aliasi ...

Zatvori

Kratke činjenice Apolipoprotein F, Identifikatori ...

Zatvori

Proizvod ovog gena jedan je od manjih apolipoproteina pronađenih u plazmi. Ovaj protein formira multiproteinska komplekse sa lipoproteinima i može biti uključen u transport i/ili esterifikaciju holesterola.^[6]

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Dužina polipeptidnog lanca je 326 aminokiselina, a molekulska težina 35.399 Da.^[7]

10	20	30	40	50
MTGLCGYSAP	DMRGLRLIMI	PVELLLCYLL	LHPVDATSYG	KQTNVLMHFP
LSLESQTPSS	DPLSCQFLHP	KSLPGFSHMA	PLPKFLVSLA	LRNALEEAGC
QADVWALQLQ	LYRQGGVNAT	QVLIQHLRGL	QKGRSTERNV	SVEALASALQ
LLAREQQSTG	RVGRSLPTED	CENEKEQAVH	NVVQLLPGVG	TFYNLGTALY
YATQNCLGKA	RERGRDGAID	LGYDLLMTMA	GMSGGPMGLA	ISAALKPALR
SGVQQLIQYY	QDQKDANISQ	PETTKEGLRA	ISDVSDLEET	TTLASFISEV
VSSAPYWGWA	IIKSYDLDPG	AGSLEI

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

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[1]
GRCh38: Ensembl release 89: ENSG00000175336 - Ensembl, maj 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000047631 - Ensembl, maj 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
[6]
"Entrez Gene: APOF apolipoprotein F".
[7]
"UniProt, Q13790". Pristupljeno 6. 8. 2021.

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Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102. S2CID 27752858.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry. 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry. 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.

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Lokacija ljudskog genoma APOF i stranica sa detaljima o genu APOF u UCSC Genome Browseru.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000175336 - Ensembl, maj 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000047631 - Ensembl, maj 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8093033-5] [5]
Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.

[entrez-6] [6]
"Entrez Gene: APOF apolipoprotein F".

[UniProt-7] [7]
"UniProt, Q13790". Pristupljeno 6. 8. 2021.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

APOF

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APOF

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Aminokiselinska sekvenca

Reference

Dopunska literatura

Vanjski linkovi