ACOX3

Peroksisomska acil-koenzmska A oksidaza 3 jest enzim koji je kod ljudi kodiran genom ACOX3 sa hromosoma 4.^[5][6]

ACOX3
Identifikatori
Aliasi	ACOX3
Vanjski ID-jevi	OMIM: 603402 MGI: 1933156 HomoloGene: 37792 GeneCards: ACOX3
Lokacija gena (čovjek) Hrom. Hromosom 4 (čovjek)[1] Bend 4p16.1 Početak 8,366,282 bp[1] Kraj 8,440,723 bp[1]
Lokacija gena (miš) Hrom. Hromosom 5 (miš)[2] Bend 5|5 B3 Početak 35,740,384 bp[2] Kraj 35,772,696 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • oxidoreductase activity, acting on the CH-CH group of donors • acyl-CoA oxidase activity • oxidoreductase activity • signaling receptor binding • pristanoyl-CoA oxidase activity • FAD binding • acyl-CoA dehydrogenase activity • flavin adenine dinucleotide binding • fatty acid binding Ćelijska komponenta • membrana • Peroksisom • peroxisomal matrix • mitohondrija • citosol Biološki proces • lipid metabolism • fatty acid metabolic process • fatty acid beta-oxidation using acyl-CoA oxidase • fatty acid beta-oxidation • metabolizam • fatty acid beta-oxidation using acyl-CoA dehydrogenase • protein targeting to peroxisome • lipid homeostasis Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8310	80911
Ensembl	ENSG00000087008	ENSMUSG00000029098
UniProt	O15254	Q9EPL9
RefSeq (mRNK)	NM_001101667 NM_003501	NM_030721 NM_001357018 NM_001357019 NM_001357020
RefSeq (bjelančevina)	NP_001095137 NP_003492 NP_001362712 NP_001362713 NP_001362714 NP_001362715 NP_001362716 NP_001362717 NP_001362718 NP_001362719	NP_109646 NP_001343947 NP_001343948 NP_001343949
Lokacija (UCSC)	Chr 4: 8.37 – 8.44 Mb	Chr 5: 35.74 – 35.77 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 700 aminokiselina, а molekulska težina 77.629 Da.^[7]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MASTVEGGDT		ALLPEFPRGP		LDAYRARASF		SWKELALFTE		GEGMLRFKKT
IFSALENDPL		FARSPGADLS		LEKYRELNFL		RCKRIFEYDF		LSVEDMFKSP
LKVPALIQCL		GMYDSSLAAK		YLLHSLVFGS		AVYSSGSERH		LTYIQKIFRM
EIFGCFALTE		LSHGSNTKAI		RTTAHYDPAT		EEFIIHSPDF		EAAKFWVGNM
GKTATHAVVF		AKLCVPGDQC		HGLHPFIVQI		RDPKTLLPMP		GVMVGDIGKK
LGQNGLDNGF		AMFHKVRVPR		QSLLNRMGDV		TPEGTYVSPF		KDVRQRFGAS
LGSLSSGRVS		IVSLAILNLK		LAVAIALRFS		ATRRQFGPTE		EEEIPVLEYP
MQQWRLLPYL		AAVYALDHFS		KSLFLDLVEL		QRGLASGDRS		ARQAELGREI
HALASASKPL		ASWTTQQGIQ		ECREACGGHG		YLAMNRLGVL		RDDNDPNCTY
EGDNNILLQQ		TSNYLLGLLA		HQVHDGACFR		SPLKSVDFLD		AYPGILDQKF
EVSSVADCLD		SAVALAAYKW		LVCYLLRETY		QKLNQEKRSG		SSDFEARNKC
QVSHGRPLAL		AFVELTVVQR		FHEHVHQPSV		PPSLRAVLGR		LSALYALWSL
SRHAALLYRG		GYFSGEQAGE		VLESAVLALC		SQLKDDAVAL		VDVIAPPDFV
LDSPIGRADG		ELYKNLWGAV		LQESKVLERA		SWWPEFSVNK		PVIGSLKSKL

Funkcija

Acil-koenzim A oksidaza 3, također poznata kao pristanoil-CoA oksidaza (ACOX3) je uključena u desaturaciju 2-metil razgranatih masnih kiselina u peroksisomima. Za razliku od pacovakog homologa, ljudski gen je eksprimiran u vrlo malim količinama u jetri tako da se njegova iRNK nije mogla otkriti rutinskom Northern blot analizom, imunoblotingom za svoj proizvod ili mjerenjem enzimske aktivnosti. Međutim, ljudska cDNK koje kodira protein od 700 aminokiselina sa peroksisomnim ciljanim C-terminalnim tripeptidom SKL izolirana je i smatra se da se eksprimira pod posebnim uvjetima kao što su specifični razvojne faze ili za tkivo specifičan način u tkivima koja još nisu ispitana.^[6]

Također pogledajte

• ACOX1
• Acil-CoA oskidaza

Reference

1. GRCh38: Ensembl release 89: ENSG00000087008 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029098 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vanhooren JC, Marynen P, Mannaerts GP, Van Veldhoven PP (Sep 1997). "Evidence for the existence of a pristanoyl-CoA oxidase gene in man". Biochem J. 325 (3): 593–9. doi:10.1042/bj3250593. PMC 1218600. PMID 9271077.
6. "Entrez Gene: ACOX3 acyl-Coenzyme A oxidase 3, pristanoyl".
7. "UniProt, O15254" (jezik: engleski). Pristupljeno 21. 10. 2021.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Vanhove GF, Van Veldhoven PP, Fransen M, et al. (1993). "The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney". J. Biol. Chem. 268 (14): 10335–44. doi:10.1016/S0021-9258(18)82206-2. PMID 8387517.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zha S, Ferdinandusse S, Hicks JL, et al. (2005). "Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer". Prostate. 63 (4): 316–23. doi:10.1002/pros.20177. PMID 15599942. S2CID 44702394.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi

• Lokacija ljudskog genoma ACOX3 i stranica sa detaljima o genu ACOX3 u UCSC Genome Browseru.