Protein cinkovog prsta 268 je protein koji je kod ljudi kodiran genom ZNF268.[3][4]
Kratke činjenice Dostupne strukture, PDB ...
ZNF268 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Protein_ZNF268_PDB_2EL4.png/250px-Protein_ZNF268_PDB_2EL4.png) |
Dostupne strukture |
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PDB | Pretraga Human UniProta: PDBe RCSB |
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Spisak PDB ID kodova |
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2EL4, 2EL5, 2EL6, 2EM1, 2EMV, 2EMW, 2EMX, 2EMY, 2EN0, 2EN6, 2EN7, 2EOF, 2EOG, 2EOI, 2EOJ, 2EOK, 2EOL, 2EOP, 2EPV, 2EPW, 2EPY, 2YTF, 2YTQ |
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Identifikatori |
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Aliasi | ZNF268 |
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Vanjski ID-jevi | OMIM: 604753 HomoloGene: 124392 GeneCards: ZNF268 |
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Ontologija gena |
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Molekularna funkcija | • nucleic acid binding • vezivanje sa DNK • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • intracellular anatomical structure • citoplazma • actin cytoskeleton • jedro • citosol
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Biološki proces | • GO:0009373 regulation of transcription, DNA-templated • Ćelijska diferencijacija • positive regulation of protein phosphorylation • GO:1903364 positive regulation of protein catabolic process • regulation of protein heterodimerization activity • positive regulation of cell migration • cellular response to tumor necrosis factor • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of protein homodimerization activity • transcription, DNA-templated • positive regulation of cell differentiation • positive regulation of cell population proliferation • regulation of mitotic cell cycle • positive regulation of apoptotic process • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of NIK/NF-kappaB signaling
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 12: 133.18 – 133.21 Mb | n/a |
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PubMed pretraga | [2] | n/a |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 94 aminokiseline, a molekulska težina 11 068 Da.[5]
- Simboli
10 | | 20 | | 30 | | 40 | | 50 |
MDVFVDFTWE | | EWQLLDPAQK | | CLYRSVMLEN | | YSNLVSLGYQ | | HTKPDIIFKL |
EQGEELCMVQ | | AQVPNQTCPN | | TVWKIDDLMD | | WHQENKDKLG | | STAK |
Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
- Shao H, Zhu C, Zhao Z, et al. (2006). "KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains". Int. J. Mol. Med. 18 (3): 457–63. doi:10.3892/ijmm.18.3.457. PMID 16865230.
- Guo MX, Wang D, Shao HJ, et al. (2006). "Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element". J. Biol. Chem. 281 (34): 24623–36. doi:10.1074/jbc.M602753200. PMID 16787922.
- Sun Y, Shao H, Li Z, et al. (2005). "ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development". Int. J. Mol. Med. 14 (6): 971–5. doi:10.3892/ijmm.14.6.971. PMID 15547661.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sun Y, Gou DM, Liu H, et al. (2004). "The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor". IUBMB Life. 55 (3): 127–31. doi:10.1080/1521654031000110208. PMID 12822888. S2CID 43391168.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gou DM, Sun Y, Gao L, et al. (2001). "Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo". Biochim. Biophys. Acta. 1518 (3): 306–10. doi:10.1016/s0167-4781(01)00194-4. hdl:10397/34032. PMID 11311945.