Član 1 porodice 4 L6 transmembranskih proteina jest protein koji je kod ljudi kodiran genom TM4SF1 sa hromosoma 3.[5][6]
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Zatvori
Dužina polipeptidnog lanca je 202 aminokiseline, а molekulska težina 21.632 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MCYGKCARCI | | GHSLVGLALL | | CIAANILLYF | | PNGETKYASE | | NHLSRFVWFF |
SGIVGGGLLM | | LLPAFVFIGL | | EQDDCCGCCG | | HENCGKRCAM | | LSSVLAALIG |
IAGSGYCVIV | | AALGLAEGPL | | CLDSLGQWNY | | TFASTEGQYL | | LDTSTWSECT |
EPKHIVEWNV | | SLFSILLALG | | GIEFILCLIQ | | VINGVLGGIC | | GFCCSHQQQY |
DC |
Protein kodiran ovim genom je član natporodice 4 transmembranskih proteina, poznate i kao porodica tetraspanina . Većina ovih članova su proteini na površini ćelije koje karakteriše prisustvo četiri hidrofobna domena. Proteini posreduju u događajima transdukcije signala koji imaju ulogu u regulaciji razvoja, aktivacije, rasta i pokretljivosti ćelija. Ovaj kodirani protein je antigen ćelijske površine i visoko je eksprimiran u različitim karcinomima.[6]
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- Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J (Jul 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
- Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N (Dec 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–8. PMID 11774983.
- Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–16. PMID 12855661.
- Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828. S2CID 26010618.
- Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC (Jun 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14 (8): 1868–76. doi:10.1158/1535-7163.MCT-15-0188. PMID 26089370.