TELO2

TEL2 homolog regulacijskog proteina telomerne dužine je protein koji je kod ljudi kodiran genom TELO2.^[5][6][7][8]

TELO2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4PSI
Identifikatori
Aliasi	TELO2
Vanjski ID-jevi	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek)[1] Bend 16p13.3 Početak 1,493,344 bp[1] Kraj 1,510,457 bp[1]
Lokacija gena (miš) Hrom. Hromosom 17 (miš)[2] Bend 17|17 A3.3 Početak 25,318,544 bp[2] Kraj 25,334,941 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0032947 molecular adaptor activity • Hsp90 protein binding • GO:0001948, GO:0016582 vezivanje za proteine • protein kinase binding • GO:0032403 protein-containing complex binding • telomeric DNA binding Ćelijska komponenta • citoplazma • Telomera • TORC1 complex • TORC2 complex • intracellular anatomical structure • membrana • nuclear periphery • jedro • hromosom • citosol • nuclear body • ASTRA complex Biološki proces • positive regulation of TORC1 signaling • protein stabilization • regulation of TOR signaling • positive regulation of TORC2 signaling • positive regulation of protein serine/threonine kinase activity • telomere maintenance Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9894	71718
Ensembl	ENSG00000100726	ENSMUSG00000024170
UniProt	Q9Y4R8	Q9DC40
RefSeq (mRNK)	NM_016111 NM_001351846	NM_001163661 NM_027880
RefSeq (bjelančevina)	NP_057195 NP_001338775	NP_001157133 NP_082156
Lokacija (UCSC)	Chr 16: 1.49 – 1.51 Mb	Chr 17: 25.32 – 25.33 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 837 aminokiselina, a molekulska težina 91.747 Da.^[9].

10		20		30		40		50
MEPAPSEVRL		AVREAIHALS		SSEDGGHIFC		TLESLKRYLG		EMEPPALPRE
KEEFASAHFS		PVLRCLASRL		SPAWLELLPH		GRLEELWASF		FLEGPADQAF
LVLMETIEGA		AGPSFRLMKM		ARLLARFLRE		GRLAVLMEAQ		CRQQTQPGFI
LLRETLLGKV		VALPDHLGNR		LQQENLAEFF		PQNYFRLLGE		EVVRVLQAVV
DSLQGGLDSS		VSFVSQVLGK		ACVHGRQQEI		LGVLVPRLAA		LTQGSYLHQR
VCWRLVEQVP		DRAMEAVLTG		LVEAALGPEV		LSRLLGNLVV		KNKKAQFVMT
QKLLFLQSRL		TTPMLQSLLG		HLAMDSQRRP		LLLQVLKELL		ETWGSSSAIR
HTPLPQQRHV		SKAVLICLAQ		LGEPELRDSR		DELLASMMAG		VKCRLDSSLP
PVRRLGMIVA		EVVSARIHPE		GPPLKFQYEE		DELSLELLAL		ASPQPAGDGA
SEAGTSLVPA		TAEPPAETPA		EIVDGGVPQA		QLAGSDSDLD		SDDEFVPYDM
SGDRELKSSK		APAYVRDCVE		ALTTSEDIER		WEAALRALEG		LVYRSPTATR
EVSVELAKVL		LHLEEKTCVV		GFAGLRQRAL		VAVTVTDPAP		VADYLTSQFY
ALNYSLRQRM		DILDVLTLAA		QELSRPGCLG		RTPQPGSPSP		NTPCLPEAAV
SQPGSAVASD		WRVVVEERIR		SKTQRLSKGG		PRQGPAGSPS		RFNSVAGHFF
FPLLQRFDRP		LVTFDLLGED		QLVLGRLAHT		LGALMCLAVN		TTVAVAMGKA
LLEFVWALRF		HIDAYVRQGL		LSAVSSVLLS		LPAARLLEDL		MDELLEARSW
LADVAEKDPD		EDCRTLALRA		LLLLQRLKNR		LLPPASP

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija

U 2007. istraživači su izvijestili o neočekivanoj ulozi Tel2 u ekspresiji svih proteinskih kinaza povezanih s sisarskim fosfatidilinozitol 3-kinazama (kinaza PIKK). Iako je Tel2 identificiran kao gen pupajućeg kvasca potreban za održavanje dužine telomera, nisu pronašli očiglednu telomernu funkciju sisarskog Tel2. Delecija Tel2 zaustavila je mTOR signalizaciju, ukazujući da Tel2 utiče na PIKK sisara. Tel2 se veže na dio HEAT-ponavljanja segmenata ATM-a i mTOR-a i visoko je konzervirani regulator stabilnosti PIKK-a.^[10]

Reference

1. GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
8. "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
9. "UniProt, Q9Y4R8". Pristupljeno 9. 7. 2021.
10. Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

Dopunska literatura

• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Vanjski linkovi

• Q9Y4R8