SLC9A4

Niskofinitetni natrij-glukozni kotransporter, znan i kao natrij/glukoza kotransporter 3 (SGLT3) ili član 4 poriodice 5 rastvornih nosača (SLC5A4) jest protein koji je kod ljudi kodiran genom SLC5A4 sa hromosoma 2.^[5][6][7] Funkcionira kao senzor šećera.

SLC9A4
Identifikatori
Aliasi	SLC9A4
Vanjski ID-jevi	OMIM: 600531 MGI: 105074 HomoloGene: 72232 GeneCards: SLC9A4
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek)[1] Bend 2q12.1 Početak 102,473,226 bp[1] Kraj 102,533,972 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1 B|1 19.51 cM Početak 40,619,241 bp[2] Kraj 40,669,885 bp[2]
Ontologija gena Molekularna funkcija • solute:proton antiporter activity • antiporter activity • sodium:proton antiporter activity • potassium:proton antiporter activity Ćelijska komponenta • integral component of membrane • basolateral plasma membrane • apical plasma membrane • membrana • ćelijska membrana Biološki proces • gastric acid secretion • proton transmembrane transport • epithelial cell development • cation transport • ion transport • regulation of pH • sodium ion transport • regulation of intracellular pH • sodium ion import across plasma membrane • potassium ion transmembrane transport • transmembrane transport • anion transmembrane transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	389015	110895
Ensembl	ENSG00000180251	ENSMUSG00000026065
UniProt	Q6AI14	Q8BUE1
RefSeq (mRNK)	NM_001011552	NM_177084
RefSeq (bjelančevina)	NP_001011552	NP_796058
Lokacija (UCSC)	Chr 2: 102.47 – 102.53 Mb	Chr 1: 40.62 – 40.67 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 659 aminokiselina, a molekulska težina 72.456 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MASTVSPSTI		AETPEPPPLS		DHIRNAADIS		VIVIYFLVVM		AVGLWAMLKT
NRGTIGGFFL		AGRDMAWWPM		GASLFASNIG		SNHYVGLAGT		GAASGVATVT
FEWTSSVMLL		ILGWIFVPIY		IKSGVMTMPE		YLKKRFGGER		LQVYLSILSL
FICVVLLISA		DIFAGAIFIK		LALGLDLYLA		IFILLAMTAV		YTTTGGLASV
IYTDTLQTII		MLIGSFILMG		FAFNEVGGYE		SFTEKYVNAT		PSVVEGDNLT
ISASCYTPRA		DSFHIFRDAV		TGDIPWPGII		FGMPITALWY		WCTNQVIVQR
CLCGKDMSHV		KAACIMCAYL		KLLPMFLMVM		PGMISRILYT		DMVACVVPSE
CVKHCGVDVG		CTNYAYPTMV		LELMPQGLRG		LMLSVMLASL		MSSLTSIFNS
ASTLFTIDLY		TKMRKQASEK		ELLIAGRIFV		LLLTVVSIVW		VPLVQVSQNG
QLIHYTESIS		SYLGPPIAAV		FVLAIFCKRV		NEQGAFWGLM		VGLAMGLIRM
ITEFAYGTGS		CLAPSNCPKI		ICGVHYLYFS		IVLFFGSMLV		TLGISLLTKP
IPDVHLYRLC		WVLRNSTEER		IDIDAEEKSQ		EETDDGVEED		YPEKSRGCLK
KAYDLFCGLQ		KGPKLTKEEE		EALSKKLTDT		SERPSWRTIV		NINAILLLAV
VVFIHGYYA

Reference

1. GRCh38: Ensembl release 89: ENSG00000180251 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026065 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
6. Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (mart 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
7. Jung H (oktobar 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.
8. "UniProt, Q9NY91" (jezik: engleski). Pristupljeno 19. 11. 2021.

Dpunska literatura

• Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503. S2CID 12803994.
• Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
• Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (septembar 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
• Fairchild TJ (januar 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (decembar 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (februar 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502. S2CID 13642065.

Vnjski ninkovi

Šablon:Porodica rastvornih nosača