Protein cinkovog prsta PLAGL1 jest protein koji je kod ljudi kodiran genom PLAGL1.[5][6][7]
Kratke činjenice Identifikatori, Aliasi ...
PLAGL1 |
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Identifikatori |
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Aliasi | PLAGL1 |
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Vanjski ID-jevi | OMIM: 603044 MGI: 1100874 HomoloGene: 31401 GeneCards: PLAGL1 |
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Ontologija gena |
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Molekularna funkcija | • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • nucleic acid binding • vezivanje iona metala • vezivanje sa DNK • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Ćelijska komponenta | • Golđijev aparat • intracellular membrane-bounded organelle • jedro • nukleoplazma • nuclear body
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Biološki proces | • Ćelijska diferencijacija • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0097285 apoptoza • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 6: 143.94 – 144.06 Mb | Chr 10: 13.06 – 13.13 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 463 aminokiseline, а molekulska težina 50.819 Da.[8]
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MATFPCQLCG | | KTFLTLEKFT | | IHNYSHSRER | | PYKCVQPDCG | | KAFVSRYKLM |
RHMATHSPQK | | SHQCAHCEKT | | FNRKDHLKNH | | LQTHDPNKMA | | FGCEECGKKY |
NTMLGYKRHL | | ALHAASSGDL | | TCGVCALELG | | STEVLLDHLK | | AHAEEKPPSG |
TKEKKHQCDH | | CERCFYTRKD | | VRRHLVVHTG | | CKDFLCQFCA | | QRFGRKDHLT |
RHTKKTHSQE | | LMKESLQTGD | | LLSTFHTISP | | SFQLKAAALP | | PFPLGASAQN |
GLASSLPAEV | | HSLTLSPPEQ | | AAQPMQPLPE | | SLASLHPSVS | | PGSPPPPLPN |
HKYNTTSTSY | | SPLASLPLKA | | DTKGFCNISL | | FEDLPLQEPQ | | SPQKLNPGFD |
LAKGNAGKVN | | LPKELPADAV | | NLTIPASLDL | | SPLLGFWQLP | | PPATQNTFGN |
STLALGPGES | | LPHRLSCLGQ | | QQQEPPLAMG | | TVSLGQLPLP | | PIPHVFSAGT |
GSAILPHFHH | | AFR |
Ovaj gen kodira C2H2 protein cinkovog prsta s transaktivacijom i vezanjem za DNK. Pokazalo se da pokazuje antiproliferativne aktivnosti i kandidat je za supresora tumora. Za ovaj gen pronađene su mnoge varijante transkripta koje kodiraju dvije različite izoforme.[7]
Pokazano je da PLAGL1 stupa u interakciju sa P53.[9]
- Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications". J Deaf Stud Deaf Educ. 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
- Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene. 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
- Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.
- Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226.
- Abdollahi A, Bao R, Hamilton TC (1999). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene. 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
- Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
- Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene. 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
- Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
- Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319. S2CID 22321580.
- Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
- Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI19876. PMC 484972. PMID 15286800.
- Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
- Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C (2004). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome". Diabetologia. 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.