PIP4K2C

Fosfatidilinozitol-5-fosfat 4-kinaza, tip II, gama je enzim koji je kod ljudi kodiran genom PIP4K2C.^[5] Jedan je od fosfatidilinozitol 4-fosfat 5-kinaza.

PIP4K2C
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2GK9
Identifikatori
Aliasi	PIP4K2C
Vanjski ID-jevi	OMIM: 617104 MGI: 2152214 HomoloGene: 23484 GeneCards: PIP4K2C
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek)[1] Bend 12q13.3 Početak 57,591,174 bp[1] Kraj 57,603,418 bp[1]
Lokacija gena (miš) Hrom. Hromosom 10 (miš)[2] Bend 10|10 D3 Početak 127,032,936 bp[2] Kraj 127,047,454 bp[2]
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • kinase activity • phosphatidylinositol phosphate kinase activity • vezivanje identičnih proteina • ATP binding • 1-phosphatidylinositol-5-phosphate 4-kinase activity Ćelijska komponenta • citoplazma • citosol • membrana • Autofagosom • Egzosom Biološki proces • phosphatidylinositol metabolic process • positive regulation of autophagosome assembly • Fosforilacija • phosphatidylinositol phosphate biosynthetic process • regulation of autophagy • phosphatidylinositol biosynthetic process • regulation of phosphatidylinositol 3-kinase signaling Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	79837	117150
Ensembl	ENSG00000166908	ENSMUSG00000025417
UniProt	Q8TBX8	Q91XU3
RefSeq (mRNK)	NM_001146258 NM_001146259 NM_001146260 NM_024779	NM_054097 NM_001359280
RefSeq (bjelančevina)	NP_001139730 NP_001139731 NP_001139732 NP_079055	NP_473438 NP_001346209
Lokacija (UCSC)	Chr 12: 57.59 – 57.6 Mb	Chr 10: 127.03 – 127.05 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 421 aminokiselina, a molekulska težina 47.300 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MASSSVPPAT		VSAATAGPGP		GFGFASKTKK		KHFVQQKVKV		FRAADPLVGV
FLWGVAHSIN		ELSQVPPPVM		LLPDDFKASS		KIKVNNHLFH		RENLPSHFKF
KEYCPQVFRN		LRDRFGIDDQ		DYLVSLTRNP		PSESEGSDGR		FLISYDRTLV
IKEVSSEDIA		DMHSNLSNYH		QYIVKCHGNT		LLPQFLGMYR		VSVDNEDSYM
LVMRNMFSHR		LPVHRKYDLK		GSLVSREASD		KEKVKELPTL		KDMDFLNKNQ
KVYIGEEEKK		IFLEKLKRDV		EFLVQLKIMD		YSLLLGIHDI		IRGSEPEEEA
PVREDESEVD		GDCSLTGPPA		LVGSYGTSPE		GIGGYIHSHR		PLGPGEFESF
IDVYAIRSAE		GAPQKEVYFM		GLIDILTQYD		AKKKAAHAAK		TVKHGAGAEI
STVHPEQYAK		RFLDFITNIF		A

Reference

1. GRCh38: Ensembl release 89: ENSG00000166908 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025417 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma".
6. "UniProt, Q8TBX8". Pristupljeno 12. 8. 2021.

Vanjski linkovi

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)

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