GLCE

D-glukuronil C5-epimeraza je enzim koji je kod ljudi kodiran genom GLCE.^[5][6]

GLCE
Identifikatori
Aliasi	GLCE
Vanjski ID-jevi	OMIM: 612134 MGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Lokacija gena (čovjek) Hrom. Hromosom 15 (čovjek)[1] Bend 15q23 Početak 69,160,584 bp[1] Kraj 69,272,217 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 B Početak 61,964,530 bp[2] Kraj 62,029,937 bp[2]
Ontologija gena Molekularna funkcija • racemase and epimerase activity, acting on carbohydrates and derivatives • isomerase activity • heparosan-N-sulfate-glucuronate 5-epimerase activity Ćelijska komponenta • integral component of membrane • Golđijeva membrana • Golđijev aparat • membrana Biološki proces • heparan sulfate proteoglycan biosynthetic process • heparin biosynthetic process • glycosaminoglycan biosynthetic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26035	93683
Ensembl	ENSG00000138604	ENSMUSG00000032252
UniProt	O94923	Q9EPS3
RefSeq (mRNK)	NM_015554 NM_001324091 NM_001324092 NM_001324093 NM_001324094	NM_033320 NM_001368304
RefSeq (bjelančevina)	NP_001311020 NP_001311021 NP_001311022 NP_001311023 NP_056369	NP_201577 NP_001355233
Lokacija (UCSC)	Chr 15: 69.16 – 69.27 Mb	Chr 9: 61.96 – 62.03 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 617 aminokiselina, a molekulska težina 70.101 Da.^[7]

10		20		30		40		50
MRCLAARVNY		KTLIIICALF		TLVTVLLWNK		CSSDKAIQFP		RRSSSGFRVD
GFEKRAAASE		SNNYMNHVAK		QQSEEAFPQE		QQKAPPVVGG		FNSNVGSKVL
GLKYEEIDCL		INDEHTIKGR		REGNEVFLPF		TWVEKYFDVY		GKVVQYDGYD
RFEFSHSYSK		VYAQRAPYHP		DGVFMSFEGY		NVEVRDRVKC		ISGVEGVPLS
TQWGPQGYFY		PIQIAQYGLS		HYSKNLTEKP		PHIEVYETAE		DRDKNKPNDW
TVPKGCFMAN		VADKSRFTNV		KQFIAPETSE		GVSLQLGNTK		DFIISFDLKF
LTNGSVSVVL		ETTEKNQLFT		IHYVSNAQLI		AFKERDIYYG		IGPRTSWSTV
TRDLVTDLRK		GVGLSNTKAV		KPTKIMPKKV		VRLIAKGKGF		LDNITISTTA
HMAAFFAASD		WLVRNQDEKG		GWPIMVTRKL		GEGFKSLEPG		WYSAMAQGQA
ISTLVRAYLL		TKDHIFLNSA		LRATAPYKFL		SEQHGVKAVF		MNKHDWYEEY
PTTPSSFVLN		GFMYSLIGLY		DLKETAGEKL		GKEARSLYER		GMESLKAMLP
LYDTGSGTIY		DLRHFMLGIA		PNLARWDYHT		THINQLQLLS		TIDESPVFKE
FVKRWKSYLK		GSRAKHN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1. GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.
6. "Entrez Gene: GLCE glucuronic acid epimerase".
7. "UniProt, O94923". Pristupljeno 14. 7. 2021.

Dopunska literatura

• Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi:10.1002/ijc.23203. PMID 17985344.
• Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi:10.1074/jbc.M313760200. PMID 14718527.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi:10.1074/jbc.M100880200. PMID 11279150.
• Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi:10.1074/jbc.M011783200. PMID 11274177.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.