Član A porodice sa sličnošću sekvence 49, znan i kao FAM49A, jest protein koji je kod ljudi kodiran genom FAM49A sa hromosoma 2.[5]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Dužina polipeptidnog lanca je 323 aminokiseline, a molkekulska iežina 37.313 Da.[6]
10 | | 20 | | 30 | | 40 | | 50 |
MGNLLKVLTR | | EIENYPHFFL | | DFENAQPTEG | | EREIWNQISA | | VLQDSESILA |
DLQAYKGAGP | | EIRDAIQNPN | | DIQLQEKAWN | | AVCPLVVRLK | | RFYEFSIRLE |
KALQSLLESL | | TCPPYTPTQH | | LEREQALAKE | | FAEILHFTLR | | FDELKMRNPA |
IQNDFSYYRR | | TISRNRINNM | | HLDIENEVNN | | EMANRMSLFY | | AEATPMLKTL |
SNATMHFVSE | | NKTLPIENTT | | DCLSTMTSVC | | KVMLETPEYR | | SRFTSEETLM |
FCMRVMVGVI | | ILYDHVHPVG | | AFCKTSKIDM | | KGCIKVLKEQ | | APDSVEGLLN |
ALRFTTKHLN | | DESTSKQIRA | | MLQ |
Fam49A se nalazi na ljudskom hromosomu 2, na poziciji 2p24.3. Ima 1512 parova baza u transkriptu referentne sekvence iRNK.[7]
Gen Fam49A proizvodi potein dužine 323 aminokiseline. Protein ima domene: ostaci 15-319 čine domen nepoznate funkcije (DUF1394, PF07159). Ostaci 67 → 281 čine natporodicu regije interaktivnog citoplazmatskog fragmenta fragilnog X, člana A porodice sa sličnošću sekvence 49.[8]
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.