Protein CREG1 (ćelijski represor E1A-stimuliranih gena 1) jest protein koji je kod ljudi kodiran genom CREG1 sa hromosoma 1.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
CREG1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Protein_CREG1_PDB_1xhn.png/250px-Protein_CREG1_PDB_1xhn.png) |
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Identifikatori |
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Aliasi | CREG1 |
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Vanjski ID-jevi | OMIM: 618055 MGI: 1344382 HomoloGene: 31199 GeneCards: CREG1 |
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Ontologija gena |
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Molekularna funkcija | • transcription factor binding • GO:0001106 transcription corepressor activity
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Ćelijska komponenta | • Egzosom • transcription regulator complex • extracellular region • Vanćelijsko • azurophil granule lumen
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Biološki proces | • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • multicellular organism development • regulation of growth • Ćelijska proliferacija • GO:0009373 regulation of transcription, DNA-templated • negative regulation of nucleic acid-templated transcription • neutrophil degranulation
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 1: 167.53 – 167.55 Mb | Chr 1: 165.59 – 165.6 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 220 aminokiselina, a molekulska težina 24.075 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MAGLSRGSAR | | ALLAALLAST | | LLALLVSPAR | | GRGGRDHGDW | | DEASRLPPLP |
PREDAARVAR | | FVTHVSDWGA | | LATISTLEAV | | RGRPFADVLS | | LSDGPPGAGS |
GVPYFYLSPL | | QLSVSNLQEN | | PYATLTMTLA | | QTNFCKKHGF | | DPQSPLCVHI |
MLSGTVTKVN | | ETEMDIAKHS | | LFIRHPEMKT | | WPSSHNWFFA | | KLNITNIWVL |
DYFGGPKIVT | | PEEYYNVTVQ |
Protein adenovirusa E1A istovremeno aktivira i potiskuje ekspresiju gena, kako bi promovirao ćelijsku proliferaciju i inhibirao diferencijaciju. Protein kodiran ovim genom antagonizira transkripcijsku aktivaciju i ćelijsku transformaciju pomoću E1A. Ovaj protein dijeli ograničenu sličnost sekvence sa E1A i vezuje se za opći transkripcijski faktor TBP i tumorski supresor pRb in vitro. Ovaj gen može doprinijeti transkripcijskoj kontroli rasta i ćelijske diferencijacije.[6]
- Veal E, Groisman R, Eisenstein M, Gill G (2000). "The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells". Oncogene. 19 (17): 2120–8. doi:10.1038/sj.onc.1203529. PMID 10815803.
- Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Di Bacco A, Gill G (2003). "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor". Oncogene. 22 (35): 5436–45. doi:10.1038/sj.onc.1206670. PMID 12934103.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Sacher M, Di Bacco A, Lunin VV, et al. (2006). "The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (51): 18326–31. doi:10.1073/pnas.0505071102. PMC 1317909. PMID 16344469.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.