Aftifilin jest protein koji je kod ljudi kodiran genom AFTPH sa hromosoma 3.[5][6][7][8]
Kratke činjenice Identifikatori, Aliasi ...
Zatvori
Kratke činjenice Aftifilinska klatrin-vezujuća kutija, Identifikatori ...
Aftifilinska klatrin-vezujuća kutija |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/09/Clathrine.jpg/220px-Clathrine.jpg) Klatrinski kompleks |
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Simbol | Clathrin_bdg |
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Zatvori
Dužina polipeptidnog lanca je 937 aminokiselina, а molekulska težina 102.200 Da.[9]
10 | | 20 | | 30 | | 40 | | 50 |
MEPDIIRMYS | | SSPPPLDNGA | | EDDDDDEFGE | | FGGFSEVSPS | | GVGFVDFDTP |
DYTRPKEEFV | | PSNHFMPIHE | | FSENVDSLTS | | FKSIKNGNDK | | DITAELSAPV |
KGQSDVLLST | | TSKEIISSEM | | LATSIDGMER | | PGNLNKVVEQ | | RQNVGTLESF |
SPGDFRTNMN | | VVHQNKQLES | | CNGEKPPCLE | | ILTNGFAVLE | | TVNPQGTDDL |
DNVADSKGRK | | PLSTHSTEYN | | LDSVPSPAEE | | FADFATFSKK | | ERIQLEEIEC |
AVLNDREALT | | IRENNKINRV | | NELNSVKEVA | | LGRSLDNKGD | | TDGEDQVCVS |
EISIVTNRGF | | SVEKQGLPTL | | QQDEFLQSGV | | QSKAWSLVDS | | ADNSEAIRRE |
QCKTEEKLDL | | LTSKCAHLCM | | DSVKTSDDEV | | GSPKEESRKF | | TNFQSPNIDP |
TEENDLDDSL | | SVKNGDSSND | | FVTCNDINED | | DFGDFGDFGS | | ASGSTPPFVT |
GTQDSMSDAT | | FEESSEHFPH | | FSEPGDDFGE | | FGDINAVSCQ | | EETILTKSDL |
KQTSDNLSEE | | CQLARKSSGT | | GTEPVAKLKN | | GQEGEIGHFD | | SVPNIQDDCN |
GFQDSDDFAD | | FSSAGPSQVV | | DWNAFEDEQK | | DSCSWAAFGD | | QQATESHHRK |
EAWQSHRTDE | | NIDTPGTPKT | | HSVPSATSKG | | AVASGHLQES | | ATSVQTALLN |
RLERIFEACF | | PSILVPDAEE | | EVTSLKHLLE | | TSTLPIKTRE | | ALPESGELLD |
VWTELQDIHD | | AHGLRYQWGG | | SHSNKKLLSS | | LGIDTRNILF | | TGNKKQPVIV |
PMYAAGLGML | | EPTKEPLKPL | | SAAEKIASIG | | QTATMSPDMN | | TCTSDQFQES |
LPPVQFDWSS | | SGLTNPLDAS | | GGSTLLNLDF | | FGPVDDSSSS | | SSTTIPGVDP |
ELYELTTSKL | | EISTSSLKVT | | DAFARLMSTV | | EKTSTSTSRK | | PKREEHLSEE |
AIKVIAGLPD | | LTFMHAKVLM | | FPATLTPSTS | | SQEKADG |
Aftifilin formira stabilan kompleks sa p200 i sinerginom gama.[6][7] Protein sadrži klatrinsku kutiju, sa dva identifikovana klatrin-vezujuća motiva i uključen je u promet vezikula.[10] Protein se nalazi u mnogim eukariotima.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.