Aktinu-srodni protein 2 jest protein koji je kod ljudi kodiran genom ACTR2 sa hromosoma 3.[5]
Kratke činjenice Dostupne strukture, PDB ...
ACTR2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/e/e3/Protein_ACTR2_PDB_1k8k.png/250px-Protein_ACTR2_PDB_1k8k.png) |
Dostupne strukture |
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PDB | Pretraga ortologa: PDBe RCSB |
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Spisak PDB ID kodova |
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2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI |
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Identifikatori |
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Aliasi | ACTR2 |
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Vanjski ID-jevi | OMIM: 604221 MGI: 1913963 HomoloGene: 4181 GeneCards: ACTR2 |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 2: 65.23 – 65.27 Mb | Chr 11: 20.01 – 20.06 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Zatvori
Dužina polipeptidnog lanca je 394 aminokiseline, а molekulska težina 44.761 Da.[6]
10 | | 20 | | 30 | | 40 | | 50 |
MDSQGRKVVV | | CDNGTGFVKC | | GYAGSNFPEH | | IFPALVGRPI | | IRSTTKVGNI |
EIKDLMVGDE | | ASELRSMLEV | | NYPMENGIVR | | NWDDMKHLWD | | YTFGPEKLNI |
DTRNCKILLT | | EPPMNPTKNR | | EKIVEVMFET | | YQFSGVYVAI | | QAVLTLYAQG |
LLTGVVVDSG | | DGVTHICPVY | | EGFSLPHLTR | | RLDIAGRDIT | | RYLIKLLLLR |
GYAFNHSADF | | ETVRMIKEKL | | CYVGYNIEQE | | QKLALETTVL | | VESYTLPDGR |
IIKVGGERFE | | APEALFQPHL | | INVEGVGVAE | | LLFNTIQAAD | | IDTRSEFYKH |
IVLSGGSTMY | | PGLPSRLERE | | LKQLYLERVL | | KGDVEKLSKF | | KIRIEDPPRR |
KHMVFLGGAV | | LADIMKDKDN | | FWMTRQEYQE | | KGVRVLEKLG | | VTVR |
Specifična funkcija ACTR2 još nije utvrđena. Međutim, poznato je da je glavni sastojak ARP2/3- kompleksa. Ovaj kompleks nalazi se na površini ćelije i neophodan je za oblik ćelije i pokretljivost kroz lamelipodijski aktinski sklop i izbočenje. Za ovaj genro, pnađene su dvije varijante transkripta koje kodiraju različite izoforme.[7]
- Bearer EL, Prakash JM, Li Z (2002). "Actin dynamics in platelets". Int. Rev. Cytol. International Review of Cytology. 217: 137–82. doi:10.1016/S0074-7696(02)17014-8. ISBN 9780123646217. PMC 3376087. PMID 12019562.
- Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes". Nature. 385 (6613): 265–9. Bibcode:1997Natur.385..265W. doi:10.1038/385265a0. PMID 9000076. S2CID 4358529.
- Winter D, Podtelejnikov AV, Mann M, Li R (1997). "The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches". Curr. Biol. 7 (7): 519–29. doi:10.1016/S0960-9822(06)00223-5. PMID 9210376. S2CID 52837402.
- Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328. ( Pt 1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
- Machesky LM, Insall RH (1999). "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex". Curr. Biol. 8 (25): 1347–56. doi:10.1016/S0960-9822(98)00015-3. PMID 9889097. S2CID 16661755.
- Suetsugu S, Miki H, Takenawa T (1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem. Biophys. Res. Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
- May RC, Hall ME, Higgs HN, et al. (1999). "The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes". Curr. Biol. 9 (14): 759–62. doi:10.1016/S0960-9822(99)80337-6. PMID 10421578. S2CID 17030983.
- Loisel TP, Boujemaa R, Pantaloni D, Carlier MF (1999). "Reconstitution of actin-based motility of Listeria and Shigella using pure proteins". Nature. 401 (6753): 613–6. Bibcode:1999Natur.401..613L. doi:10.1038/44183. PMID 10524632. S2CID 4313372.
- Higgs HN, Blanchoin L, Pollard TD (1999). "Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization". Biochemistry. 38 (46): 15212–22. doi:10.1021/bi991843. PMID 10563804.
- Carlier MF, Nioche P, Broutin-L'Hermite I, et al. (2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". J. Biol. Chem. 275 (29): 21946–52. doi:10.1074/jbc.M000687200. PMID 10781580.
- Weed SA, Karginov AV, Schafer DA, et al. (2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". J. Cell Biol. 151 (1): 29–40. doi:10.1083/jcb.151.1.29. PMC 2189811. PMID 11018051.
- Prehoda KE, Scott JA, Mullins RD, Lim WA (2000). "Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex". Science. 290 (5492): 801–6. Bibcode:2000Sci...290..801P. doi:10.1126/science.290.5492.801. PMID 11052943.
- Marchand JB, Kaiser DA, Pollard TD, Higgs HN (2001). "Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex". Nat. Cell Biol. 3 (1): 76–82. doi:10.1038/35050590. PMID 11146629. S2CID 30437883.
- Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547.
- Flanagan LA, Chou J, Falet H, et al. (2001). "Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells". J. Cell Biol. 155 (4): 511–7. doi:10.1083/jcb.200105148. PMC 2198874. PMID 11706047.
- Robinson RC, Turbedsky K, Kaiser DA, et al. (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–84. Bibcode:2001Sci...294.1679R. doi:10.1126/science.1066333. PMID 11721045. S2CID 18088124.
- Gournier H, Goley ED, Niederstrasser H, et al. (2002). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity". Mol. Cell. 8 (5): 1041–52. doi:10.1016/S1097-2765(01)00393-8. PMID 11741539.
- Li Z, Kim ES, Bearer EL (2002). "Arp2/3 complex is required for actin polymerization during platelet shape change". Blood. 99 (12): 4466–74. doi:10.1182/blood.V99.12.4466. PMC 3376088. PMID 12036877.
ACTR2 detalji ljudskog genoma u UCSC Genome Browser.