ACTR1B

ACTR1B
Identifikatori
Aliasi	ACTR1B
Vanjski ID-jevi	OMIM: 605144 MGI: 1917446 HomoloGene: 101541 GeneCards: ACTR1B
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	97,664,044 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	36,753,503 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • cytoskeletal protein-membrane anchor activity;
Ćelijska komponenta	• citoplazma; • microtubule cytoskeleton; • citosol; • centrosom; • Egzosom; • citoskelet; • membrana; • dynactin complex; • centar organizacije mikrotubula; • extracellular region; • secretory granule lumen; • ficolin-1-rich granule lumen; • cell cortex region;
Biološki proces	• antigen processing and presentation of exogenous peptide antigen via MHC class II; • neutrophil degranulation; • establishment of mitotic spindle orientation; • nuclear migration along microtubule;
	Izvori:Amigo / QuickGO
Ortolozi
	10120
	226977
	ENSG00000115073
	ENSMUSG00000037351
	P42025
	Q8R5C5
	NM_005735
	NM_146107
	NP_005726
	NP_666219
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Beta-centraktin jest protein koji je kod ljudi kodiran genom ACTR1B sa hromosoma 2.^[5]^[6]^[7]

Kratke činjenice Identifikatori, Aliasi ...

Zatvori

Ovaj gen kodira podjedinicu dinaktina od 42,3 kD, makromolekulski kompleks koji se sastoji od 10 podjedinica veličine od 22 do 150 kD. Dinaktin se vezuje za mikrotubule i citoplazmatski dinein. Uključen je u različite ćelijske funkcije, uključujući transport na relaciji ER – Golgijev aparat, centripetalnim pokretom lizosoma i endosoma, formiranja vretena, kretanja hromosoma, iedarnog pozicioniranja i aksonogeneze. Ova podjedinica, poput ACTR1A, je protein vezan za aktin. Ova dva proteina su jednake dužine i dijele 90% aminokiselinskog identiteta. Prisutni su u kompleksu dinaktina, u konstantnom omjeru od približno 1:15.^[7]

[1]
GRCh38: Ensembl release 89: ENSG00000115073 - Ensembl, maj 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000037351 - Ensembl, maj 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
Clark SW, Staub O, Clark IB, Holzbaur EL, Paschal BM, Vallee RB, Meyer DI (maj 1995). "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell. 5 (12): 1301–10. doi:10.1091/mbc.5.12.1301. PMC 301159. PMID 7696711.
[6]
Elsea SH, Clark IB, Juyal RC, Meyer DJ, Meyer DI, Patel PI (Jun 1999). "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet. 84 (1–2): 48–9. doi:10.1159/000015211. PMID 10343100. S2CID 83665096.
[7]
"Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)".
[8]
"UniProt, P42025" (jezik: engleski). Pristupljeno 15. 11. 2021.

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Eckley DM, Schroer TA (2004). "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell. 14 (7): 2645–54. doi:10.1091/mbc.E03-01-0049. PMC 165665. PMID 12857853.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.

ACTR1B detalji ljudskog genoma u UCSC Genome Browser.

Aminokiselinska sekvenca