內皮唾液酸蛋白

內皮唾液酸蛋白（英語：Endosialin），也叫分化簇248、腫瘤內皮標誌物1（Tumor Endothelial Marker 1），是人類中由CD248基因編碼的蛋白質。^[5][6][7]

內皮唾液酸蛋白
識別號
別名	CD248；, CD164L1, TEM1, CD248 molecule
外部ID	OMIM：606064 MGI：1917695 HomoloGene：10699 GeneCards：CD248
基因位置（人類） 染色體 11號染色體[1] 基因座 11q13.2 起始 66,314,494 bp[1] 終止 66,317,044 bp[1]
基因位置（小鼠） 染色體 小鼠19號染色體[2] 基因座 19|19 A 起始 5,118,106 bp[2] 終止 5,120,710 bp[2]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • calcium ion binding • extracellular matrix binding • carbohydrate binding • 分子功能 • extracellular matrix protein binding 細胞組分 • 細胞質 • integral component of membrane • 外排體 • 膜 • 細胞外間質 • external side of plasma membrane 生物學過程 • positive regulation of endothelial cell apoptotic process • 淋巴結的發生 • 細胞遷移 • positive regulation of cell population proliferation • anatomical structure regression • 生物過程 Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	57124	70445
Ensembl	ENSG00000174807	ENSMUSG00000056481
UniProt	Q9HCU0	Q91V98
mRNA​序列	NM_020404	NM_054042
蛋白序列	NP_065137	NP_473383
基因位置​（UCSC）	Chr 11: 66.31 – 66.32 Mb	Chr 19: 5.12 – 5.12 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

內皮唾液酸蛋白是C型凝集素跨膜受體家族中「第XIV組」的成員，不僅在細胞間粘附過程中發揮作用，而且在宿主防禦中發揮作用。該組家族包括其他三個成員：CLEC14A、CD93和血栓調節蛋白，後者的特徵更為明確。^[8]

內皮唾液酸蛋白的功能仍然難以捉摸，但其表達與胚胎和子宮中的血管生成以及腫瘤的發育和生長有關。^[9]

參見

• 分化群

參考資料

1. GRCh38: Ensembl release 89: ENSG00000174807 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056481 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW. Genes expressed in human tumor endothelium. Science. Aug 2000, 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. PMID 10947988. doi:10.1126/science.289.5482.1197.
6. Christian S, Ahorn H, Koehler A, Eisenhaber F, Rodi HP, Garin-Chesa P, Park JE, Rettig WJ, Lenter MC. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J Biol Chem. May 2001, 276 (10): 7408–14. PMID 11084048. doi:10.1074/jbc.M009604200 .
7. Entrez Gene: CD248 CD248 molecule, endosialin. [2024-01-23]. （原始內容存檔於2010-12-05）.
8. Khan KA, McMurray J, Mohammed FM, Bicknell R. C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.. FEBS Journal. 2019, 286 (17): 3299–3332. PMC 6852297 . PMID 31287944. doi:10.1111/febs.14985.
9. Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P. Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis.. Cancer Immun. 2006, 6: 10. PMID 16875435.

延伸閱讀

• Rettig WJ, Garin-Chesa P, Healey JH, et al. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer.. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (22): 10832–6. Bibcode:1992PNAS...8910832R. PMC 50436 . PMID 1438285. doi:10.1073/pnas.89.22.10832 .
• Opavsky R, Haviernik P, Jurkovicova D, et al. Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo.. J. Biol. Chem. 2001, 276 (42): 38795–807. PMID 11489895. doi:10.1074/jbc.M105241200 .
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 .
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Brady J, Neal J, Sadakar N, Gasque P. Human endosialin (tumor endothelial marker 1) is abundantly expressed in highly malignant and invasive brain tumors.. J. Neuropathol. Exp. Neurol. 2005, 63 (12): 1274–83. PMID 15624764. doi:10.1093/jnen/63.12.1274 .
• MacFadyen JR, Haworth O, Roberston D, et al. Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. (PDF). FEBS Lett. 2005, 579 (12): 2569–75 [2024-01-23]. PMID 15862292. S2CID 11757246. doi:10.1016/j.febslet.2005.03.071 . （原始內容存檔 (PDF)於2020-02-19）.
• Dolznig H, Schweifer N, Puri C, et al. Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin.. Cancer Immun. 2006, 5: 10. PMID 16076089.
• Tomkowicz B, Rybinski K, Foley B, et al. Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.. Proc. Natl. Acad. Sci. U.S.A. 2008, 104 (46): 17965–70. PMC 2084280 . PMID 17986615. doi:10.1073/pnas.0705647104 .
• Khan KA, McMurray J, Mohammed FM, Bicknell R. C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation.. FEBS Journal. 2019, 286 (17): 3299–3332. PMC 6852297 . PMID 31287944. doi:10.1111/febs.14985.

外部連結

• 醫學主題詞表（MeSH）：CD248+protein,+human
• Human CD248 genome location and CD248 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.