ABL2

Tirozinska proteinska kinaza ABL2 (Abelsonu srodan gen, Arg) enzim je koji je kod ljudi kodiran ABL2 genom.^[1][2]

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ABL proto-onkogen 2, nereceptorska tirozinska kinaza
PDB prikaz baziran na 1ab2.
Dostupne strukture
2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Identifikatori
Simboli	ABL2; ABLL; ARG
Vanjski ID	OMIM: 164690 MGI: 87860 HomoloGene: 5278 GeneCards: ABL2 Gene
EC broj	2.7.10.2
Ontologija gena Molekulska funkcija • vezivanje magnezijumovog jona • vezivanje aktinskog monomera • aktivnost proteinske kinaze Ćelijska komponenta • citozol • aktinski citoskeleton Biološki proces • proces modifikacije ćelijskih proteina • ćelijska adhezija • prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	27	11352
Ensembl	ENSG00000143322	ENSMUSG00000026596
UniProt	P42684	Q4JIM5
Ref. Sekv. (iRNK)	NM_001136000	NM_001136104
Ref. Sekv. (protein)	NP_001129472	NP_001129576
Lokacija (UCSC)	Chr 1: 179.07 - 179.2 Mb	Chr 1: 156.56 - 156.65 Mb
PubMed pretraga

Funkciја

ABL2 je citoplazmatična tirozinska kinaza koja je blisko srodna sa, mada je distinktna od ABL1. Sličnost ovih proteina obuhvata tirozinske kinazne domene, kao i SH2 i SH3 domene. ABL2 biva izražena u normalnim i tumorskim ćelijama. ABL2 genski produkt se javlja u dve varijante koje imaju različite amino krajeve, duge oko 12-kb.^[2]

Interakcije

ABL2 formira interakcije sa tri proteina: Abl genom,^[3] katalazom,^[4] i SORBS2.^[5] Protein Abl gena je takođe poznat kao abelsonov mišji leukemijski viralni onkogeni homolog 1. On je kod ljudi kodiran kodiran ABL1 genom.^[6] Katalaza je enzim koji katalizuje dekompoziciju vodonik peroksida do vode i kiseonika.^[7] SORBS2 je takođe poznata kao Sorbin i SH3 domen-sadržavajući protein 2. Kod ljudi je ona kodirana SORBS2 genom.^[5][8][2]

Reference

1. Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, Aaronson SA (Jan 1987). „A novel human gene closely related to the abl proto-oncogene”. Science 234 (4783): 1545–8. DOI:10.1126/science.3787260. PMID 3787260.
2. „Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)”.
3. Cao C, Leng Y, Li C, Kufe D (April 2003). „Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response”. J. Biol. Chem. 278 (15): 12961–7. DOI:10.1074/jbc.M300058200. PMID 12569093.
4. Cao C, Leng Y, Kufe D (August 2003). „Catalase activity is regulated by c-Abl and Arg in the oxidative stress response”. J. Biol. Chem. 278 (32): 29667–75. DOI:10.1074/jbc.M301292200. PMID 12777400.
5. Wang B, Golemis EA, Kruh GD (July 1997). „ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks”. J. Biol. Chem. 272 (28): 17542–50. DOI:10.1074/jbc.272.28.17542. PMID 9211900.
6. Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, Gewirtz AM, Calabretta B (August 1991). „Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides”. Science 253 (5019): 562–5. DOI:10.1126/science.1857987. PMID 1857987.
7. Chelikani P, Fita I, Loewen PC (January 2004). „Diversity of structures and properties among catalases”. Cell. Mol. Life Sci. 61 (2): 192–208. DOI:10.1007/s00018-003-3206-5. PMID 14745498.
8. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). „Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res 5 (5): 277–86. DOI:10.1093/dnares/5.5.277. PMID 9872452.

Literatura

• Bradley, WD, Koleske AJ (2009). „Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts.”. J Cell Sci 122: 3441–54. DOI:10.1242/jcs.039859. PMC 2746129. PMID 19759284.
• Pendergast AM (2003). „The Abl family kinases: mechanisms of regulation and signaling.”. Adv. Cancer Res. 85: 51–100. DOI:10.1016/S0065-230X(02)85003-5. PMID 12374288.
• Muller AJ, Pendergast AM, Havlik MH, et al. (1992). „A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.”. Mol. Cell. Biol. 12 (11): 5087–93. PMC 360442. PMID 1383690.
• Kruh GD, Perego R, Miki T, Aaronson SA (1990). „The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.”. Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5802–6. DOI:10.1073/pnas.87.15.5802. PMC 54416. PMID 2198571.
• Kruh GD, King CR, Kraus MH, et al. (1987). „A novel human gene closely related to the abl proto-oncogene.”. Science 234 (4783): 1545–8. DOI:10.1126/science.3787260. PMID 3787260.
• Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wang B, Kruh GD (1996). „Subcellular localization of the Arg protein tyrosine kinase”. Oncogene 13 (1): 193–7. PMID 8700546.
• Wang B, Mysliwiec T, Feller SM, et al. (1996). „Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk”. Oncogene 13 (7): 1379–85. PMID 8875975.
• Wang B, Golemis EA, Kruh GD (1997). „ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks”. J. Biol. Chem. 272 (28): 17542–50. DOI:10.1074/jbc.272.28.17542. PMID 9211900.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Koval AP, Blakesley VA, Roberts CT, et al. (1998). „Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor”. Biochem. J. 330 (2): 923–32. PMC 1219226. PMID 9480911.
• Hashimoto Y, Katayama H, Kiyokawa E, et al. (1998). „Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor”. J. Biol. Chem. 273 (27): 17186–91. DOI:10.1074/jbc.273.27.17186. PMID 9642287.
• Danial NN, Losman JA, Lu T, et al. (1998). „Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation”. Mol. Cell. Biol. 18 (11): 6795–804. PMC 109263. PMID 9774693.
• Cao C, Ren X, Kharbanda S, et al. (2001). „The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress”. J. Biol. Chem. 276 (15): 11465–8. DOI:10.1074/jbc.C100050200. PMID 11278261.
• Yu HH, Zisch AH, Dodelet VC, Pasquale EB (2001). „Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor”. Oncogene 20 (30): 3995–4006. DOI:10.1038/sj.onc.1204524. PMID 11494128.
• Endo A, Nagashima K, Kurose H, et al. (2002). „Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII”. J. Biol. Chem. 277 (26): 23747–54. DOI:10.1074/jbc.M111794200. PMID 11956190.
• Abassi YA, Vuori K (2002). „Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling”. EMBO J. 21 (17): 4571–82. DOI:10.1093/emboj/cdf446. PMC 126186. PMID 12198159.
• Bianchi C, Muradore I, Corizzato M, et al. (2002). „The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation”. FEBS Lett. 527 (1–3): 216–222. DOI:10.1016/S0014-5793(02)03233-7. PMID 12220663.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salomon AR, Ficarro SB, Brill LM, et al. (2003). „Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry”. Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. DOI:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.

Vanjske veze

• MeSH Genes,+abl
• MeSH Abelson+Leukemia+Virus
• ABL2 Arhivirano 2011-07-04 na Wayback Machine-u Info with links in the Cell Migration Gateway Arhivirano 2014-12-11 na Wayback Machine-u