Interleukin-4

Interleukin-4, IL-4 (bahasa Inggris: BSF1, BCGF1, BCGF-1, MGC79402) adalah sitokina pleiotropik yang disekresi oleh sel T yang telah teraktivasi^[4] menjadi sel T_H2, bersama-sama dengan IL-5 dan IL-13.^[5] IL-4 berperan dominan dalam sistem kekebalan dan merupakan faktor yang penting dalam perkembangan hipersensitivitas,^[6] dengan fungsi seluler yang banyak tumpang-tindih dengan IL-13.^[4]

IL4
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK, 2D48, 2INT, 3BPL, 3BPN, 3QB7, 4YDY, 5FHX
Pengidentifikasi
Alias	IL4, Interleukin 4, IL-4
ID eksternal	MGI: 96556 HomoloGene: 491 GeneCards: IL4
Lokasi gen (Tikus) Kr. Kromosom 11 (tikus)[1] Pita 11 B1.3|11 31.97 cM Awal 53,493,809 bp[1] Akhir 53,509,496 bp[1]
Ontologi gen Fungsi molekuler • interleukin-4 receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma • growth factor activity • GO:0005145 cytokine receptor binding • cytokine activity Komponen seluler • extracellular region • extracellular space Proses biologis • positive regulation of T cell differentiation • dendritic cell differentiation • negative regulation of endothelial cell apoptotic process • negative regulation of complement-dependent cytotoxicity • regulation of phosphorylation • negative regulation of apoptotic process • myeloid dendritic cell differentiation • type 2 immune response • B cell activation • positive regulation of interleukin-13 production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • B cell differentiation • T-helper 2 cell cytokine production • regulation of isotype switching • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of epithelial cell migration • regulation of signaling receptor activity • cholesterol metabolic process • positive regulation of B cell proliferation • positive regulation of T cell proliferation • T cell activation • positive regulation of MHC class II biosynthetic process • negative regulation of osteoclast differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of isotype switching to IgE isotypes • positive regulation of isotype switching to IgG isotypes • regulation of immune response • cytokine-mediated signaling pathway • GO:1901313 positive regulation of gene expression • positive regulation of macroautophagy • positive regulation of tyrosine phosphorylation of STAT protein • activation of Janus kinase activity • positive regulation of receptor-mediated endocytosis • positive regulation of cold-induced thermogenesis • negative regulation of neuroinflammatory response • positive regulation of amyloid-beta clearance • neuroinflammatory response • positive regulation of cellular respiration • positive regulation of ATP biosynthetic process Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	3565	16189
Ensembl	ENSG00000113520	ENSMUSG00000000869
UniProt	P05112	P07750
RefSeq (mRNA)	NM_000589.4	NM_021283
RefSeq (protein)	NP_000580 NP_758858 NP_001341919	NP_067258
Lokasi (UCSC)	n/a	Chr 11: 53.49 – 53.51 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus