Interleukin-13

Interleukin-13, IL-13 adalah sebuah protein dengan fungsi sitokina yang disekresi berbagai sel, tetapi terutama oleh sel T_H2. Berbagai efek biologis IL-13, seperti halnya IL-4, terkait dengan sebuah faktor transkripsi yaitu STAT6.

IL13
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 1GA3, 1IJZ, 1IK0, 3BPO, 3G6D, 3L5W, 3L5X, 3LB6, 4I77, 4PS4, 5E4E
Pengidentifikasi
Alias	IL13, IL-13, P600, interleukin 13
ID eksternal	OMIM: 147683 MGI: 96541 HomoloGene: 1649 GeneCards: IL13
Lokasi gen (Tikus) Kr. Kromosom 11 (tikus)[1] Pita 11 B1.3|11 31.98 cM Awal 53,522,151 bp[1] Akhir 53,525,529 bp[1]
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • GO:0001948, GO:0016582 Ikatan protein plasma • GO:0005145 cytokine receptor binding • cytokine activity • interleukin-13 receptor binding Komponen seluler • sitoplasma • external side of plasma membrane • extracellular region • extracellular space Proses biologis • negative regulation of endothelial cell apoptotic process • negative regulation of complement-dependent cytotoxicity • negative regulation of transforming growth factor beta production • positive regulation of lung goblet cell differentiation • response to mechanical stimulus • response to nicotine • positive regulation of release of sequestered calcium ion into cytosol • microglial cell activation • negative regulation of NAD(P)H oxidase activity • cellular response to mechanical stimulus • response to lipopolysaccharide • negative regulation of lung ciliated cell differentiation • positive regulation of ion transport • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • positive regulation of protein secretion • positive regulation of connective tissue growth factor production • positive regulation of pancreatic stellate cell proliferation • response to ethanol • inflammatory response • regulation of proton transport • positive regulation of smooth muscle cell proliferation • negative regulation of neuron death • positive regulation of immunoglobulin production • positive regulation of B cell proliferation • positive regulation of macrophage activation • positive regulation of mast cell degranulation • cellular response to cytokine stimulus • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • cytokine-mediated signaling pathway • GO:1901313 positive regulation of gene expression • positive regulation of cold-induced thermogenesis Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	3596	16163
Ensembl	ENSG00000169194	ENSMUSG00000020383
UniProt	P35225	P20109
RefSeq (mRNA)	NM_002188	NM_008355
RefSeq (protein)	NP_002179 NP_001341920 NP_001341921 NP_001341922	NP_032381
Lokasi (UCSC)	n/a	Chr 11: 53.52 – 53.53 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus