MYCL

A proteína protooncoxénica L-myc-1 é unha proteína que nos humanos está codificada no xene MYCL (tamén MYCL1 ou L-Myc) do cromosoma 1.^[1][2]

Para a familia de xenes véxase: Myc.

MYCL
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Nomenclatura	Outros nomes MYCL, LMYC, MYCL1, bHLHe38, L-Myc, homólogo derivado do carcinoma pulmonar do oncoxene v-myc da mielocitomatose viral aviaria, MYCL proto-oncogene, factor de transcrición bHLH
Símbolos	MYCL (HGNC: 7555) MYCL, LMYC, MYCL1, bHLHe38, L-Myc, homólogo derivado do carcinoma pulmonar do oncoxene v-myc da mielocitomatose viral aviaria, MYCL proto-oncogene, factor de transcrición bHLH
Identificadores externos	OMIM: 164850 MGI: 96799 HomoloGene: 3921 EBI: MYCL GeneCards: Xene MYCL UniProt: MYCL
Locus	Cr. 1 p34.2
Ontoloxía Xénica Referencias: AmiGO / QuickGO
Ortólogos
Especies	Humano Rato
Entrez	4610 16918
Ensembl	Véxase HS Véxase MM
UniProt	P12524 P10166
RefSeq (ARNm)	NM_005376 NM_008506
RefSeq (proteína) NCBI	NP_001028253 NP_001290050
Localización (UCSC)	Cr. 1: 39.9 – 39.9 Mb Cr. 4: 122.89 – 122.9 Mb
PubMed (Busca)	4610 16918

Esta proteína é un factor de transcrición bHLH (hélice básica-bucle-hélice) implicado no cancro de pulmón.^[3]

Interaccións

Esta proteína presenta interaccións con MAX.^[4][5]

Notas

1. Speleman F, Van Camp G, Van Roy N (xaneiro de 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2–3): 189–190. PMID 8978772. doi:10.1159/000134185.
2. "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
3. Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. doi:10.1002/j.1460-2075.1989.tb03573.x.
4. Blackwood EM, Eisenman RN (marzo de 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science 251 (4998): 1211–1217. Bibcode:1991Sci...251.1211B. PMID 2006410. doi:10.1126/science.2006410.
5. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (abril de 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. PMID 10229200. doi:10.1038/sj.onc.1202611.

Véxase tamén

Bibliografía

• Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene 277 (1–2): 1–14. PMID 11602341. doi:10.1016/S0378-1119(01)00697-7.
• Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855. doi:10.1002/j.1460-2075.1989.tb03573.x.
• Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J (1988). "Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing". Mol. Cell. Biol. 8 (1): 186–95. PMC 363100. PMID 2827002. doi:10.1128/mcb.8.1.186.
• De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J (1988). "The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs". Mol. Cell. Biol. 8 (10): 4381–8. PMC 365511. PMID 3054516. doi:10.1128/mcb.8.10.4381.
• DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW (1988). "The human myc gene family: structure and activity of L-myc and an L-myc pseudogene". Genes Dev. 1 (10): 1311–1326. PMID 3322939. doi:10.1101/gad.1.10.1311.
• Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10217–10221. Bibcode:1995PNAS...9210217A. PMC 40767. PMID 7479755. doi:10.1073/pnas.92.22.10217.
• FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–2498. PMID 10229200. doi:10.1038/sj.onc.1202611.
• Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K (2002). "L-myc genotype is associated with different susceptibility to lung cancer in smokers". Jpn. J. Cancer Res. 93 (1): 1–5. PMC 5926866. PMID 11802801. doi:10.1111/j.1349-7006.2002.tb01193.x.
• Suzuki H, Yamashiro K (2002). "L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma". Oncol. Rep. 9 (2): 345–7. PMID 11836605. doi:10.3892/or.9.2.345.
• Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF (2002). "Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ". Oncol. Rep. 9 (3): 551–5. PMID 11956626. doi:10.3892/or.9.3.551.
• Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA (2003). "MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis". J. Cell. Mol. Med. 6 (2): 215–222. PMC 6740283. PMID 12169206. doi:10.1111/j.1582-4934.2002.tb00188.x.
• Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR (2003). "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603–10. PMC 1851191. PMID 12707044. doi:10.1016/S0002-9440(10)64294-0.
• Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N (2004). "Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer". Clin. Cancer Res. 10 (5): 1758–1763. PMID 15014029. doi:10.1158/1078-0432.CCR-0779-3.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209.
• Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer 55 (3): 271–277. PMID 17145094. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016.

Ligazóns externas

• MYCL1 protein, human Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA.

Este artigo incorpora textos da Biblioteca Nacional de Medicina dos Estados Unidos, que están en dominio público.

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