La proteína de unión a CREB, también conocido como CREBBP o CBP es una proteína codificada en humanos por el gen CREBBP.[1][2]
Datos rápidos Proteína de unión a CREB, Estructuras disponibles ...
Proteína de unión a CREB |
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Estructuras disponibles |
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PDB |
Buscar ortólogos: PDBe, RCSB PDBe, RCSB
Lista de códigos PDB 1JSP , 1LIQ , 1RDT , 1WO3 , 1WO4 , 1WO5 , 1WO6 , 1WO7 , 2D82 , 2KJE , 2KWF , 2L84 , 2L85 , 2LXS , 2LXT , 2RNY , 3DWY , 3P1C , 3P1D , 3P1E , 3P1F , 3SVH , 4A9K
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Identificadores |
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Símbolos |
CREBBP (HGNC: 2348) CBP; RSTS; RTS |
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Identificadores externos |
Bases de datos de enzimas
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Número EC |
2.3.1.48 |
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Locus |
Cr. 16 p13.3 |
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Patrón de expresión de ARNm |
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Más información |
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Especies |
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Entrez |
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Ensembl |
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UniProt |
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RefSeq (ARNm) |
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RefSeq (proteína) NCBI |
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Ubicación (UCSC) |
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PubMed (Búsqueda) |
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Cerrar
Este gen esta ubicuamente y está implicado en la co-activación transcripcional de diversos factores de transcripción. El primero fue aislado como una proteína nuclear que se une a proteínas de unión a elementos de respuesta a AMPc (CREB). Este gen es conocido por jugar un papel crítico en el desarrollo embrionario, el control de la proliferación celular y la homeostasis por medio de la reorganización de la cromatina para el reconocimiento de los factores de transcripción. Esta proteína posee una actividad histona acetiltransferasa intrínseca y actúa a su vez como andamio para estabilizar interacciones de proteínas adicionales con el complejo transcripcional. Esta proteína acetila tanto a histonas como a proteínas no histonas. Las CREBBP comparten regiones de una elevada similitud de secuencia con el bromodominio, las regiones ricas en cisteína-histidina y el dominio histona acetiltransferasa de la proteína EP300.[3]
Mutaciones en este gen son las causantes del síndrome de Rubinstein-Taybi (RTS).[4]
Se han asociado diversas traslocaciones cromosómicas de este gen con la leucemia mieloide aguda.[3][5]
La proteína CREBBP ha demostrado ser capaz de interaccionar con:
Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH (octubre de 1993). «Phosphorylated CREB binds specifically to the nuclear protein CBP». Nature 365 (6449): 855-9. PMID 8413673. doi:10.1038/365855a0.
Wydner KL, Bhattacharya S, Eckner R, Lawrence JB, Livingston DM (noviembre de 1995). «Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization». Genomics 30 (2): 395-6. PMID 8586450.
Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ (julio de 1995). «Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP». Nature 376 (6538): 348-51. PMID 7630403. doi:10.1038/376348a0.
Vizmanos JL, Larráyoz MJ, Lahortiga I, Floristán F, Alvarez C, Odero MD, Novo FJ, Calasanz MJ (abril de 2003). «t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia». Genes Chromosomes Cancer 36 (4): 402-5. PMID 12619164. doi:10.1002/gcc.10174.
Kim, J; Jia L, Stallcup M R, Coetzee G A (Feb. de 2005). «The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus». J. Mol. Endocrinol. (England) 34 (1): 107-18. ISSN 0952-5041. PMID 15691881. doi:10.1677/jme.1.01701.
Frønsdal, K; Engedal N; Slagsvold T; Saatcioglu F (Nov. de 1998). «CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1». J. Biol. Chem. (UNITED STATES) 273 (48): 31853-9. ISSN 0021-9258. PMID 9822653. doi:10.1074/jbc.273.48.31853.
Ishitani, Ken; Yoshida Tasuku, Kitagawa Hirochika, Ohta Hiroaki, Nozawa Shiro, Kato Shigeaki (Jul. de 2003). «p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor». Biochem. Biophys. Res. Commun. (United States) 306 (3): 660-5. ISSN 0006-291X. PMID 12810069. doi:10.1016/S0006-291X(03)01021-0.
Pitkänen, J; Doucas V, Sternsdorf T, Nakajima T, Aratani S, Jensen K, Will H, Vähämurto P, Ollila J, Vihinen M, Scott H S, Antonarakis S E, Kudoh J, Shimizu N, Krohn K, Peterson P (Jun. de 2000). «The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein». J. Biol. Chem. (UNITED STATES) 275 (22): 16802-9. ISSN 0021-9258. PMID 10748110. doi:10.1074/jbc.M908944199.
Iioka, Takashi; Furukawa Keizo, Yamaguchi Akira, Shindo Hiroyuki, Yamashita Shunichi, Tsukazaki Tomoo (Aug. de 2003). «P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain». J. Bone Miner. Res. (United States) 18 (8): 1419-29. ISSN 0884-0431. PMID 12929931. doi:10.1359/jbmr.2003.18.8.1419.
Fan, Saijun; Ma Yong Xian, Wang Chenguang, Yuan Ren-Qi, Meng Qinghui, Wang Ji-An, Erdos Michael, Goldberg Itzhak D, Webb Paul, Kushner Peter J, Pestell Richard G, Rosen Eliot M (Jan. de 2002). «p300 Modulates the BRCA1 inhibition of estrogen receptor activity». Cancer Res. (United States) 62 (1): 141-51. ISSN 0008-5472. PMID 11782371.
Chai, Y L; Cui J, Shao N, Shyam E, Reddy P, Rao V N (Jan. de 1999). «The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter». Oncogene (ENGLAND) 18 (1): 263-8. ISSN 0950-9232. PMID 9926942. doi:10.1038/sj.onc.1202323.
Benezra, Miriam; Chevallier Nathalie, Morrison Debra J, MacLachlan Timothy K, El-Deiry Wafik S, Licht Jonathan D (Jul. de 2003). «BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit». J. Biol. Chem. (United States) 278 (29): 26333-41. ISSN 0021-9258. PMID 12700228. doi:10.1074/jbc.M303076200.
Kawabuchi, M; Satomi Y; Takao T; Shimonishi Y; Nada S; Nagai K; Tarakhovsky A; Okada M (Apr. de 2000). «Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases». Nature (ENGLAND) 404 (6781): 999-1003. ISSN 0028-0836. PMID 10801129. doi:10.1038/35010121.
Kovacs KA, Steinmann M; Magistretti PJ; Halfon O; Cardinaux JR (Sept. de 2003). «CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation». J Biol. Chem. (UNITED STATES) 278 (38): 36959-65. ISSN 0021-9258. PMID 12857754. doi:10.1074/jbc.M303147200.
Lorentz, O; Suh E R, Taylor J K, Boudreau F, Traber P G (Mar. de 1999). «CREB-binding [corrected] protein interacts with the homeodomain protein Cdx2 and enhances transcriptional activity». J. Biol. Chem. (UNITED STATES) 274 (11): 7196-9. ISSN 0021-9258. PMID 10066780. doi:10.1074/jbc.274.11.7196.
Shimomura, A; Ogawa Y; Kitani T; Fujisawa H; Hagiwara M (Jul. de 1996). «Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein». J. Biol. Chem. (UNITED STATES) 271 (30): 17957-60. ISSN 0021-9258. PMID 8663317. doi:10.1074/jbc.271.30.17957.
Radhakrishnan, I; Pérez-Alvarado G C, Parker D, Dyson H J, Montminy M R, Wright P E (Dec. de 1997). «Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions». Cell (UNITED STATES) 91 (6): 741-52. ISSN 0092-8674. PMID 9413984. doi:10.1016/S0092-8674(00)80463-8.
Zor, Tsaffrir; Mayr Bernhard M, Dyson H Jane, Montminy Marc R, Wright Peter E (Nov. de 2002). «Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators». J. Biol. Chem. (United States) 277 (44): 42241-8. ISSN 0021-9258. PMID 12196545. doi:10.1074/jbc.M207361200.
Chakraborty, S; Senyuk V; Sitailo S; Chi Y; Nucifora G (Nov. de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. (United States) 276 (48): 44936-43. ISSN 0021-9258. PMID 11568182. doi:10.1074/jbc.M106733200.
Dai, P; Akimaru H; Tanaka Y; Maekawa T; Nakafuku M; Ishii S (Mar. de 1999). «Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3». J. Biol. Chem. (UNITED STATES) 274 (12): 8143-52. ISSN 0021-9258. PMID 10075717. doi:10.1074/jbc.274.12.8143.
Almlöf, T; Wallberg A E, Gustafsson J A, Wright A P (Jun. de 1998). «Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors». Biochemistry (UNITED STATES) 37 (26): 9586-94. ISSN 0006-2960. PMID 9649342. doi:10.1021/bi973029x.
Yoshida, E; Aratani S; Itou H; Miyagishi M; Takiguchi M; Osumu T; Murakami K; Fukamizu A (Dec. de 1997). «Functional association between CBP and HNF4 in trans-activation». Biochem. Biophys. Res. Commun. (UNITED STATES) 241 (3): 664-9. ISSN 0006-291X. PMID 9434765. doi:10.1006/bbrc.1997.7871.
Dell, H; Hadzopoulou-Cladaras M (Mar. de 1999). «CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression». J. Biol. Chem. (UNITED STATES) 274 (13): 9013-21. ISSN 0021-9258. PMID 10085149. doi:10.1074/jbc.274.13.9013.
Park, Young-Kwon; Ahn Dae-Ro, Oh Myoungsuk, Lee Taekyoung, Yang Eun Gyeong, Son Miwon, Park Hyunsung (Jul. de 2008). «Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation». Mol. Pharmacol. (United States) 74 (1): 236-45. PMID 18426857. doi:10.1124/mol.108.045278.
Hofmann, Thomas G; Möller Andreas, Sirma Hüaeyin, Zentgraf Hanswalter, Taya Yoichi, Dröge Wulf, Will Hans, Schmitz M Lienhard (Jan. de 2002). «Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2». Nat. Cell Biol. (England) 4 (1): 1-10. ISSN 1465-7392. PMID 11740489. doi:10.1038/ncb715.
Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (Apr. de 2000). «Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins». J. Biol. Chem. (UNITED STATES) 275 (17): 12515-20. ISSN 0021-9258. PMID 10777539. doi:10.1074/jbc.275.17.12515.
Chariot, A; van Lint C, Chapelier M, Gielen J, Merville M P, Bours V (Jul. de 1999). «CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein». Oncogene (ENGLAND) 18 (27): 4007-14. ISSN 0950-9232. PMID 10435624. doi:10.1038/sj.onc.1202776.
Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug. de 2002). «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. (United States) 277 (33): 29832-9. ISSN 0021-9258. PMID 12015309. doi:10.1074/jbc.M200197200.
Hong, Wei; Resnick Ross J, Rakowski Carrie, Shalloway David, Taylor Steven J, Blobel Gerd A (Nov. de 2002). «Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68». Mol. Cancer Res. (United States) 1 (1): 48-55. ISSN 1541-7786. PMID 12496368.
Chen, Qin; Dowhan Dennis H, Liang Dongcai, Moore David D, Overbeek Paul A (Jul. de 2002). «CREB-binding protein/p300 co-activation of crystallin gene expression». J. Biol. Chem. (United States) 277 (27): 24081-9. ISSN 0021-9258. PMID 11943779. doi:10.1074/jbc.M201821200.
Goto, Natalie K; Zor Tsaffrir, Martinez-Yamout Maria, Dyson H Jane, Wright Peter E (Nov. de 2002). «Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain». J. Biol. Chem. (United States) 277 (45): 43168-74. ISSN 0021-9258. PMID 12205094. doi:10.1074/jbc.M207660200.
Pearson, K L; Hunter T; Janknecht R (Dec. de 1999). «Activation of Smad1-mediated transcription by p300/CBP». Biochim. Biophys. Acta (NETHERLANDS) 1489 (2-3): 354-64. ISSN 0006-3002. PMID 10673036.
Sun, Y; Nadal-Vicens M, Misono S, Lin M Z, Zubiaga A, Hua X, Fan G, Greenberg M E (Feb. de 2001). «Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms». Cell (United States) 104 (3): 365-76. ISSN 0092-8674. PMID 11239394. doi:10.1016/S0092-8674(01)00224-0.
Bessa, M; Saville M K, Watson R J (Jun. de 2001). «Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator». Oncogene (England) 20 (26): 3376-86. ISSN 0950-9232. PMID 11423988. doi:10.1038/sj.onc.1204439.
Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404. doi:10.1074/jbc.274.48.34283.
Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb. de 2001). «Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2». Mol. Endocrinol. (United States) 15 (2): 241-54. ISSN 0888-8809. PMID 11158331. doi:10.1210/me.15.2.241.
Hung, H L; Kim A Y, Hong W, Rakowski C, Blobel G A (Apr. de 2001). «Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation». J. Biol. Chem. (United States) 276 (14): 10715-21. ISSN 0021-9258. PMID 11154691. doi:10.1074/jbc.M007846200.
Katoh, Y; Itoh K; Yoshida E; Miyagishi M; Fukamizu A; Yamamoto M (Oct. de 2001). «Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription». Genes Cells (England) 6 (10): 857-68. ISSN 1356-9597. PMID 11683914. doi:10.1046/j.1365-2443.2001.00469.x.
Naltner, A; Wert S, Whitsett J A, Yan C (Dec. de 2000). «Temporal/spatial expression of nuclear receptor coactivators in the mouse lung». Am. J. Physiol. Lung Cell Mol. Physiol. (UNITED STATES) 279 (6): L1066-74. ISSN 1040-0605. PMID 11076796.
Livengood, Jill A; Scoggin Kirsten E S, Van Orden Karen, McBryant Steven J, Edayathumangalam Rajeswari S, Laybourn Paul J, Nyborg Jennifer K (Mar. de 2002). «p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300». J. Biol. Chem. (United States) 277 (11): 9054-61. ISSN 0021-9258. PMID 11782467. doi:10.1074/jbc.M108870200.
Tini, Marc; Benecke Arndt, Um Soo-Joong, Torchia Joseph, Evans Ronald M, Chambon Pierre (Feb. de 2002). «Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription». Mol. Cell (United States) 9 (2): 265-77. ISSN 1097-2765. PMID 11864601. doi:10.1016/S1097-2765(02)00453-7.
Matsuzaki, Kazuhito; Minami Takeshi, Tojo Masahide, Honda Yoshiomi, Saitoh Noriko, Nagahiro Shinji, Saya Hideyuki, Nakao Mitsuyoshi (Mar. de 2003). «PML-nuclear bodies are involved in cellular serum response». Genes Cells (England) 8 (3): 275-86. ISSN 1356-9597. PMID 12622724. doi:10.1046/j.1365-2443.2003.00632.x.
Zhong, S; Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P (Nov. de 1999). «A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins». Nat. Genet. (UNITED STATES) 23 (3): 287-95. ISSN 1061-4036. PMID 10610177. doi:10.1038/15463.
Jang, Hyun Duk; Yoon Kwiyeom, Shin Young Joo, Kim Jaesang, Lee Soo Young (Jun. de 2004). «PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit». J. Biol. Chem. (United States) 279 (23): 24873-80. ISSN 0021-9258. PMID 15140884. doi:10.1074/jbc.M313018200.
Parry, G C; Mackman N (Dec. de 1997). «Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription». J. Immunol. (UNITED STATES) 159 (11): 5450-6. ISSN 0022-1767. PMID 9548485.
Hirose, Takuji; Fujii Ryouji, Nakamura Hiroshi, Aratani Satoko, Fujita Hidetoshi, Nakazawa Minako, Nakamura Kohzo, Nishioka Kusuki, Nakajima Toshihiro (Jun. de 2003). «Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP». Int. J. Mol. Med. (Greece) 11 (6): 705-12. ISSN 1107-3756. PMID 12736710.
Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. de 1996). «SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein». Genes Dev. (UNITED STATES) 10 (22): 2903-11. ISSN 0890-9369. PMID 8918891. doi:10.1101/gad.10.22.2903.
Aizawa, Hiroyuki; Hu Shu-Ching, Bobb Kathryn, Balakrishnan Karthik, Ince Gulayse, Gurevich Inga, Cowan Mitra, Ghosh Anirvan (Jan. de 2004). «Dendrite development regulated by CREST, a calcium-regulated transcriptional activator». Science (United States) 303 (5655): 197-202. PMID 14716005. doi:10.1126/science.1089845.
Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M (Sep. de 1996). «Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha». Nature (ENGLAND) 383 (6598): 344-7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0.
Bradney, Curtis; Hjelmeland Mark, Komatsu Yasuhiko, Yoshida Minoru, Yao Tso-Pang, Zhuang Yuan (Jan. de 2003). «Regulation of E2A activities by histone acetyltransferases in B lymphocyte development». J. Biol. Chem. (United States) 278 (4): 2370-6. ISSN 0021-9258. PMID 12435739. doi:10.1074/jbc.M211464200.
Misra, Parimal; Qi Chao, Yu Songtao, Shah Sejal H, Cao Wen-Qing, Rao M Sambasiva, Thimmapaya Bayar, Zhu Yijun, Reddy Janardan K (mayo. de 2002). «Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation». J. Biol. Chem. (United States) 277 (22): 20011-9. ISSN 0021-9258. PMID 11912212. doi:10.1074/jbc.M201739200.
Gizard, F; Lavallée B, DeWitte F, Hum D W (Sep. de 2001). «A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression». J. Biol. Chem. (United States) 276 (36): 33881-92. ISSN 0021-9258. PMID 11349124. doi:10.1074/jbc.M100113200.