Prostaglandin E synthase

Prostaglandin E synthase (EC 5.3.99.3, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.^[2][3]

prostaglandin-E synthase
human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry 3DWW[1]
Identifiers
EC no.	5.3.99.3
CAS no.	52227-79-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The synthase generating PGE2 is a membrane-associated protein.

Biosynthesis of eicosanoids.

Isozymes

Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

prostaglandin E synthase (microsomal) Identifiers Symbol PTGES Alt. symbols MGST1L1 NCBI gene 9536 HGNC 9599 OMIM 605172 RefSeq NM_004878 UniProt O14684 Other data Locus Chr. 9 q34.3 Search for Structures Swiss-model Domains InterPro

prostaglandin E synthase 2 (microsomal) Identifiers Symbol PTGES2 Alt. symbols C9orf15 NCBI gene 80142 HGNC 17822 OMIM 608152 RefSeq NM_198939 UniProt Q9H7Z7 Other data Locus Chr. 9 q34.12 Search for Structures Swiss-model Domains InterPro

prostaglandin E synthase 3 (cytosolic) Identifiers Symbol PTGES3 Alt. symbols p23, TEBP, cPGES NCBI gene 10728 HGNC 16049 OMIM 607061 RefSeq NM_006601 UniProt Q15185 Other data Locus Chr. 12 q13.13 Search for Structures Swiss-model Domains InterPro

References

1. Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). "Structural basis for induced formation of the inflammatory mediator prostaglandin E2". Proceedings of the National Academy of Sciences. 105 (32): 11110–11115. Bibcode:2008PNAS..10511110J. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561.
2. Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). "Prostaglandin E synthase". Prostaglandins Other Lipid Mediat. 68–69: 383–99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931. S2CID 22246484.
3. Park JY, Pillinger MH, Abramson SB (June 2006). "Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases". Clin. Immunol. 119 (3): 229–40. doi:10.1016/j.clim.2006.01.016. PMID 16540375.

External links

• prostaglandin-E+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• EC 5.3.99.3