PTGES3

Prostaglandin E synthase 3 (cytosolic) is a Prostaglandin E synthase enzyme that in humans is encoded by the PTGES3 gene.^[5]

PTGES3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EJF
Identifiers
Aliases	PTGES3, P23, TEBP, cPGES, prostaglandin E synthase 3
External IDs	OMIM: 607061; MGI: 1929282; HomoloGene: 128197; GeneCards: PTGES3; OMA:PTGES3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3|12 Start 56,663,341 bp[1] End 56,688,408 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,894,823 bp[2] End 127,913,141 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell gonad mucosa of sigmoid colon caput epididymis ventricular zone embryo ganglionic eminence corpus epididymis trabecular bone Top expressed in abdominal wall medullary collecting duct renal corpuscle Gonadal ridge endocardial cushion cumulus cell primitive streak vas deferens migratory enteric neural crest cell epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function unfolded protein binding telomerase activity isomerase activity protein binding prostaglandin-E synthase activity Hsp90 protein binding DNA polymerase binding chaperone binding Cellular component nucleoplasm telomere telomerase holoenzyme complex extracellular exosome nucleus cytoplasm cytosol protein-containing complex chaperone complex Biological process prostaglandin metabolic process lipid metabolism cyclooxygenase pathway fatty acid metabolic process fatty acid biosynthetic process regulation of cellular response to heat prostaglandin biosynthetic process telomere maintenance signal transduction xenobiotic metabolic process telomere maintenance via telomerase positive regulation of phosphorylation positive regulation of telomerase activity telomerase holoenzyme complex assembly protein stabilization chaperone-mediated protein complex assembly protein folding chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10728 56351 Ensembl ENSG00000110958 ENSMUSG00000071072 UniProt Q15185 Q9R0Q7 RefSeq (mRNA) NM_001282601 NM_001282602 NM_001282603 NM_001282604 NM_001282605 NM_006601 NM_019766 RefSeq (protein) NP_001269530 NP_001269531 NP_001269532 NP_001269533 NP_001269534 NP_006592 NP_062740 Location (UCSC) Chr 12: 56.66 – 56.69 Mb Chr 10: 127.89 – 127.91 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning of the glucocorticoid and other steroid receptors.^[6]