List of Schedule II controlled substances (U.S.)

This is the list of Schedule II controlled substances in the United States as defined by the Controlled Substances Act.^[1] The following findings are required for substances to be placed in this schedule:^[2]

1. The drug or other substance has a high potential for abuse.
2. The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.
3. Abuse of the drug or other substances may lead to severe psychological or physical dependence.

The complete list of Schedule II substances is as follows. The Administrative Controlled Substances Code Number and Federal Register citation for each substance is included.

Drugs

ACSCN	Class	Drug
9050	opiate	Codeine[3]
9334	opiate	Dihydroetorphine[4]
9190	opiate	Ethylmorphine[3]
9059	opiate	Etorphine hydrochloride[5]
9640	opiate	Granulated opium[3]
9193	opiate	Hydrocodone[3]
9150	opiate	Hydromorphone[3]
9260	opiate	Metopon[3]
9300	opiate	Morphine[3]
9668	opiate	Noroxymorphone[6]
9610	opiate	Opium extracts[3]
9620	opiate	Opium fluid[3]
9330	opiate	Oripavine[7]
9143	opiate	Oxycodone[3]
9652	opiate	Oxymorphone[3]
9639	opiate	Powdered opium[3]
9600	opiate	Raw opium[3]
9333	opiate	Thebaine[3]
9630	opiate	Tincture of opium[3]
	opiate	Opium poppy and poppy straw[8][note 1]
9040	stimulant	Coca, leaves and any salt, compound, derivative or preparation of coca leaves[8][note 1]
9041	stimulant	Cocaine, and its salts, isomers, derivatives and salts of isomers and derivatives[8][note 1]
9180	stimulant	Ecgonine, and its salts, isomers, derivatives and salts of isomers and derivatives[8][note 1]
9670	opiate	Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy)[9]
9737	opiate	Alfentanil[10]
9010	opiate	Alphaprodine[8][note 1]
9020	opiate	Anileridine[8][note 1]
9800	opiate	Bezitramide[8][note 1]
9273	opiate	Bulk dextropropoxyphene (non-dosage forms)[11]
9743	opiate	Carfentanil[12]
9120	opiate	Dihydrocodeine[8][note 1]
9170	opiate	Diphenoxylate[8][note 1]
9801	opiate	Fentanyl[8][note 1]
9226	opiate	Isomethadone[8][note 1]
9648	opiate	Levo-alphacetylmethadol[13]
9210	opiate	Levomethorphan[8][note 1]
9220	opiate	Levorphanol[8][note 1]
9240	opiate	Metazocine[8][note 1]
9250	opiate	Methadone[8][note 1]
9254	opiate	Methadone intermediate[8][note 1]
9802	opiate	Moramide intermediate[8][note 1]
9245	opiate	Oliceridine[14]
9230	opiate	Pethidine (meperidine)[8][note 1]
9232	opiate	Pethidine intermediate A[8][note 1]
9233	opiate	Pethidine intermediate B[8][note 1]
9234	opiate	Pethidine intermediate C[8][note 1]
9715	opiate	Phenazocine[8][note 1]
9730	opiate	Piminodine[8][note 1]
9732	opiate	Racemethorphan[8][note 1]
9733	opiate	Racemorphan[8][note 1]
9739	opiate	Remifentanil[15]
9740	opiate	Sufentanil[16]
9780	opiate	Tapentadol[17]
9729	opiate	Thiafentanil[18]
1100	stimulant	Amphetamine, its salts, optical isomers, and salts of its optical isomers[19]
1105	stimulant	Methamphetamine, its salts, optical isomers, and salts of optical isomers[19]
1631	stimulant	Phenmetrazine and its salts [20]
1724	stimulant	Methylphenidate[20]
1205	stimulant	Lisdexamfetamine, its salts, isomers, and salts of its isomers[21]
2125	depressant	Amobarbital[22]
2550	depressant	Glutethimide[23]
2270	depressant	Pentobarbital[22]
7471	depressant	Phencyclidine[24]
2315	depressant	Secobarbital[22]
7379	hallucinogen	Nabilone[25]
7365	hallucinogen	Dronabinol oral solution[26]
8501	precursor	Phenylacetone[27]
7460	precursor	1-phenylcyclohexylamine[27]
8603	precursor	1-piperidinocyclohexanecarbonitrile (PCC)[27]
8333	precursor	4-anilino-N-phenethyl-4-piperidine (4-ANPP)[28]
8366	precursor	Norfentanyl[29]

See also

• List of Schedule I controlled substances (U.S.)
• List of Schedule III controlled substances (U.S.)
• List of Schedule IV controlled substances (U.S.)
• List of Schedule V controlled substances (U.S.)

Notes

1. This substance was expressly scheduled by the Controlled Substances Act on October 27, 1970. The 1974 Federal Register ruling (by Administrator John R. Bartels, Jr.) merely organized its listing in the Code of Federal Regulations.

References

1. "21 C.F.R. 1308.12 (Schedule II)". Code of Federal Regulations. Retrieved September 7, 2023.
2. 21 U.S.C. § 812(b)(4) retrieved October 7, 2007
3. Ingersoll, John (September 29, 1971). "Schedules of Controlled Substances: Removal of Naloxone From Control" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived from the original (PDF) on September 16, 2021. Retrieved September 7, 2023.
4. Mercado, Julio (November 17, 2000). "Schedule II Control of Dihydroetorphine Under the Controlled Substances Act". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
5. Bartels, Jr., John R. (March 29, 1974). "Etorphine Hydrochloride Transfer to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on September 26, 2021. Retrieved September 7, 2023.
6. Dhillon, Uttam (August 16, 2019). "Listing of Noroxymorphone in the Code of Federal Regulations and Assignment of a Controlled Substances Code Number". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
7. Leonhart, Michele (September 24, 2007). "Designation of Oripavine as a Basic Class of Controlled Substance". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
8. Bartels Jr., John R. (June 20, 1974). "PART 1308— SCHEDULES OF CONTROLLED SUBSTANCES: Annual Publication" (PDF). Government Publishing Office. Drug Enforcement Administration. Archived from the original (PDF) on September 6, 2023. Retrieved September 6, 2023.
9. Bartels, Jr., John R. (February 14, 1975). "Concentrate of Poppy Straw, Addition to Schedule II and Authorizing its Importation" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on September 26, 2021. Retrieved September 7, 2023.
10. Lawn, John (January 23, 1987). "Rescheduling of Alfentanil from Schedule I to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on July 28, 2019. Retrieved September 7, 2023.
11. Bensinger, Peter (July 22, 1980). "Control of Bulk Dextropropoxyphene (Non-dosage Forms) in Schedule II as an Opiate" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 24, 2016. Retrieved September 7, 2023.
12. Lawn, John (October 28, 1988). "Placement of Carfentanil into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on March 22, 2016. Retrieved September 7, 2023.
13. Bonner, Robert (August 18, 1993). "Schedules of Controlled Substances; Transfer of Levo-acetylmethadol from Schedule I into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived from the original (PDF) on July 28, 2019. Retrieved January 16, 2023.
14. Evans, D. Christopher (July 12, 2021). "Schedules of Controlled Substances: Placement of Oliceridine in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
15. Milford, Jr., James S. (November 5, 1996). "Schedules of Controlled Substances: Placement of Remifentanil Into Schedule II". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
16. Mullen, Jr., Francis M. (May 25, 1984). "Schedules of Controlled Substances; Rescheduling of Sufentanil into Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on May 19, 2019. Retrieved January 16, 2023.
17. Leonhart, Michele (May 21, 2009). "Schedules of Controlled Substances: Placement of Tapentadol Into Schedule II". Federal Register. Drug Enforcement Administration. Retrieved January 16, 2023.
18. Dhillon, Uttam (June 10, 2019). "Schedules of Controlled Substances: Placement of Thiafentanil in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
19. Ingersoll, John (July 7, 1971). "Amphetamine, Methamphetamine, and Optical Isomers" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
20. Finlator, John (October 28, 1971). "Phenmetrazine and its salts, and Methylphenidate" (PDF). Isomer Design. Bureau of Narcotics and Dangerous Drugs. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
21. Leonhart, Michele (May 3, 2007). "Schedules of Controlled Substances: Placement of Lisdexamfetamine Into Schedule II". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
22. Bartels, Jr., John R. (November 13, 1973). "Schedule II Control of Amobarbital, Pentobarbital, Secobarbital, and their salts" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
23. Bonner, Robert (March 21, 1991). "Schedules of Controlled Substances: Transfer of Glutethimide from Schedule III to Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
24. Bensinger, Peter (January 25, 1978). "Placement of Phencyclidine in Schedule II" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
25. Lawn, John (April 7, 1987). "Placement of Nabilone in Schedule II" (PDF). Government Publishing Office. Drug Enforcement Administration. p. 11042. Archived from the original (PDF) on April 30, 2023. Retrieved September 7, 2023.
26. Patterson, Robert (November 22, 2017). "Schedules of Controlled Substances: Placement of FDA-Approved Products of Oral Solutions Containing Dronabinol [(-)-delta-9-trans-tetrahydrocannabinol (delta-9-THC)] in Schedule II". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.
27. Bensinger, Peter (February 11, 1980). "Schedules of Controlled Substances; Schedule II Placement of Phenylacetone; (Phenyl-2-propanone, P2P, methyl benzyl ketone, benzyl methyl ketone)" (PDF). Isomer Design. Drug Enforcement Administration. Archived (PDF) from the original on March 3, 2022. Retrieved January 16, 2023.
28. Leonhart, Michele (June 29, 2010). "Control of Immediate Precursor Used in the Illicit Manufacture of Fentanyl as a Schedule II Controlled Substance". Federal Register. Drug Enforcement Administration. Archived from the original on January 16, 2023. Retrieved January 16, 2023.
29. Dhillon, Uttam (April 17, 2020). "Control of the Immediate Precursor Norfentanyl Used in the Illicit Manufacture of Fentanyl as a Schedule II Controlled Substance". Federal Register. Drug Enforcement Administration. Retrieved September 7, 2023.