Actinomycetales

The Actinomycetales is an order of Actinomycetota. A member of the order is often called an actinomycete. Actinomycetales are generally gram-positive and anaerobic and have mycelia in a filamentous and branching growth pattern. Some actinomycetes can form rod- or coccoid-shaped forms, while others can form spores on aerial hyphae. Actinomycetales bacteria can be infected by bacteriophages, which are called actinophages. Actinomycetales can range from harmless bacteria to pathogens with resistance to antibiotics.

Actinomycetales
Scanning electron micrograph of Actinomyces israelii.
Scientific classification
Domain:	Bacteria
Phylum:	Actinomycetota
Class:	Actinomycetia
Order:	Actinomycetales Buchanan 1917 (Approved Lists 1980)[1]
Type genus
Actinomyces Harz 1877 (Approved Lists 1980)
Families[2]
Actinomycetaceae
Synonyms
"Actinobacteriales" Prévot 1946 Actinomycetineae Stackebrandt, Rainey & Ward-Rainey 1997

Reproduction

Actinomycetales have 2 main forms of reproduction: spore formation and hyphae fragmentation. During reproduction, Actinomycetales can form conidiophores, sporangiospores, and oidiospores. In reproducing through hyphae fragmentation, the hyphae formed by Actinomycetales can be a fifth to half the size of fungal hyphae, and bear long spore chains.

Presence and associations

Actinomycetales can be found mostly in soil and decaying organic matter, as well as in living organisms such as humans and animals. They form symbiotic nitrogen fixing associations with over 200 species of plants, and can also serve as growth promoting or biocontrol agents, or cause disease in some species of plants. Actinomycetales can be found in the human urogenital tract as well as in the digestive system including the mouth, throat, and gastrointestinal tract in the form of Helicobacter without causing disease in the host. They also have wide medicinal and botanical applications, and are used as a source of many antibiotics and pesticides.

Antimicrobial properties

Many species of Actinomycetes produce antimicrobial compounds under certain conditions and growth media. Streptomycin, actinomycin, and streptothricin are all medically important antibiotics isolated from Actinomycetes bacteria.^[3] Almost two-thirds of the natural antimicrobial drug compounds used currently are produced by different species of Actinomycetes.^[4]

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)^[2] and National Center for Biotechnology Information (NCBI)^[5]

Whole-genome based phylogeny[6]	16S rRNA based LTP_08_2023[7][8][9]	120 marker proteins based GTDB 08-RS214[10][11][12]
Microbacteriales "Tropherymataceae" Microbacteriaceae Kineosporiales "Quadrisphaeraceae" [incl. "Kineococcaceae"] Kineosporiaceae Kytococcaceae Ornithinimicrobiaceae Dermatophilaceae Dermacoccaceae Intrasporangiaceae Bifidobacteriales Bifidobacteriaceae Actinomycetales Actinomycetaceae Cellulomonadales Demequinaceae Beutenbergiaceae Bogoriellaceae Ruaniaceae Cellulomonadaceae Jonesiaceae Promicromonosporaceae Micrococcales Dermabacteraceae Brevibacteriaceae Micrococcaceae	Kineosporiales Kineosporiaceae [incl. "Kineococcaceae"; "Quadrisphaeraceae"] Aquipuribacterales Aquipuribacteraceae Georgenia Promicromonosporaceae Actinomycetales Beutenbergiaceae Bogoriellaceae Ruaniaceae Actinomycetaceae [incl. Arcanobacteriaceae] Micrococcales "Angustibacteraceae" Actinotaleaceae Jonesiaceae [incl. Rarobacteraceae; Sanguibacteraceae] Oerskoviaceae Cellulomonadaceae Dermatophilaceae [incl. Arsenicicoccaceae] Dermacoccaceae Kytococcaceae Ornithinimicrobiaceae Intrasporangiaceae Demequinaceae Dermabacteraceae Micrococcaceae [incl. Yaniellaceae] Brevibacteriaceae Bifidobacteriaceae Microbacteriaceae [incl. Tropherymataceae]	Actinomycetales Kineosporiineae Kineosporiaceae "Kineococcaceae" "Quadrisphaeraceae" "Angustibacteraceae" Dermatophilaceae [incl. Aquipuribacteraceae; Arsenicicoccaceae; Dermacoccaceae; Kytococcaceae; Ornithinimicrobiaceae; Intrasporangiaceae] Actinomycetineae Demequinaceae Cellulomonadaceae [incl. Actinotaleaceae; Jonesiaceae; Oerskoviaceae; Promicromonosporaceae; Rarobacteraceae; Sanguibacteraceae] Beutenbergiaceae [incl. Ruaniaceae] Actinomycetaceae [incl. Arcanobacteriaceae; Bogoriellaceae] Micrococcineae Dermabacteraceae Brevibacteriaceae Micrococcaceae [incl. Yaniellaceae] Bifidobacteriaceae Microbacteriaceae [incl. Tropherymataceae]

See also

• Bacterial taxonomy
• List of bacterial orders
• List of bacteria genera

References

1. Buchanan RE (1917). "Studies in the Nomenclature and Classification of the Bacteria: II. The Primary Subdivisions of the Schizomycetes". J Bacteriol. 2: 155–164. doi:10.1128/jb.2.2.155-164.1917. PMC 378699. PMID 16558735.
2. A.C. Parte; et al. "Actinomycetales". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2023-09-09.
3. Waksman, Selman A.; Schatz, Albert; Reynolds, Donald M. (December 2010). "Production of antibiotic substances by Actinomycetes". Annals of the New York Academy of Sciences. 1213 (1): 112–124. doi:10.1111/j.1749-6632.2010.05861.x. PMID 21175680.
4. Bentley, S. D.; Chater, K. F.; Cerdeño-Tárraga, A.-M.; Challis, G. L.; Thomson, N. R.; James, K. D.; Harris, D. E.; Quail, M. A.; Kieser, H.; Harper, D.; Bateman, A.; Brown, S.; Chandra, G.; Chen, C. W.; Collins, M.; Cronin, A.; Fraser, A.; Goble, A.; Hidalgo, J.; Hornsby, T.; Howarth, S.; Huang, C.-H.; Kieser, T.; Larke, L.; Murphy, L.; Oliver, K.; O'Neil, S.; Rabbinowitsch, E.; Rajandream, M.-A.; Rutherford, K.; Rutter, S.; Seeger, K.; Saunders, D.; Sharp, S.; Squares, R.; Squares, S.; Taylor, K.; Warren, T.; Wietzorrek, A.; Woodward, J.; Barrell, B. G.; Parkhill, J.; Hopwood, D. A. (9 May 2002). "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)". Nature. 417 (6885): 141–147. doi:10.1038/417141a. PMID 12000953.
5. Sayers; et al. "Actinomycetales". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2023-09-09.
6. Nouioui I, Carro L, García-López M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Markus Göker M (2018). "Genome-Based Taxonomic Classification of the Phylum Actinobacteria". Front. Microbiol. 9: 2007. doi:10.3389/fmicb.2018.02007. PMC 6113628. PMID 30186281.
7. "The LTP". Retrieved 20 November 2023.
8. "LTP_all tree in newick format". Retrieved 20 November 2023.
9. "LTP_08_2023 Release Notes" (PDF). Retrieved 20 November 2023.
10. "GTDB release 08-RS214". Genome Taxonomy Database. Retrieved 10 May 2023.
11. "bac120_r214.sp_label". Genome Taxonomy Database. Retrieved 10 May 2023.
12. "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2023.