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From Wikipedia, the free encyclopedia
Streptothricins are a group of antibiotics in the aminoglycoside class.[1] The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942.[2] It was later determined to be a mixture of closely-related compounds, and is now known as nourseothricin. Although initial interest was positive because it appeared to be the first broad-spectrum antibiotic, meaning it was effective against both Gram-positive and Gram-negative bacteria, it never found clinical use due to toxicity.[3] However, because of the increasing need for new antibiotics due to resistance to existing antibiotics, there is a current interest in developing new drugs based on the chemical scaffold of the streptothricins.[1][4][5]
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