ZNF8

Protein 8 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF8.^[5][6]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MAAARPEAQS		RSSPTPESRS		QEPLDLVLVP		DDCRPGTPPS		DLIEIQVVKV
TDTTLVPEPP		EPGSFHCALC		PAAFRLVSEL		LFHEHGHLAG		AEGGGQGGDP
SRCHVCGHSC		PGPASLRAHY		SLHTGERPYR		CALCPRAFKA		LAPLLRHQHR
HGVEPGTSRR		PPDTAAVAEQ		RPGVAPERAE		VVMAAAAAGA		AVGKPFACRF
CAKPFRRSSD		MRDHERVHTG		ERPYHCGICG		KGFTQSSVLS		GHARIHTGER
PFRCTLCDRT		FNNSSNFRKH		QRTHFHGPGP		GLGDSGGQLG		SSAAEGSGSG
CGVGDPAEEG		RGETAKVKVE		ADQ

ZNF8
Identifikatori
Aliasi	ZNF8
Vanjski ID-jevi	OMIM: 194532 MGI: 2389445 HomoloGene: 10889 GeneCards: ZNF8
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek)[1] Bend 19q13.43 Početak 58,278,955 bp[1] Kraj 58,302,791 bp[1]
Lokacija gena (miš) Hrom. Hromosom 7 (miš)[2] Bend 7|7 A1 Početak 12,615,104 bp[2] Kraj 12,627,349 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona cinka • vezivanje iona metala • nucleic acid binding Ćelijska komponenta • intracellular anatomical structure • jedro Biološki proces • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • BMP signaling pathway • transcription, DNA-templated Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7554	243833
Ensembl	ENSG00000278129	ENSMUSG00000060397
UniProt	P17098	Q8BGV5
RefSeq (mRNK)	NM_021089	NM_153802
RefSeq (bjelančevina)	NP_066575	NP_722497
Lokacija (UCSC)	Chr 19: 58.28 – 58.3 Mb	Chr 7: 12.62 – 12.63 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.^[6]

Reference

1. GRCh38: Ensembl release 89: ENSG00000278129 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060397 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lania L, Donti E, Pannuti A, Pascucci A, Pengue G, Feliciello I, La Mantia G, Lanfrancone L, Pelicci PG (Apr 1990). "cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes". Genomics. 6 (2): 333–40. doi:10.1016/0888-7543(90)90574-E. PMID 2106481.
6. "Entrez Gene: ZNF8 zinc finger protein 8".

Dopunska literatura

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiao K, Zhou Y, Hogan BL (2002). "Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1". Mol. Cell. Biol. 22 (21): 7633–44. doi:10.1128/MCB.22.21.7633-7644.2002. PMC 135661. PMID 12370310.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi