ZNF438

Protein cinkovog prsta 438 jest protein koji je kod ljudi kodiran genom ZNF438.^[5]

ZNF438
Identifikatori
Aliasi	ZNF438
Vanjski ID-jevi	MGI: 2444919 HomoloGene: 18695 GeneCards: ZNF438
Lokacija gena (čovjek) Hrom. Hromosom 10 (čovjek)[1] Bend 10p11.23 Početak 30,820,207 bp[1] Kraj 31,031,937 bp[1]
Lokacija gena (miš) Hrom. Hromosom 18 (miš)[2] Bend 18|18 A1 Početak 5,210,029 bp[2] Kraj 5,334,807 bp[2]
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • sequence-specific DNA binding Ćelijska komponenta • jedro • nukleoplazma • citosol Biološki proces • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	220929	240186
Ensembl	ENSG00000183621	ENSMUSG00000050945
UniProt	Q7Z4V0	n/a
RefSeq (mRNK)	NM_001143766 NM_001143767 NM_001143768 NM_001143769 NM_001143770 NM_001143771 NM_182755 NM_001387405 NM_001387411 NM_001387412	NM_178722 NM_001360447
RefSeq (bjelančevina)	NP_001137238 NP_001137239 NP_001137240 NP_001137241 NP_001137242 NP_001137243 NP_877432	n/a
Lokacija (UCSC)	Chr 10: 30.82 – 31.03 Mb	Chr 18: 5.21 – 5.33 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 828 aminokiselina, a molekulska težina 91.836.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MQNSVSVPPK		DEGESNIPSG		TIQSRKGLQN		KSQFRTIAPK		IVPKVLTSRM
LPCHSPSRSD		QVNLGPSINS		KLLGMSTQNY		ALMQVAGQEG		TFSLVALPHV
ASAQPIQKPR		MSLPENLKLP		IPRYQPPRNS		KASRKKPILI		FPKSGCSKAP
AQTQMCPQMS		PSPPHHPELL		YKPSPFEEVP		SLEQAPASIS		TAALTNGSDH
GDLRPPVTNT		HGSLNPPATP		ASSTPEEPAK		QDLTALSGKA		HFVSKITSSK
PSAVASEKFK		EQVDLAKTMT		NLSPTILGNA		VQLISSVPKG		KLPIPPYSRM
KTMEVYKIKS		DANIAGFSLP		GPKADCDKIP		STTEGFNAAT		KVASRLPVPQ
VSQQSACESA		FCPPTKLDLN		HKTKLNSGAA		KRKGRKRKVP		DEILAFQGKR
RKYIINKCRD		GKERVKNDPQ		EFRDQKLGTL		KKYRSIMPKP		IMVIPTLASL
ASPTTLQSQM		LGGLGQDVLL		NNSLTPKYLG		CKQDNSSSPK		PSSVFRNGFS
GIKKPWHRCH		VCNHHFQFKQ		HLRDHMNTHT		NRRPYSCRIC		RKSYVRPGSL
STHMKLHHGE		NRLKKLMCCE		FCAKVFGHIR		VYFGHLKEVH		RVVISTEPAP
SELQPGDIPK		NRDMSVRGME		GSLERENKSN		LEEDFLLNQA		DEVKLQIKCG
RCQITAQSFA		EIKFHLLDVH		GEEIEGRLQE		GTFPGSKGTQ		EELVQHASPD
WKRHPERGKP		EKVHSSSEES		HACPRLKRQL		HLHQNGVEML		MENEGPQSGT
NKPRETCQGP		ECPGLHTFLL		WSHSGFNCLL		CAEMLGRKED		LLHHWKHQHN
CEDPSKLWAI		LNTVSNQGVI		ELSSEAEK

Reference

1. GRCh38: Ensembl release 89: ENSG00000183621 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050945 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 438". Pristupljeno 26. 5. 2016.
6. "UniProt, Q7Z4V0". Pristupljeno 31. 8. 2021.

Dopunska literatura

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.