ZNF236

Cinkoprstni protein 236 je protein koji je kod ljudi kodiran genom ZNF236.^[5]

ZNF236
Identifikatori
Aliasi	ZNF236
Vanjski ID-jevi	OMIM: 604760 MGI: 1926950 HomoloGene: 7198 GeneCards: ZNF236
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek)[1] Bend 18q23 Početak 76,822,557 bp[1] Kraj 76,972,901 bp[1]
Lokacija gena (miš) Hrom. Hromosom 18 (miš)[2] Bend 18 E3|18 56.26 cM Početak 82,611,718 bp[2] Kraj 82,711,008 bp[2]
Ontologija gena Molekularna funkcija • vezivanje sa DNK • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Ćelijska komponenta • jedro Biološki proces • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • cellular response to glucose stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	7776	329002
Ensembl	ENSG00000130856	ENSMUSG00000041258
UniProt	Q9UL36	n/a
RefSeq (mRNK)	NM_001306089 NM_007345	NM_177832 NM_001374229
RefSeq (bjelančevina)	NP_001293018 NP_031371	n/a
Lokacija (UCSC)	Chr 18: 76.82 – 76.97 Mb	Chr 18: 82.61 – 82.71 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Dužina polipeptidnog lanca je 1.845 aminokiselina, sa molekulskom težinom od 203.704.^[6].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGLCGLLERC		WLHHDPDGVL		TLNAENTNYA		YQVPNFHKCE		ICLLSFPKES
QFQRHMRDHE		RNDKPHRCDQ		CPQTFNVEFN		LTLHKCTHSG		EDPTCPVCNK
KFSRVASLKA		HIMLHEKEEN		LICSECGDEF		TLQSQLAVHM		EEHRQELAGT
RQHACKACKK		EFETSSELKE		HMKTHYKIRV		SSTRSYNRNI		DRSGFTYSCP
HCGKTFQKPS		QLTRHIRIHT		GERPFKCSEC		GKAFNQKGAL		QTHMIKHTGE
KPHACAFCPA		AFSQKGNLQS		HVQRVHSEVK		NGPTYNCTEC		SCVFKSLGSL
NTHISKMHMG		GPQNSTSSTE		TAHVLTATLF		QTLPLQQTEA		QATSASSQPS
SQAVSDVIQQ		LLELSEPAPV		ESGQSPQPGQ		QLSITVGINQ		DILQQALENS
GLSSIPAAAH		PNDSCHAKTS		APHAQNPDVS		SVSNEQTDPT		DAEQEKEQES
PEKLDKKEKK		MIKKKSPFLP		GSIREENGVR		WHVCPYCAKE		FRKPSDLVRH
IRIHTHEKPF		KCPQCFRAFA		VKSTLTAHIK		THTGIKAFKC		QYCMKSFSTS
GSLKVHIRLH		TGVRPFACPH		CDKKFRTSGH		RKTHIASHFK		HTELRKMRHQ
RKPAKVRVGK		TNIPVPDIPL		QEPILITDLG		LIQPIPKNQF		FQSYFNNNFV
NEADRPYKCF		YCHRAYKKSC		HLKQHIRSHT		GEKPFKCSQC		GRGFVSAGVL
KAHIRTHTGL		KSFKCLICNG		AFTTGGSLRR		HMGIHNDLRP		YMCPYCQKTF
KTSLNCKKHM		KTHRYELAQQ		LQQHQQAASI		DDSTVDQQSM		QASTQMQVEI
ESDELPQTAE		VVAANPEAML		DLEPQHVVGT		EEAGLGQQLA		DQPLEADEDG
FVAPQDPLRG		HVDQFEEQSP		AQQSFEPAGL		PQGFTVTDTY		HQQPQFPPVQ
QLQDSSTLES		QALSTSFHQQ		SLLQAPSSDG		MNVTTRLIQE		SSQEELDLQA
QGSQFLEDNE		DQSRRSYRCD		YCNKGFKKSS		HLKQHVRSHT		GEKPYKCKLC
GRGFVSSGVL		KSHEKTHTGV		KAFSCSVCNA		SFTTNGSLTR		HMATHMSMKP
YKCPFCEEGF		RTTVHCKKHM		KRHQTVPSAV		SATGETEGGD		ICMEEEEEHS
DRNASRKSRP		EVITFTEEET		AQLAKIRPQE		SATVSEKVLV		QSAAEKDRIS
ELRDKQAELQ		DEPKHANCCT		YCPKSFKKPS		DLVRHVRIHT		GEKPYKCDEC
GKSFTVKSTL		DCHVKTHTGQ		KLFSCHVCSN		AFSTKGSLKV		HMRLHTGAKP
FKCPHCELRF		RTSGRRKTHM		QFHYKPDPKK		ARKPMTRSSS		EGLQPVNLLN
SSSTDPNVFI		MNNSVLTGQF		DQNLLQPGLV		GQAILPASVS		AGGDLTVSLT
DGSLATLEGI		QLQLAANLVG		PNVQISGIDA		ASINNITLQI		DPSILQQTLQ
QGNLLAQQLT		GEPGLAPQNS		SLQTSDSTVP		ASVVIQPISG		LSLQPTVTSA
NLTIGPLSEQ		DSVLTTNSSG		TQDLTQVMTS		QGLVSPSGGP		HEITLTINNS
SLSQVLAQAA		GPTATSSSGS		PQEITLTISE		LNTTSGSLPS		TTPMSPSAIS
TQNLVMSSSG		VGGDASVTLT		LADTQGMLSG		GLDTVTLNIT		SQGQQFPALL
TDPSLSGQGG		AGSPQVILVS		HTPQSASAAC		EEIAYQVAGV		SGNLAPGNQP
EKEGRAHQCL		ECDRAFSSAA		VLMHHSKEVH		GRERIHGCPV		CRKAFKRATH
LKEHMQTHQA		GPSLSSQKPR		VFKCDTCEKA		FAKPSQLERH		SRIHTGERPF
HCTLCEKAFN		QKSALQVHMK		KHTGERPYKC		AYCVMGFTQK		SNMKLHMKRA
HSYAGALQES		AGHPEQDGEE		LSRTLHLEEV		VQEAAGEWQA		LTHVF

Reference

1. GRCh38: Ensembl release 89: ENSG00000130856 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041258 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 236".
6. "UniProt, Q9UL36". Pristupljeno 12. 9. 2017.

Dopunska literatura

• Holmes DI, Abdel Wahab N, Mason RM (septembar 1997). "Identification of glucose-regulated genes in human mesangial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 238 (1): 179–84. doi:10.1006/bbrc.1997.7265. PMID 9299475.
• Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y (august 2013). "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan". Cancer Science. 104 (8): 1074–82. doi:10.1111/cas.12186. PMC 7657179. PMID 23648065. S2CID 5954226.
• Holmes DI, Wahab NA, Mason RM (august 1999). "Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23". Genomics. 60 (1): 105–9. doi:10.1006/geno.1999.5897. PMID 10458916.
• McDonough CW, Bostrom MA, Lu L, Hicks PJ, Langefeld CD, Divers J, Mychaleckyj JC, Freedman BI, Bowden DW (decembar 2009). "Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping". Human Genetics. 126 (6): 805–17. doi:10.1007/s00439-009-0732-8. PMC 2937163. PMID 19690890.
• Halama N, Yard-Breedijk A, Vardarli I, Akkoyun I, Yard B, Janssen B, van der Woude FJ (septembar 2003). "The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy". Genomics. 82 (3): 406–11. doi:10.1016/s0888-7543(03)00120-4. PMID 12906866.