UDP-glukuronskokiselinska dekarbokslaza 1 jest enzim koji je kod ljudi kodiran genom UXS1 sa hromosoma 2.[5][6]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 420 aminokiselina, a molekulska težina 47.577 Da.[7]
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MVSKALLRLV | | SAVNRRRMKL | | LLGIALLAYV | | ASVWGNFVNM | | RSIQENGELK |
IESKIEEMVE | | PLREKIRDLE | | KSFTQKYPPV | | KFLSEKDRKR | | ILITGGAGFV |
GSHLTDKLMM | | DGHEVTVVDN | | FFTGRKRNVE | | HWIGHENFEL | | INHDVVEPLY |
IEVDQIYHLA | | SPASPPNYMY | | NPIKTLKTNT | | IGTLNMLGLA | | KRVGARLLLA |
STSEVYGDPE | | VHPQSEDYWG | | HVNPIGPRAC | | YDEGKRVAET | | MCYAYMKQEG |
VEVRVARIFN | | TFGPRMHMND | | GRVVSNFILQ | | ALQGEPLTVY | | GSGSQTRAFQ |
YVSDLVNGLV | | ALMNSNVSSP | | VNLGNPEEHT | | ILEFAQLIKN | | LVGSGSEIQF |
LSEAQDDPQK | | RKPDIKKAKL | | MLGWEPVVPL | | EEGLNKAIHY | | FRKELEYQAN |
NQYIPKPKPA | | RIKKGRTRHS |
UDP-glukuronat dekarboksilaza (UGD; EC 4.1.1.35) katalizira stvaranje UDP-ksiloze iz UDP-glukuronata. UDP-ksiloza se zatim koristi za iniciranje biosinteze glikozaminoglikana na jezgri proteinskih proteoglikanaa (prema OMIM-u)[6]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Moriarity JL, Hurt KJ, Resnick AC, et al. (2002). "UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization". J. Biol. Chem. 277 (19): 16968–75. doi:10.1074/jbc.M109316200. PMID 11877387.
- Hwang HY, Horvitz HR (2002). "The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14218–23. Bibcode:2002PNAS...9914218H. doi:10.1073/pnas.172522199. PMC 137864. PMID 12391314.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.