Navodna kinon-oksidoreduktaza jest enzim koji je kod ljudi kodiran genom TP53I3 sa hromosoma 2.[3][4][5][6]
Kratke činjenice Dostupne strukture, PDB ...
Zatvori
Dužina polipeptidnog lanca je 332 aminokiseline, a molekulska težina 35.536 Da.[7]
10 | | 20 | | 30 | | 40 | | 50 |
MLAVHFDKPG | | GPENLYVKEV | | AKPSPGEGEV | | LLKVAASALN | | RADLMQRQGQ |
YDPPPGASNI | | LGLEASGHVA | | ELGPGCQGHW | | KIGDTAMALL | | PGGGQAQYVT |
VPEGLLMPIP | | EGLTLTQAAA | | IPEAWLTAFQ | | LLHLVGNVQA | | GDYVLIHAGL |
SGVGTAAIQL | | TRMAGAIPLV | | TAGSQKKLQM | | AEKLGAAAGF | | NYKKEDFSEA |
TLKFTKGAGV | | NLILDCIGGS | | YWEKNVNCLA | | LDGRWVLYGL | | MGGGDINGPL |
FSKLLFKRGS | | LITSLLRSRD | | NKYKQMLVNA | | FTEQILPHFS | | TEGPQRLLPV |
LDRIYPVTEI | | QEAHKYMEAN | | KNIGKIVLEL | | PQ |
Protein koji je kodiran ovim genom sličan je oksidoreduktazama, enzimima uključenim u ćelijske odgovore na oksidativni stres i zračenje. Ovaj gen inducira tumorski supresor p53 i smatra se da je uključen u p53 posredovanu ćelijsku smrt. Sadrži konsenzusno vezujuće mjesto p53 u svom promotorskom području i nizvodnu pentanukleotidnu mikrosatelitsku sekvencu. Pokazalo se da P53 transkripcijski aktivira ovaj gen interakcijom sa nizvodnom pentanukleotidnom mikrosatelitskom sekvencom. Mikrosatelit je polimorfan, sa različitim brojem pentanukleotidnih ponavljanja u direktnoj korelaciji sa stepenom aktivacije transkripcije putem p53. Sugerirano je da mikrosatelitski polimorfizam može biti povezan s različitom osjetljivošću na kancer. Za ovaj gen su pronađene najmanje dvije varijante transkripta koje kodiraju isti protein.[6]
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- Rohaly G, Chemnitz J, Dehde S, et al. (2005). "A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint". Cell. 122 (1): 21–32. doi:10.1016/j.cell.2005.04.032. PMID 16009130. S2CID 2350226.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.