TNFSF18

Član 18 natporodice ligandnih tumorskog faktora nekroze jest protein koji je kod ljudi kodiran genom TNFSF18 sa hromosoma 1.^[5][6][7]

TNFSF18
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2Q1M, 2R30, 2R32, 3B93, 3B94
Identifikatori
Aliasi	TNFSF18
Vanjski ID-jevi	OMIM: 603898 MGI: 2673064 HomoloGene: 3732 GeneCards: TNFSF18
Lokacija gena (čovjek) Hrom. Hromosom 1 (čovjek)[1] Bend 1q25.1 Početak 173,039,202 bp[1] Kraj 173,050,941 bp[1]
Lokacija gena (miš) Hrom. Hromosom 1 (miš)[2] Bend 1 H2.1|1 69.75 cM Početak 161,322,224 bp[2] Kraj 161,332,859 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • cytokine activity • signaling receptor binding • GO:0001948, GO:0016582 vezivanje za proteine • tumor necrosis factor receptor superfamily binding • vezivanje identičnih proteina Ćelijska komponenta • integral component of membrane • membrana • ćelijska membrana • Vanćelijsko • cell surface Biološki proces • adaptive immune response • positive regulation of leukocyte migration • immune system process • cell-cell signaling • negative regulation of apoptotic process • GO:0072468 Transdukcija signala • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • T cell proliferation involved in immune response • tumor necrosis factor-mediated signaling pathway • regulation of T cell proliferation • positive regulation of cell adhesion • positive regulation of NF-kappaB transcription factor activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8995	240873
Ensembl	ENSG00000120337	ENSMUSG00000066755
UniProt	Q9UNG2	Q7TS55
RefSeq (mRNK)	NM_005092	NM_183391
RefSeq (bjelančevina)	NP_005083	NP_899247
Lokacija (UCSC)	Chr 1: 173.04 – 173.05 Mb	Chr 1: 161.32 – 161.33 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 199 aminokiselina, a molekulska težina 22.724 Da.^[8]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTLHPSPITC		EFLFSTALIS		PKMCLSHLEN		MPLSHSRTQG		AQRSSWKLWL
FCSIVMLLFL		CSFSWLIFIF		LQLETAKEPC		MAKFGPLPSK		WQMASSEPPC
VNKVSDWKLE		ILQNGLYLIY		GQVAPNANYN		DVAPFEVRLY		KNKDMIQTLT
NKSKIQNVGG		TYELHVGDTI		DLIFNSEHQV		LKNNTYWGII		LLANPQFIS

Funkcija

Protein kodiran ovim genom je citokin koji pripada porodici liganda faktora tumorske nekroze (TNF). Ovaj citokin je ligand za receptor TNFRSF18/AITR/GITR. Pokazalo se da modulira preživljavanje T-limfocit a u perifernim tkivima. Ovaj citokin je također otkriven u endotelnim ćelijama i smatra se da je važan za interakciju između njih T-limfocita.^[7]

Reference

1. GRCh38: Ensembl release 89: ENSG00000120337 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066755 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kwon B, Yu KY, Ni J, Yu GL, Jang IK, Kim YJ, Xing L, Liu D, Wang SX, Kwon BS (Mar 1999). "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand". J Biol Chem. 274 (10): 6056–61. doi:10.1074/jbc.274.10.6056. PMID 10037686.
6. Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A (Apr 1999). "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR". Curr Biol. 9 (4): 215–8. doi:10.1016/S0960-9822(99)80093-1. PMID 10074428. S2CID 110695.
7. "Entrez Gene: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18".
8. "UniProt, Q9UNG2" (jezik: engleski). Pristupljeno 19. 12. 2021.

Dopunska literatura

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Yu KY, Kim HS, Song SY, et al. (2003). "Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells". Biochem. Biophys. Res. Commun. 310 (2): 433–8. doi:10.1016/j.bbrc.2003.09.024. PMID 14521928.
• Kim BJ, Li Z, Fariss RN, et al. (2004). "Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors". Invest. Ophthalmol. Vis. Sci. 45 (9): 3170–6. doi:10.1167/iovs.03-0919. PMID 15326137.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nardelli B, Zaritskaya L, McAuliffe W, et al. (2006). "Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells". Endocrinology. 147 (1): 70–8. doi:10.1210/en.2005-0518. PMID 16179414.
• Hanabuchi S, Watanabe N, Wang YH, et al. (2006). "Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL)". Blood. 107 (9): 3617–23. doi:10.1182/blood-2005-08-3419. PMID 16397134.
• Mahesh SP, Li Z, Liu B, et al. (2006). "Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines". Eur. J. Immunol. 36 (8): 2128–38. doi:10.1002/eji.200635893. PMID 16874737.
• Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, et al. (2006). "Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis". Acta Derm. Venereol. 86 (5): 393–8. doi:10.2340/00015555-0118. PMID 16955181.
• Baltz KM, Krusch M, Bringmann A, et al. (2007). "Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions". FASEB J. 21 (10): 2442–54. doi:10.1096/fj.06-7724com. PMID 17360848. S2CID 6617086.
• Tuyaerts S, Van Meirvenne S, Bonehill A, et al. (2007). "Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells". J. Leukoc. Biol. 82 (1): 93–105. doi:10.1189/jlb.0906568. PMID 17449724. S2CID 19288807.
• Bae EM, Kim WJ, Suk K, et al. (2007). "Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages". Mol. Immunol. 45 (2): 523–33. doi:10.1016/j.molimm.2007.05.013. PMID 17602748.
• Kim YS, Jung HW, Choi J, et al. (2007). "Expression of AITR and AITR ligand in breast cancer patients". Oncol. Rep. 18 (5): 1189–94. doi:10.3892/or.18.5.1189. PMID 17914571.

Vanjski linkovi